A major decrease in viral acute gastroenteritis in hospitalized Finnish children as rotavirus returns as the most detected pathogen

Autor: Oskari Pitkänen, Jukka Markkula, Maria Hemming-Harlo

Publikováno v: International Journal of Infectious Diseases, Vol 114, Iss , Pp 273-278 (2022)

Introduction: This study was performed to assess the prevalence and circulating genotypes of rotavirus, norovirus, and sapovirus in children. The results were compared to those of previous surveillance studies covering the years 2006–2008, 2009–2

Externí odkaz: https://doaj.org/article/7ce7f7f4dd234defb65ca1581486f30d

Lot-to-lot consistency, safety, tolerability, and immunogenicity of V114, a 15-valent pneumococcal conjugate vaccine, in healthy adults aged ≥50 years: A randomized phase 3 trial (PNEU-TRUE)

Autor: Jakub K. Simon, Nina Breinholt Staerke, Maria Hemming-Harlo, Stacey Layle, Ron Dagan, Tulin Shekar, Alison Pedley, Patricia Jumes, Gretchen Tamms, Tina Sterling, Luwy Musey, Ulrike K. Buchwald

Publikováno v: Simon, J K, Staerke, N B, Hemming-Harlo, M, Layle, S, Dagan, R, Shekar, T, Pedley, A, Jumes, P, Tamms, G, Sterling, T, Musey, L, Buchwald, U K & for the V114-020 PNEU-TRUE study group 2022, ' Lot-to-lot consistency, safety, tolerability, and immunogenicity of V114, a 15-valent pneumococcal conjugate vaccine, in healthy adults aged ≥50 years : A randomized phase 3 trial (PNEU-TRUE) ', Vaccine, vol. 40, no. 9, pp. 1342-1351 . https://doi.org/10.1016/j.vaccine.2021.12.067

Background: Older adults are at risk of pneumococcal disease and associated morbidity and mortality. This phase 3 study (V114-020) assessed lot-to-lot consistency across safety and immunogenicity outcomes for V114, a 15-valent pneumococcal conjugate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9bb2511ba3755a3cf65851234279086
https://doi.org/10.1016/j.vaccine.2021.12.067

Shedding of oral pentavalent bovine-human reassortant rotavirus vaccine indicates high uptake rate of vaccine and prominence of G-type G1

Autor: Jukka Markkula, Timo Vesikari, Maria Hemming-Harlo

Publikováno v: Vaccine. 38:1378-1383

Background Live oral pentavalent bovine-human reassortant rotavirus (RV) vaccine, RotaTeq®, contains bovine rotaviruses reassorted with human G-types G1, G2, G3 and G4, and P-type P[8]. Shedding of RotaTeq® vaccine, as studied by RT-PCR, has been s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cbc7d7288a60a13b4fe68976d0a833f
https://doi.org/10.1016/j.vaccine.2019.12.007

Rotavirus Vaccination Does Not Increase Type 1 Diabetes and May Decrease Celiac Disease in Children and Adolescents

Autor: Maria Hemming-Harlo, Marja-Leena Lähdeaho, Markku Mäki, Timo Vesikari

Publikováno v: Pediatric Infectious Disease Journal. 38:539-541

Rotavirus (RV) infection has been proposed to trigger type 1 diabetes mellitus (DM1) and celiac disease (CD) by molecular mimicry in genetically susceptible children. If so, a live attenuated oral RV vaccine could also trigger these autoimmune diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1477ab0ac701cb2f92a9d1821e84d1
https://doi.org/10.1097/inf.0000000000002281

Norovirus detection from sera of young children with acute norovirus gastroenteritis

Autor: Leena Huhti, Timo Vesikari, Maria Hemming-Harlo

Publikováno v: Journal of Clinical Virology. 79:6-9

Background Antigenemia and viremia are common in rotavirus infection but only few studies have shown norovirus (NoV) RNA in the blood circulation. Objectives To detect NoV RNA from serum of NoV-infected children and study if NoV RNAemia correlates wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb4c86ff1047eb738b58fc4fbb6c93a
https://doi.org/10.1016/j.jcv.2016.03.021