Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Maria H.J. van Osch"'
Autor:
Geert J.P.L. Kops, Nazneen Rahman, Sandra Hanks, Frank L. Bos, Maria H.J. van Osch, Saskia J.E. Suijkerbuijk
Supplementary Figures 1-5, Table 1 from Molecular Causes for BUBR1 Dysfunction in the Human Cancer Predisposition Syndrome Mosaic Variegated Aneuploidy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e897a1e0c8d5a6c62cfee238d2b85e6
https://doi.org/10.1158/0008-5472.22382025.v1
https://doi.org/10.1158/0008-5472.22382025.v1
Autor:
Geert J.P.L. Kops, Nazneen Rahman, Sandra Hanks, Frank L. Bos, Maria H.J. van Osch, Saskia J.E. Suijkerbuijk
Genetic mutations in the mitotic regulatory kinase BUBR1 are associated with the cancer-susceptible disorder mosaic variegated aneuploidy (MVA). In patients with biallelic mutations, a missense mutation pairs with a truncating mutation. Here, we show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c481b3ee1a6293a4df9fe0fd45e4fbd7
https://doi.org/10.1158/0008-5472.c.6500073.v1
https://doi.org/10.1158/0008-5472.c.6500073.v1
Autor:
Eelco C. Tromer, Geert J. P. L. Kops, Anastassis Perrakis, Dene R. Littler, Maria H.J. van Osch, Valeria De Marco, Mathijs Vleugel, Wilco Nijenhuis, Berend Snel, Eleonore von Castelmur
Publikováno v:
The Journal of Cell Biology
The kinetochore localization of MPS1 is necessary for mitotic checkpoint activity and requires the microtubule-binding domain of HEC1 and the Aurora B–dependent regulation of the TPR domain.
The mitotic checkpoint ensures correct chromosome se
The mitotic checkpoint ensures correct chromosome se
Autor:
Saskia J.E. Suijkerbuijk, Sandra Hanks, Frank L. Bos, Maria H.J. van Osch, Nazneen Rahman, Geert J. P. L. Kops
Publikováno v:
Cancer Research. 70:4891-4900
Genetic mutations in the mitotic regulatory kinase BUBR1 are associated with the cancer-susceptible disorder mosaic variegated aneuploidy (MVA). In patients with biallelic mutations, a missense mutation pairs with a truncating mutation. Here, we show
Autor:
Said Movahedi Naini, Maria H.J. van Osch, Sander van den Heuvel, Jagesh V. Shah, Geert J. P. L. Kops, Dirk M. Hentschel, Monique van der Voet, John R. Yates, Michael S. Manak, Ian McLeod, Andrea G. Brear
Publikováno v:
Journal of Cell Science. 123:1623-1633
Error-free chromosome segregation depends on timely activation of the multi-subunit E3 ubiquitin ligase APC/C. Activation of the APC/C initiates chromosome segregation and mitotic exit by targeting critical cell-cycle regulators for destruction. The
Autor:
René H. Medema, Carin W.A. Cruijsen, Niels J. F. van den Broek, Susanne M.A. Lens, Maria H.J. van Osch, Geert J. P. L. Kops, Nannette Jelluma, Arjan B. Brenkman
Publikováno v:
Cell. 132:233-246
Summary Maintenance of chromosomal stability relies on coordination between various processes that are critical for proper chromosome segregation in mitosis. Here we show that monopolar spindle 1 (Mps1) kinase, which is essential for the mitotic chec