Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Maria H. Poczatek"'
Autor:
Joanne E. Murphy-Ullrich, Katherine R. Tuttle, Sheryl K. Cooney, Robert F. Chouinard, Maria H. Poczatek, Stephanie D. Flynn, Rick L. Meek
Publikováno v:
American Journal of Physiology-Renal Physiology. 285:F79-F86
High-protein diets exacerbate glomerular hyperfiltration and the progression of diabetic nephropathy. The purpose of this study was to determine whether amino acids also produce nonhemodynamic injury in the glomerulus. When rat mesangial cells were c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6596a1f74ef30f9476cf333515806ee
https://doi.org/10.1152/ajprenal.00419.2002
https://doi.org/10.1152/ajprenal.00419.2002
Autor:
Maria H. Poczatek, Victor M. Darley-Usmar, Shuxia Wang, Joanne E. Murphy-Ullrich, Sruti Shiva
Publikováno v:
Journal of Biological Chemistry. 277:9880-9888
Excessive transforming growth factor-beta (TGF-beta) activity in hyperglycemia contributes to the development of diabetic nephropathy. Glucose stimulation of TGF-beta activity and matrix synthesis are dependent on autocrine thrombospondin 1 (TSP1) to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4ce8b55f5d200239dd76b11a3477e92
https://doi.org/10.1074/jbc.m108360200
https://doi.org/10.1074/jbc.m108360200
Publikováno v:
The American Journal of Pathology. 157:1353-1363
Glucose is a key factor in the development of diabetic complications, including diabetic nephropathy. The development of diabetic glomerulosclerosis is dependent on the fibrogenic growth factor, transforming growth factor-beta (TGF-beta). Previously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f67c49909b1e557d38784b75b59ea4f
https://doi.org/10.1016/s0002-9440(10)64649-4
https://doi.org/10.1016/s0002-9440(10)64649-4
Autor:
Maria H. Poczatek, Stacey Schultz-Cherry, Joanne E. Murphy-Ullrich, Solange M. F. Ribeiro, Matteo Villain
Publikováno v:
Journal of Biological Chemistry. 274:13586-13593
One of the primary points of regulation of transforming growth factor-beta (TGF-beta) activity is control of its conversion from the latent precursor to the biologically active form. We have identified thrombospondin-1 as a major physiological regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e135a5144f5d6ec5923622b80d0a12d
https://doi.org/10.1074/jbc.274.19.13586
https://doi.org/10.1074/jbc.274.19.13586
Publikováno v:
Biochemical and biophysical research communications. 339(2)
Renal and cardiac fibrosis leading to organ failure are complications of both diabetes and hypertension. These disease processes, when combined, exacerbate development of fibrotic complications. Control of latent transforming growth factor (TGF)-beta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7390066d430de617ba0111b58e97e508
https://pubmed.ncbi.nlm.nih.gov/16310163
https://pubmed.ncbi.nlm.nih.gov/16310163
Publikováno v:
Cytokinegrowth factor reviews. 11(1-2)
Regulation of the activation of latent TGF-beta is essential for health as too much or too little TGF-beta activity can have serious, deleterious consequences. The processes that control conversion of the precursor to the biologically active form of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94ce0d0df27ecdd4d8e105f01d81a52a
https://pubmed.ncbi.nlm.nih.gov/10708953
https://pubmed.ncbi.nlm.nih.gov/10708953