Evaluation of the Influence of Process Parameters on the Properties of Resveratrol-Loaded NLC Using 22 Full Factorial Design

Autor: Andréa A. M. Shimojo, Ana Rita V. Fernandes, Nuno R. E. Ferreira, Elena Sanchez-Lopez, Maria H. A. Santana, Eliana B. Souto

Publikováno v: Antioxidants, Vol 8, Iss 8, p 272 (2019)

Resveratrol (RSV) is a natural antioxidant commonly found in grapes, berries, and nuts that has shown promising results in the treatment of a variety of degenerative and age-related diseases. Despite the proven beneficial results on reduction of reac

Externí odkaz: https://doaj.org/article/70ac9f73b60c4620bef27c0d3e8e94b7

Mitotane liposomes for potential treatment of adrenal cortical carcinoma

Autor: Patricia, Zancanella, Daniele M L, Oliveira, Bonald H, de Oliveira, Thiago D, Woiski, Cesar C, Pinto, Maria H A, Santana, Eliana B, Souto, Patrícia, Severino

Publikováno v: Pharmaceutical development and technology. 25(8)

The adrenal cortical carcinoma (ACC) treatment, for which mitotane (o,p'-DDD) is the drug of choice, still remains a challenge both because of the well-known solubility problems of the drug, and its serious side effects. Mitotane is currently adminis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::71caf347b6d0bf55c51809a1c9625aef
https://pubmed.ncbi.nlm.nih.gov/32343624

Synthesis of the diacetylenic phospholipids 1,2-(10',12'-heptadecadiynoyl)-sn-glycero-3-phophatidylcholine and 1,2-(4',6'-tricosadiynoyl)-sn-glycero-3-phophatidylcholine

Autor: Maria H. C. Santana, Carlos Roque D. Correia, Paulo T. Hennies

Publikováno v: Journal of the Brazilian Chemical Society, Volume: 12, Issue: 1, Pages: 64-72, Published: 2001
Journal of the Brazilian Chemical Society v.12 n.1 2001
Journal of the Brazilian Chemical Society
Sociedade Brasileira de Química (SBQ)
instacron:SBQ
Journal of the Brazilian Chemical Society, Vol 12, Iss 1, Pp 64-72 (2001)

Diacetylenic phosphatidylcholines are synthetic compounds analogous to natural phospholipids. These molecules can be hydrated to form bilayered aggregates known as liposomes in a manner similar to natural phosphatidylcholines. A particular feature of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7883ab0882b766996931a1c66033a605
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532001000100009&lng=en&tlng=en

Antimycobacterial and cytotoxicity activities of free and liposome-encapsulated 3-(4'-bromo[1,1'-biphenyl-4-yl)-3-(4-bromo-phenyl)-N,N-dimethyl-2-propen-1-amine

Autor: Ana O. de Souza, Célio L. Silva, Nelson Durán, Maria H. Andrade-Santana

Publikováno v: Química Nova, Vol 33, Iss 4, Pp 871-874 (2010)

The antimycobacterial activity of 3-(4'-bromo[1,1'-biphenyl-4-yl)-3-(4-bromo-phenyl)-N,N-dimethyl-2-propen-1-amine (BBAP), free or incorporated in preformed liposomes, on extracellular M. tuberculosis H37Rv was 8 and 25 μM (MIC), respectively. Extra

Externí odkaz: https://doaj.org/article/cc3ab248bb964828907ed52e62d3c748