Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Maria Grazia Farrace"'
Autor:
Luca Occhigrossi, Federica Rossin, Valeria Rachela Villella, Speranza Esposito, Carlo Abbate, Manuela D’Eletto, Maria Grazia Farrace, Antonella Tosco, Roberta Nardacci, Gian Maria Fimia, Valeria Raia, Mauro Piacentini
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Cystic fibrosis (CF) is a rare autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The most common mutation is F508del-CFTR (ΔF) which leads the encoded ion channel towards misfoldi
Externí odkaz:
https://doaj.org/article/7f5505c5364c46dbb11974be90ac7257
Autor:
Federica Rossin, Roberto Costa, Matteo Bordi, Manuela D’Eletto, Luca Occhigrossi, Maria Grazia Farrace, Nickolai Barlev, Fabiola Ciccosanti, Silvia Muccioli, Leonardo Chieregato, Ildiko Szabo, Gian Maria Fimia, Mauro Piacentini, Luigi Leanza
Publikováno v:
Cell Death and Disease, Vol 12, Iss 3, Pp 1-13 (2021)
Abstract TG2 is a multifunctional enzyme involved in several cellular processes and has emerging as a potential regulator of gene expression. In this regard, we have recently shown that TG2 is able to activate HSF1, the master transcriptional regulat
Externí odkaz:
https://doaj.org/article/266616b6e9a246dba598ea758ad22616
Autor:
Manuela D’Eletto, Federica Rossin, Luca Occhigrossi, Maria Grazia Farrace, Danilo Faccenda, Radha Desai, Saverio Marchi, Giulia Refolo, Laura Falasca, Manuela Antonioli, Fabiola Ciccosanti, Gian Maria Fimia, Paolo Pinton, Michelangelo Campanella, Mauro Piacentini
Publikováno v:
Cell Reports, Vol 25, Iss 13, Pp 3573-3581.e4 (2018)
Summary: Transglutaminase type 2 (TG2) is a multifunctional enzyme that plays a key role in mitochondria homeostasis under stressful cellular conditions. TG2 interactome analysis reveals an enzyme interaction with GRP75 (glucose-regulated protein 75)
Externí odkaz:
https://doaj.org/article/a83291863d9942ff9278c205e58a4ea1
Autor:
Alessandra Sacchi, Roberta Nardacci, Delia Goletti, Nick Barlev, Evgeni Smirnov, Ivana Palucci, Federica Rossin, Fabiola Ciccosanti, Gian Maria Fimia, Laura Falasca, Mauro Piacentini, Linda Petrone, Giovanni Delogu, Franca Del Nonno, Chiara Agrati, Maria Grazia Farrace, Manuela D’Eletto, Luca Occhigrossi
We have recently shown that type 2 transglutaminase (TG2) plays a key role in the host’s inflammatory response during bacterial infections. In this study, we investigated whether the enzyme is involved in the regulation of the STING pathway, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e5da809fe1b98780773be911738df6
http://hdl.handle.net/11573/1572489
http://hdl.handle.net/11573/1572489
Autor:
Danilo Faccenda, Luca Occhigrossi, Saverio Marchi, Paolo Pinton, Laura Falasca, Fabiola Ciccosanti, Maria Grazia Farrace, Manuela D’Eletto, Federica Rossin, Gian Maria Fimia, Radha Desai, Giulia Refolo, Manuela Antonioli, Mauro Piacentini, Michelangelo Campanella
Publikováno v:
Cell Reports, Vol 25, Iss 13, Pp 3573-3581.e4 (2018)
Cell Reports
Cell Reports
Summary: Transglutaminase type 2 (TG2) is a multifunctional enzyme that plays a key role in mitochondria homeostasis under stressful cellular conditions. TG2 interactome analysis reveals an enzyme interaction with GRP75 (glucose-regulated protein 75)
The maintenance of protein homeostasis (proteostasis) is a fundamental aspect of cell physiology that is essential for the survival of organisms under a variety of environmental and/or intracellular stress conditions. Acute and/or persistent stress e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abe6625832018d77204de375aaf0108f
http://hdl.handle.net/2108/207043
http://hdl.handle.net/2108/207043
Autor:
Valeria Rachela Villella, Mauro Piacentini, Vittoria Pagliarini, Maria Grazia Farrace, N. A. Barlev, Gian Maria Fimia, Romina Monzani, Giorgio Cozza, Manuela D’Eletto, Luigi Maiuri, Valeria Raia, Eleonora Ferrari, Speranza Esposito, Claudio Sette, Laura Falasca, Luca Occhigrossi, Guido Kroemer, Federica Rossin
Heat-shock factor 1 (HSF1) is the master transcription factor that regulates the response to proteotoxic stress by controlling the transcription of many stress-responsive genes including the heat-shock proteins. Here, we show a novel molecular mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f73611d07f72c2b0f6a8c8b7a26f16d
http://hdl.handle.net/11573/1411308
http://hdl.handle.net/11573/1411308
Autor:
Federica Rossin, Laura Falasca, Pier G. Mastroberardino, Sara Sepe, Maria Grazia Farrace, Stefania Cocco, Manuela D’Eletto, Mauro Piacentini, Michelangelo Campanella, Gian Maria Fimia
Publikováno v:
Cell Death & Differentiation, 22(3), 408-418. Nature Publishing Group
Macroautophagy selectively degrades dysfunctional mitochondria by a process known as mitophagy. Here we demonstrate the involvement of transglutaminase 2 (TG2) in the turnover and degradation of damaged mitochondria. In TG2-ablated cells we observed
The human transglutaminases (TGases) are a widely distributed and peculiar group of enzymes that catalyze the posttranslational modification of proteins by the formation of isopeptide bonds. Tissue or type 2 transglutaminase (TG2) represents the most
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::717e0c37ece396443b25bc791aa0a14a
https://doi.org/10.1016/bs.mie.2016.10.011
https://doi.org/10.1016/bs.mie.2016.10.011
Autor:
Laura Diaz Hidalgo, Laura Falasca, Michelangelo Campanella, Sara Altuntas, Lucia Piredda, Maria Grazia Farrace, Mauro Piacentini, Pier G. Mastroberardino, Federica Rossin, Manuela D’Eletto, Stefania Cocco
Publikováno v:
Mitochondrion, 19, 97-104. Elsevier
Mitochondria produce the bulk of cellular energy and work as decisional "hubs" for cellular responses by integrating different input signals. The determinant in the physiopathology of mammals, they attract major attention, nowadays, for their contrib