Zobrazeno 1 - 10
of 292
pro vyhledávání: '"Maria Grazia, Spillantini"'
Autor:
Catherine K. Xu, Georg Meisl, Ewa A. Andrzejewska, Georg Krainer, Alexander J. Dear, Marta Castellana-Cruz, Soma Turi, Irina A. Edu, Giorgio Vivacqua, Raphaël P. B. Jacquat, William E. Arter, Maria Grazia Spillantini, Michele Vendruscolo, Sara Linse, Tuomas P. J. Knowles
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Oligomeric species arising during the aggregation of α-synuclein are implicated as a major source of toxicity in Parkinson’s disease, and thus a major potential drug target. However, both their mechanism of formation and role in aggregati
Externí odkaz:
https://doaj.org/article/a4d1104eb0184ade8af0b5e5b4fb8983
Autor:
Mehtap Bacioglu, Manuel Schweighauser, Derrick Gray, Sofia Lövestam, Taxiarchis Katsinelos, Annelies Quaegebeur, John van Swieten, Zane Jaunmuktane, Stephen W. Davies, Sjors H. W. Scheres, Michel Goedert, Bernardino Ghetti, Maria Grazia Spillantini
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-14 (2024)
Abstract Filaments made of residues 120-254 of transmembrane protein 106B (TMEM106B) form in an age-dependent manner and can be extracted from the brains of neurologically normal individuals and those of subjects with a variety of neurodegenerative d
Externí odkaz:
https://doaj.org/article/db92f0d916014e6583ce491ec51339dd
Autor:
Mehtap Bacioglu, Derrick Gray, Sofia Lövestam, Taxiarchis Katsinelos, Annelies Quaegebeur, John van Swieten, Zane Jaunmuktane, Stephen W. Davies, Sjors H. W. Scheres, Michel Goedert, Bernardino Ghetti, Maria Grazia Spillantini
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/f79972c74ca54708918298cfe5ab3590
Autor:
Jason C. Sang, Eric Hidari, Georg Meisl, Rohan T. Ranasinghe, Maria Grazia Spillantini, David Klenerman
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Jason Sang et al. use super-resolution microscopy to monitor α-synuclein aggregation and uptake in SH-SY5Y neuroblastoma cells. Their results suggest that cells secrete nanoscopic aggregates in response to disruption of protein homeostasis by these
Externí odkaz:
https://doaj.org/article/fb50d58e8455415e95e500de6612683f
Autor:
Johannes Levin, Nand Sing, Sue Melbourne, Amber Morgan, Carla Mariner, Maria Grazia Spillantini, Michal Wegrzynowicz, Jeffrey W. Dalley, Simon Langer, Sergey Ryazanov, Andrei Leonov, Christian Griesinger, Felix Schmidt, Daniel Weckbecker, Kai Prager, Torsten Matthias, Armin Giese
Publikováno v:
EBioMedicine, Vol 80, Iss , Pp 104021- (2022)
Summary: Background: Synucleinopathies such as Parkinson ́s disease (PD), Dementia with Lewy bodies (DLB) and Multiple System Atrophy (MSA) are characterized by deposition of misfolded and aggregated α-synuclein. Small aggregates (oligomers) of α-
Externí odkaz:
https://doaj.org/article/2aeca4c5452945a2b232932da803dc99
Autor:
Sanne Simone Kaalund, Luca Passamonti, Kieren S. J. Allinson, Alexander G. Murley, Trevor W. Robbins, Maria Grazia Spillantini, James B. Rowe
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-11 (2020)
Abstract The locus coeruleus is the major source of noradrenaline to the brain and contributes to a wide range of physiological and cognitive functions including arousal, attention, autonomic control, and adaptive behaviour. Neurodegeneration and pat
Externí odkaz:
https://doaj.org/article/2a3d4c5bf2034e748c31eb359c824d31
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/ac6604337ee0484eaf498c6541b5dcbb
Publikováno v:
Biomedicines, Vol 10, Iss 8, p 1941 (2022)
In patients affected by Parkinson’s disease (PD), the most common neurodegenerative movement disorder, the brain is characterized by the loss of dopaminergic neurons in the nigrostriatal system, leading to dyshomeostasis of the basal ganglia networ
Externí odkaz:
https://doaj.org/article/63359973fb714bab8dc5687c546c2d62
Autor:
Gaia Faustini, Francesca Longhena, Agostino Bruno, Federica Bono, Jessica Grigoletto, Luca La Via, Alessandro Barbon, Andrea Casiraghi, Valentina Straniero, Ermanno Valoti, Gabriele Costantino, Fabio Benfenati, Cristina Missale, Marina Pizzi, Maria Grazia Spillantini, Arianna Bellucci
Publikováno v:
Neurobiology of Disease, Vol 138, Iss , Pp 104789- (2020)
Loss of dopaminergic nigrostriatal neurons and fibrillary α-synuclein (α-syn) aggregation in Lewy bodies (LB) characterize Parkinson's disease (PD). We recently found that Synapsin III (Syn III), a phosphoprotein regulating dopamine (DA) release wi
Externí odkaz:
https://doaj.org/article/62b2da3107734573927f1feedb3da04f
Autor:
Matthew Mason, Mehtap Bacioglu, Giorgio Vivacqua, Maria Grazia Spillantini, Aviva M Tolkovsky
Publikováno v:
The Lancet Neurology. 22:462-464
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1b7f2e21356a5ebc1ddc31930e3dc3b
https://doi.org/10.1016/s1474-4422(23)00108-4
https://doi.org/10.1016/s1474-4422(23)00108-4