Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Maria Grazia, Ciampa"'
Autor:
Giulia Lunghi, Erika Di Biase, Emma Veronica Carsana, Alexandre Henriques, Noelle Callizot, Laura Mauri, Maria Grazia Ciampa, Luigi Mari, Nicoletta Loberto, Massimo Aureli, Sandro Sonnino, Michael Spedding, Elena Chiricozzi, Maria Fazzari
Publikováno v:
FEBS Open Bio, Vol 13, Iss 12, Pp 2324-2341 (2023)
Alterations in glycosphingolipid metabolism have been linked to the pathophysiological mechanisms of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease affecting motor neurons. Accordingly, administration of GM1, a sialic acid‐contain
Externí odkaz:
https://doaj.org/article/bc90ee2630b94cd7baec16a20f019b9f
Autor:
Maria Fazzari, Giulia Lunghi, Alexandre Henriques, Noëlle Callizot, Maria Grazia Ciampa, Laura Mauri, Simona Prioni, Emma Veronica Carsana, Nicoletta Loberto, Massimo Aureli, Luigi Mari, Sandro Sonnino, Elena Chiricozzi, Erika Di Biase
Publikováno v:
Biomedicines, Vol 11, Iss 5, p 1305 (2023)
Past evidence has shown that the exogenous administration of GM1 ganglioside slowed neuronal death in preclinical models of Parkinson’s disease, a neurodegenerative disorder characterized by the progressive loss of dopamine-producing neurons: howev
Externí odkaz:
https://doaj.org/article/8a1943fc716f42f4923a8d9f878d1326
Autor:
Diego Farinello, Monika Wozińska, Elisa Lenti, Luca Genovese, Silvia Bianchessi, Edoardo Migliori, Nicolò Sacchetti, Alessia di Lillo, Maria Teresa Sabrina Bertilaccio, Claudia de Lalla, Roberta Valsecchi, Sabrina Bascones Gleave, David Lligé, Cristina Scielzo, Laura Mauri, Maria Grazia Ciampa, Lydia Scarfò, Rosa Bernardi, Dejan Lazarevic, Blanca Gonzalez-Farre, Lucia Bongiovanni, Elias Campo, Andrea Cerutti, Maurilio Ponzoni, Linda Pattini, Federico Caligaris-Cappio, Paolo Ghia, Andrea Brendolan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
The stromal microenvironment plays a key role in the expansion of chronic lymphocytic leukemia. Here, the authors use the Eµ-TCL1 mouse model to show that leukemic B-cells induce the activation of retinoic acid synthesis in stromal cells of the lymp
Externí odkaz:
https://doaj.org/article/ae8a25dfa5e64465b221fe7111cbb8b6
Autor:
Sara Grassi, Livia Cabitta, Simona Prioni, Laura Mauri, Maria Grazia Ciampa, Noriko Yokoyama, Kazuhisa Iwabuchi, Yana Zorina, Alessandro Prinetti
Publikováno v:
Neurochemical Research. 48:1783-1797
Failure of the immune system to discriminate myelin components from foreign antigens plays a critical role in the pathophysiology of multiple sclerosis. In fact, the appearance of anti-myelin autoantibodies, targeting both proteins and glycolipids, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e451527e612af732a8ba91a8a78912
https://doi.org/10.1007/s11064-023-03859-2
https://doi.org/10.1007/s11064-023-03859-2
Autor:
Giulia Lunghi, Maria Fazzari, Maria Grazia Ciampa, Laura Mauri, Erika Di Biase, Elena Chiricozzi, Sandro Sonnino
Publikováno v:
FEBS Letters. 596:3124-3132
The interactions between gangliosides and proteins belonging to the same or different lipid domains and their influence on physiological and pathological states have been analysed in detail. A well-known factor impacting on lipid-protein interactions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12198c9ad56391755f760ab1b111ac02
https://doi.org/10.1002/1873-3468.14532
https://doi.org/10.1002/1873-3468.14532
Autor:
Elena Chiricozzi, Maria Grazia Ciampa, Giuseppina Brasile, Federica Compostella, Alessandro Prinetti, Hitoshi Nakayama, Roudy C. Ekyalongo, Kazuhisa Iwabuchi, Sandro Sonnino, Laura Mauri
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 1, Pp 129-141 (2015)
Lactosylceramide [LacCer; β-Gal-(1-4)-β-Glc-(1-1)-Cer] has been shown to contain very long fatty acids that specifically modulate neutrophil properties. The interactions between LacCer and proteins and their role in cell signaling processes were as
Externí odkaz:
https://doaj.org/article/7b139af1caf646c7b5cd72b17bda5823
Autor:
Maria Fazzari, Giulia Lunghi, Pamela Fato, Maura Samarani, Erika Di Biase, Maria Grazia Ciampa, Diego Yuri Pomè, Simona Prioni, Manuela Valsecchi, Margherita Maggioni, Sandro Sonnino, Elena Chiricozzi, Laura Mauri
Publikováno v:
Glycoconjugate Journal. 37:329-343
It has been recently reported by our group that GM1-oligosaccharide added to neuroblastoma cells or administered to mouse experimental model mimics the neurotrophic and neuroprotective properties of GM1 ganglioside. In addition to this, differently f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3577ac02658450d970b7a677587afd32
https://doi.org/10.1007/s10719-020-09919-x
https://doi.org/10.1007/s10719-020-09919-x
Autor:
Massimo Aureli, Simona Prioni, Laura Mauri, Nicoletta Loberto, Riccardo Casellato, Maria Grazia Ciampa, Vanna Chigorno, Alessandro Prinetti, Sandro Sonnino
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 4, Pp 798-808 (2010)
Human fibroblasts from normal subjects and Niemann-Pick A (NPA) disease patients were fed with two labeled metabolic precursors of sphingomyelin (SM), [3H]choline and photoactivable sphingosine, that entered into the biosynthetic pathway allowing the
Externí odkaz:
https://doaj.org/article/cdefc7d2eae5413a9b18ddcb3c7b04ab
Autor:
Elena Chiricozzi, Margherita Maggioni, Maria Fazzari, Erika Di Biase, Pamela Fato, Gianluca Verlengia, Gusheng Wu, Diego Yuri Pomè, Simona Prioni, Giulia Lunghi, Laura Mauri, Stefano Cattaneo, Robert Assini, Sandro Sonnino, Robert W. Ledeen, Nicoletta Loberto, Samar K. Alselehdar, Manuela Valsecchi, Maria Grazia Ciampa
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports
Scientific Reports
Given the recent in vitro discovery that the free soluble oligosaccharide of GM1 is the bioactive portion of GM1 for neurotrophic functions, we investigated its therapeutic potential in the B4galnt1+/− mice, a model of sporadic Parkinson’s diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb574fc4f6a4bc857fd588d7d5193af4
http://link.springer.com/article/10.1038/s41598-019-55885-2
http://link.springer.com/article/10.1038/s41598-019-55885-2
Homeostatic and pathogenic roles of GM 3 ganglioside molecular species in TLR 4 signaling in obesity
Autor:
Umeharu Ohto, Shinji Go, Mika Nagasaki, Kei-ichiro Inamori, Hiromune Ando, Marilena Letizia, Makoto Kiso, Maria Grazia Ciampa, Hideharu Ishida, Kazuya Kabayama, Toshiyuki Shimizu, Jin-ichi Inokuchi, Anna Giulia Cattaneo, Atsushi Shimoyama, Naoko Komura, Sorama Aoki, Hirotaka Kanoh, Mayu Fujii, Hiroki Shindo, Yoshihiro Natori, Taku Watanabe, Yuichi Yoshimura, Koichi Fukase, Wataru Nihei, Akemi Suzuki, Asia Zonca, Lucas Veillon, Laura Mauri, Takahiro Nitta, Yutaka Yatomi, Alessandro Prinetti, Sandro Sonnino, Kenichi Sato
Publikováno v:
The EMBO Journal
Innate immune signaling via TLR4 plays critical roles in pathogenesis of metabolic disorders, but the contribution of different lipid species to metabolic disorders and inflammatory diseases is less clear. GM3 ganglioside in human serum is composed o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a0e571142f11ea1baa7418acde7926
https://doi.org/10.15252/embj.2019101732
https://doi.org/10.15252/embj.2019101732