Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Maria Gordillo‐Marañón"'
Autor:
Amand F. Schmidt, Roshni Joshi, Maria Gordillo-Marañón, Fotios Drenos, Pimphen Charoen, Claudia Giambartolomei, Joshua C. Bis, Tom R. Gaunt, Alun D. Hughes, Deborah A. Lawlor, Andrew Wong, Jackie F. Price, Nishi Chaturvedi, Goya Wannamethee, Nora Franceschini, Mika Kivimaki, Aroon D. Hingorani, Chris Finan
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-10 (2023)
Schmidt et al. evaluate the effects of elevated circulating concentrations of cholesterol-containing lipoproteins and apolipoproteins. Effects are seen on measures of atherosclerosis, blood pressure, c-reactive protein, coronary heart disease, heart
Externí odkaz:
https://doaj.org/article/a4840a392ca142fd8b56739e6ab3255e
Autor:
Amand F. Schmidt, Nicholas B. Hunt, Maria Gordillo-Marañón, Pimphen Charoen, Fotios Drenos, Mika Kivimaki, Deborah A. Lawlor, Claudia Giambartolomei, Olia Papacosta, Nishi Chaturvedi, Joshua C. Bis, Christopher J. O’Donnell, Goya Wannamethee, Andrew Wong, Jackie F. Price, Alun D. Hughes, Tom R. Gaunt, Nora Franceschini, Dennis O. Mook-Kanamori, Magdalena Zwierzyna, Reecha Sofat, Aroon D. Hingorani, Chris Finan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Despite being studied in clinical trials, CETP inhibitors are not yet an approved treatment for coronary heart disease. Here, by analyzing results from clinical trials and drug target mendelian randomization studies, the authors demonstrate that prev
Externí odkaz:
https://doaj.org/article/60544e33b7ec4a46bdebdd316f81bb1d
Autor:
Amand F. Schmidt, Chris Finan, Maria Gordillo-Marañón, Folkert W. Asselbergs, Daniel F. Freitag, Riyaz S. Patel, Benoît Tyl, Sandesh Chopade, Rupert Faraway, Magdalena Zwierzyna, Aroon D. Hingorani
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Mendelian randomisation (MR) analysis of drug targets has potential to aid drug development. Here, the authors introduce a mathematical framework to elucidate this specific application of MR.
Externí odkaz:
https://doaj.org/article/314860a99a3044359893ed3a7d40aa29
Autor:
Junqing Xie, Albert Prats‐Uribe, Maria Gordillo‐Marañón, Victoria Y. Strauss, Dipender Gill, Daniel Prieto‐Alhambra
Publikováno v:
Journal of Thrombosis and Haemostasis, 20(12), 2887-2895. Wiley-Blackwell Publishing Ltd
BACKGROUNDCovid-19 vaccination has been associated with an increased risk of venous thromboembolism (VTE). However, it is unknown whether genetic predisposition to VTE is associated with an increased risk of thrombosis following vaccination.METHODSUs
Comparing the effects of CETP in East Asian and European ancestries: a Mendelian randomization study
Autor:
Diana Dunca, Sandesh Chopade, María Gordillo-Marañón, Aroon D. Hingorani, Karoline Kuchenbaecker, Chris Finan, Amand F. Schmidt
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract CETP inhibitors are a class of lipid-lowering drugs in development for treatment of coronary heart disease (CHD). Genetic studies in East Asian ancestry have interpreted the lack of CETP signal with low-density lipoprotein cholesterol (LDL-C
Externí odkaz:
https://doaj.org/article/23e5af9de5984d279421ac7ebb2dc74e
Autor:
María Gordillo-Marañón, Gianmario Candore, Marta López-Fauqued, Katerina-Christina Deli, Loris Piccolo, Paolo Alcini, Tom Paternoster-Howe, Irene Rager, Robin Ruepp, Menno van der Elst
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
IntroductionPeriodic Safety Update Reports (PSURs) are a key pharmacovigilance tool for the continuous evaluation of the benefit–risk balance of a medicinal product in the post-authorisation phase. The PSUR submission frequency for authorised activ
Externí odkaz:
https://doaj.org/article/0a377b317bc14f79a773c8fe17459be0
Autor:
María Gordillo-Marañón, Magdalena Zwierzyna, Pimphen Charoen, Fotios Drenos, Sandesh Chopade, Tina Shah, Jorgen Engmann, Nishi Chaturvedi, Olia Papacosta, Goya Wannamethee, Andrew Wong, Reecha Sofat, Mika Kivimaki, Jackie F. Price, Alun D. Hughes, Tom R. Gaunt, Deborah A. Lawlor, Anna Gaulton, Aroon D. Hingorani, Amand F. Schmidt, Chris Finan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Drug target Mendelian randomization (MR) uses genetic variation in or near a gene encoding a drug target to anticipate the effect of drug action on the same target. Using drug target MR, the authors prioritized 30 targets that might elicit beneficial
Externí odkaz:
https://doaj.org/article/da0636481f784c5bbf9d63d052cf0333