Maturation of human dendritic cells with Saccharomyces cerevisiae (yeast) reduces the number and function of regulatory T cells and enhances the ratio of antigen-specific effectors to regulatory T cells

Autor: James L. Gulley, Chiara Intrivici, Matteo Vergati, Jeffrey Schlom, Caroline Jochems, Ngar-Yee Huen, Kwong Y. Tsang, David Apelian, Vittore Cereda, Maria Giovanna di Bari

Publikováno v: Vaccine. 29:4992-4999

We compared the effects of yeast-treated human dendritic cells (DCs) with CD40L-matured human DCs for the induction of effector cells and the number and functionality of CD4 + CD25 + CD127 − FoxP3 + regulatory T cells (Tregs). DCs were treated with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88dca8fe17b4a3f5047703bd94ab7fd4
https://doi.org/10.1016/j.vaccine.2011.04.101

TGF-β modulates the functionality of tumor-infiltrating CD8+ T cells through effects on TCR signaling and Spred1 expression

Autor: Helen Sabzevari, Maria Giovanna di Bari, M. E. Christine Lutsiak, Shinji Takai, Sven Mostböck, Jeffrey Schlom, Benedetto Farsaci, Lalage M. Wakefield, Roshanak Tolouei Semnani

Publikováno v: Cancer Immunology, Immunotherapy. 58:1809-1818

This study demonstrates that CD8+ T cells in the tumor microenvironment display reduced functionality and hyporesponsiveness. TGF-beta contributed markedly to the tumor-infiltrating CD8+ T cells' (TILs) reduced functionality, which could be reversed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b5ffdd7b29bf53d2fcac4d9f0374fc
https://doi.org/10.1007/s00262-009-0692-9

ATM kinase activity modulates Fas sensitivity through the regulation of FLIP in lymphoid cells

Autor: Venturina Stagni, Roberto Testi, Yaniv Lerenthal, Maria Teresa Cencioni, Silvia Cursi, Maria Giovanna di Bari, Daniela Barilà, Enrico Cundari, Ivano Condò

Publikováno v: Blood (2007).
info:cnr-pdr/source/autori:Stagni V, di Bari MG, Cursi S, Condo I, Cencioni MT, Testi R, Lerenthal Y, Cundari E, Barila D./titolo:ATM kinase activity modulates Fas sensitivity through the regulation of FLIP in lymphoid cells./doi:/rivista:Blood/anno:2007/pagina_da:/pagina_a:/intervallo_pagine:/volume
Blood 111 (2008): 829–837.
info:cnr-pdr/source/autori:Stagni V, di Bari MG, Cursi S, Condò I, Cencioni MT, Testi R, Lerenthal Y, Cundari E, Barilà D./titolo:ATM kinase activity modulates Fas sensitivity through the regulation of FLIP in lymphoid cells./doi:/rivista:Blood/anno:2008/pagina_da:829/pagina_a:837/intervallo_pagine:829–837/volume:111

Ataxia telangiectasia (A-T) is a rare cancer-predisposing genetic disease, caused by the lack of functional ATM kinase, a major actor of the double strand brakes (DSB) DNA-damage response. A-T patients show a broad and diverse phenotype, which includ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::953fef1c412d904a415b2c3fdc18f980
https://pubmed.ncbi.nlm.nih.gov/17932249

Abstract 758: Cancer vaccine immunotherapy employing Saccharomyces cerevisiae (yeast) as a vector can modulate the balance between CD4+ T cells and regulatory T cells (Tregs) and enhance the specific antitumor immune response

Autor: Matteo Vergati, Jeffrey Schlom, Maria Giovanna di Bari, James L. Gulley, Vittore Cereda, Caroline Jochems, Ngar-Yee Huen, Kwong Y. Tsang, C. Intrivici, David Apelian

Publikováno v: Cancer Research. 71:758-758

Regulatory T cells (Tregs) have been broadly related to modulation of the antitumor immune response. We have previously shown that whole, heat-killed, recombinant Saccharomyces cerevisiae yeast genetically modified to express carcinoembryonic antigen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cfb194112d327904e913ab3748c711a9
https://doi.org/10.1158/1538-7445.am2011-758