Zobrazeno 1 - 10 of 23 pro vyhledávání: '"Maria Georganaki"'
1
Akademický článek
Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma
Autor: Luuk van Hooren, Alessandra Vaccaro, Mohanraj Ramachandran, Konstantinos Vazaios, Sylwia Libard, Tiarne van de Walle, Maria Georganaki, Hua Huang, Ilkka Pietilä, Joey Lau, Maria H. Ulvmar, Mikael C. I. Karlsson, Maria Zetterling, Sara M. Mangsbo, Asgeir S. Jakola, Thomas Olsson Bontell, Anja Smits, Magnus Essand, Anna Dimberg
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Agonistic CD40 antibodies (αCD40) have broad immunostimulatory properties, however their efficacy in glioma remains unclear. Here the authors show that αCD40 promotes the formation of tertiary lymphoid structures but does not improve survival and i
Externí odkaz: https://doaj.org/article/960c23767579410eb75556847b8c9b3f
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2
Akademický článek
Tumor endothelial ELTD1 as a predictive marker for treatment of renal cancer patients with sunitinib
Autor: Marjut Niinivirta, Maria Georganaki, Gunilla Enblad, Cecilia Lindskog, Anna Dimberg, Gustav J. Ullenhag
Publikováno v: BMC Cancer, Vol 20, Iss 1, Pp 1-8 (2020)
Abstract Background Patients with metastatic renal cell cancer (mRCC) are commonly treated with the tyrosine kinase inhibitor sunitinib, which blocks signalling from vascular endothelial growth factor (VEGF) - and platelet-derived growth factor-recep
Externí odkaz: https://doaj.org/article/0748aaf10fc64588805e2ac5a8b8518a
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3
Akademický článek
Tumor endothelial cell up-regulation of IDO1 is an immunosuppressive feed-back mechanism that reduces the response to CD40-stimulating immunotherapy
Autor: Maria Georganaki, Mohanraj Ramachandran, Sander Tuit, Nicolás Gonzalo Núñez, Alexandros Karampatzakis, Grammatiki Fotaki, Luuk van Hooren, Hua Huang, Roberta Lugano, Thomas Ulas, Aura Kaunisto, Eric C Holland, Peter Ellmark, Sara M Mangsbo, Joachim Schultze, Magnus Essand, Sonia Tugues, Anna Dimberg
Publikováno v: OncoImmunology, Vol 9, Iss 1 (2020)
CD40-stimulating immunotherapy can elicit potent anti-tumor responses by activating dendritic cells and enhancing T-cell priming. Tumor vessels orchestrate T-cell recruitment during immune response, but the effect of CD40-stimulating immunotherapy on
Externí odkaz: https://doaj.org/article/4a2116d5ba7b4f129b0b2715b4654949
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4
Akademický článek
Vascular Targeting to Increase the Efficiency of Immune Checkpoint Blockade in Cancer
Autor: Maria Georganaki, Luuk van Hooren, Anna Dimberg
Publikováno v: Frontiers in Immunology, Vol 9 (2018)
Boosting natural immunity against malignant cells has had a major breakthrough in clinical cancer therapy. This is mainly due to the successful development of immune checkpoint blocking antibodies, which release a break on cytolytic anti-tumor-direct
Externí odkaz: https://doaj.org/article/04f1dbeacdaf4a47b926c625c93a7b6e
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