Intestinal B-cells license metabolic T-cell activation in NASH microbiota/antigen-independently and contribute to fibrosis by IgA-FcR signalling

Autor: Elena Kotsiliti, Valentina Leone, Svenja Schuehle, Olivier Govaere, Hai Li, Monika J. Wolf, Helena Horvatic, Sandra Bierwirth, Jana Hundertmark, Donato Inverso, Laimdota Zizmare, Avital Sarusi-Portuguez, Revant Gupta, Tracy O’Connor, Anastasios D. Giannou, Ahmad Mustafa Shiri, Yehuda Schlesinger, Maria Garcia Beccaria, Charlotte Rennert, Dominik Pfister, Rupert Öllinger, Iana Gadjalova, Pierluigi Ramadori, Mohammad Rahbari, Nuh Rahbari, Marc Healy, Mirian Fernández-Vaquero, Neda Yahoo, Jakob Janzen, Indrabahadur Singh, Chaofan Fan, Xinyuan Liu, Monika Rau, Martin Feuchtenberger, Eva Schwaneck, Sebastian J. Wallace, Simon Cockell, John Wilson-Kanamori, Prakash Ramachandran, Celia Kho, Timothy J. Kendall, Anne-Laure Leblond, Selina J. Keppler, Piotr Bielecki, Katja Steiger, Maike Hofmann, Karsten Rippe, Horst Zitzlesberger, Achim Weber, Nisar Malek, Tom Lüdde, Mihael Vucur, Hellmut G. Augustin, Richard Flavell, Oren Parnas, Roland Rad, Olivier Pabst, Neil C. Henderson, Samuel Huber, Andrew Macpherson, Percy Knolle, Manfred Claasen, Andreas Geier, Christoph Trautwein, Kristian Unger, Eran Elinav, Ari Waisman, Zeinab Abdullah, Dirk Haller, Frank Tacke, Quentin M. Anstee, Mathias Heikenwalder

Publikováno v: Kotsiliti, E, Leone, V, Schuehle, S, Govaere, O, Li, H, Wolf, M J, Horvatic, H, Bierwirth, S, Hundertmark, J, Inverso, D, Zizmare, L, Sarusi-Portuguez, A, Gupta, R, O'Connor, T, Giannou, A D, Shiri, A M, Schlesinger, Y, Beccaria, M G, Rennert, C, Pfister, D, Öllinger, R, Gadjalova, I, Ramadori, P, Rahbari, M, Rahbari, N, Healy, M, Fernández-Vaquero, M, Yahoo, N, Janzen, J, Singh, I, Fan, C, Liu, X, Rau, M, Feuchtenberger, M, Schwaneck, E, Wallace, S J, Cockell, S, Wilson-Kanamori, J, Ramachandran, P, Kho, C, Kendall, T J, Leblond, A-L, Keppler, S J, Bielecki, P, Steiger, K, Hofmann, M, Rippe, K, Zitzlesberger, H, Weber, A, Malek, N, Lüdde, T, Vucur, M, Augustin, H G, Flavell, R, Parnas, O, Rad, R, Pabst, O, Henderson, N C, Huber, S, Macpherson, A, Knolle, P, Claasen, M, Geier, A, Trautwein, C, Unger, K, Elinav, E, Waisman, A, Abdullah, Z, Haller, D, Tacke, F, Anstee, Q M & Heikenwalder, M 2023, ' Intestinal B-cells license metabolic T-cell activation in NASH microbiota/antigen-independently and contribute to fibrosis by IgA-FcR signalling ', Journal of Hepatology . https://doi.org/10.1016/j.jhep.2023.04.037

BACKGROUND & AIMS: The progression of nonalcoholic steatohepatitis (NASH) to fibrosis and hepatocellular carcinoma (HCC) is aggravated by auto-aggressive T cells. The gut-liver axis contributes to NASH, but the mechanisms involved and the consequence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e25f605ee9738f8f6026a70bbfe8ba

Mixed HCC-CCA originates from hepatic progenitor cells, is dependent on IL6 singling and is ablated by senolytic agents

Autor: Nofar Rosenberg, Matthias Van Haele, Maria Garcia Beccaria, Mirian Fernández-Vaquero, Danijela Heide, Neta Barashi, Amnon Peled, Yuval Nevo, Shrona Elgavish, Dirk Schmist-Arras, Hanan Edler, Alina Simerzin, Michal Shoshkes-Carmel, Klaus Kaestner, Hilla Giladi, Stefan Rose-John, Tania Roskams, Mathias Heikenwälder, Eithan Galun

Publikováno v: Journal of Hepatology. 77:S47

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf77ef50be119a18e91c843ce780e22b
https://doi.org/10.1016/s0168-8278(22)00505-0

Therapeutic inhibition of TRF1 impairs the growth of p53‐deficient K‐RasG12V‐induced lung cancer by induction of telomeric DNA damage

Autor: María García‐Beccaria, Paula Martínez, Marinela Méndez‐Pertuz, Sonia Martínez, Carmen Blanco‐Aparicio, Marta Cañamero, Francisca Mulero, Chiara Ambrogio, Juana M Flores, Diego Megias, Mariano Barbacid, Joaquín Pastor, Maria A Blasco

Publikováno v: EMBO Molecular Medicine, Vol 7, Iss 7, Pp 930-949 (2015)

Abstract Telomeres are considered anti‐cancer targets, as telomere maintenance above a minimum length is necessary for cancer growth. Telomerase abrogation in cancer‐prone mouse models, however, only decreased tumor growth after several mouse gen

Externí odkaz: https://doaj.org/article/9d184454ee944308a85f34b3438cb76b