Medium-Term Culture of Primary Oral Squamous Cell Carcinoma in a Three- Dimensional Model: Effects on Cell Survival Following Topical 5-Fluororacile Delivery by Drug-Loaded Matrix Tablets

Autor: Maria Gabriella Siragusa, Vito Marcianò, Domenico Compilato, Fabio Bucchieri, Giulia Giandalia, Antonella Marino Gammazza, Viviana De Caro, Libero Italo Giannola, Giovanni Zummo, Alessandro Pitruzzella, Donna E. Davies, Alberto Fucarino, Carlo Paderni, Stephen T. Holgate, Felicia Farina, Giuseppina Campisi

Publikováno v: Current Pharmaceutical Design. 18:5411-5420

Since the activity of several conventional anticancer drugs is restricted by resistance mechanisms and dose-limiting side-effects, the design of formulations for local application on malignant lesions seems to be an efficient and promising drug deliv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c47e6e906249b1a51a245f551605b987
https://doi.org/10.2174/138161212803307536

5-Fluorouracil Buccal Tablets for Locoregional Chemotherapy of Oral Squamous Cell Carcinoma: Formulation, Drug Release and Histological Effects on Reconstituted Human Oral Epithelium and Porcine Buccal Mucosa

Autor: Ada Maria Florena, Libero Italo Giannola, Giuseppina Campisi, Giulia Giandalia, Carlo Paderni, Maria Gabriella Siragusa, Viviana De Caro

Publikováno v: Scopus-Elsevier

5-Fluorouracil (5-FU) is currently used for treatment of oral squamous cell carcinoma (OSCC). 5-FU is given by i.v. although the systemic administration is associated with severe toxic effects and no topical formulations of 5-FU for buccal drug deliv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::331eafef64c40566099ffd2d0dcfe66a
https://doi.org/10.2174/156720110791011792

N-valproyl-L-tryptophan for CNS-targeting: synthesis, characterization and efficacy in vitro studies of a new potential antiepileptic drug

Autor: Pierangelo Sardo, Viviana De Caro, Giuseppe Ferraro, Liliana Lamartina, Valerio Rizzo, Maria Gabriella Siragusa, Fabio Carletti, Simonetta Friscia, Giulia Giandalia, Libero Italo Giannola

Publikováno v: Medicinal chemistry (Shariqah (United Arab Emirates)). 7(1)

A new aminoacidic derivative of valproic acid (VPA) has been synthesized and characterized by analytical and spectral data. The rationale for the preparation of such potential antiepileptic agent is based on the observation that chemical combination

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d80529da26dd35fd11003cf029f1bed2
https://pubmed.ncbi.nlm.nih.gov/21235514

Carbamazepine transbuccal delivery: the histo-morphological features of reconstituted human oral epithelium and buccal porcine mucosae in the transmucosal permeation

Autor: Ada Maria Florena, Claudio Tripodo, Libero Italo Giannola, Giuseppina Campisi, Lorenzo Lo Muzio, R. Saccone, Maria Gabriella Siragusa, Carlo Paderni

Publikováno v: Scopus-Elsevier
Europe PubMed Central

Transbuccal drug delivery is an attractive way of administration since several well-known advantages are provided, especially with respect to peroral management. Carbamazepine (CBZ) is an anticonvulsant which is useful in controlling neuropathic pain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ee484043f38717ec1d4ede75363535
https://pubmed.ncbi.nlm.nih.gov/19144275

Ocular gelling microspheres: in vitro precorneal retention time and drug permeation through reconstituted corneal epithelium

Autor: Viviana De Caro, Maria Gabriella Siragusa, Giulia Giandalia, Lorenzo Cordone, Libero Italo Giannola

Publikováno v: Journal of ocular pharmacology and therapeutics 24 (2008): 186–196.
info:cnr-pdr/source/autori:Giannola, LI; De Caro, V; Giandalia, G; Siragusa, MG; Cordone, L/titolo:Ocular gelling microspheres: In vitro precorneal retention time and drug permeation through reconstituted corneal epithelium/doi:/rivista:Journal of ocular pharmacology and therapeutics/anno:2008/pagina_da:186/pagina_a:196/intervallo_pagine:186–196/volume:24

Purpose: The model drug norfloxacin (NOR)was encapsulated into trehalose (TRH) and hydroxyethylcellulose(NAT) microspheres to obtain a novel gelling ophthalmic delivery system for prolonged release on corneal tissue. Methods: We assessed NOR release

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::919f45d16c2f7468d166278bb4518123
https://pubmed.ncbi.nlm.nih.gov/18355132