Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Maria G. McPhillips"'
Publikováno v:
Virus Research
Human papillomavirus type 16 (HPV16) infects anogenital epithelia and is the etiological agent of cervical cancer. We showed previously that HPV16 infection regulates the key splicing/alternative splicing factor SF2/ASF and that virus late transcript
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::813fd31ef5f2de0dfa43a67992b5e970
https://doi.org/10.1016/j.virusres.2007.09.006
https://doi.org/10.1016/j.virusres.2007.09.006
Publikováno v:
Journal of Virology. 80:9530-9543
Bromodomain protein 4 (Brd4) has been identified as the cellular binding target through which the E2 protein of bovine papillomavirus type 1 links the viral genome to mitotic chromosomes. This tethering ensures retention and efficient partitioning of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb6f21cb3c8bd2755accf469fe9b63b
https://doi.org/10.1128/jvi.01105-06
https://doi.org/10.1128/jvi.01105-06
Autor:
Iain M. Morgan, Steven G. Milligan, Maria G. McPhillips, Thanaporn Veerapraditsin, Winifred Boner, Dimitra Karali, Sarah A. Cumming, Sheila V. Graham
Publikováno v:
Journal of Virology. 78:10598-10605
Pre-mRNA splicing occurs in the spliceosome, which is composed of small ribonucleoprotein particles (snRNPs) and many non-snRNP components. SR proteins, so called because of their C-terminal arginine- and serine-rich domains (RS domains), are essenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fa8bde2184140d28cfded135fe6763d
https://doi.org/10.1128/jvi.78.19.10598-10605.2004
https://doi.org/10.1128/jvi.78.19.10598-10605.2004
Autor:
Sheila V. Graham, Sarah A. Cumming, Steven G. Milligan, Thanaporn Veerapraditsin, Maria G. McPhillips
Publikováno v:
Journal of Virology. 77:5167-5177
The human papillomavirus (HPV) life cycle is tightly linked to differentiation of the squamous epithelia that it infects. Capsid proteins, and hence mature virions, are produced in the outermost layer of differentiated cells. As late gene transcripts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b334690aab9086c60a1c7b1236b06f0c
https://doi.org/10.1128/jvi.77.9.5167-5177.2003
https://doi.org/10.1128/jvi.77.9.5167-5177.2003
Publikováno v:
Biochemical Society Transactions. 34:1145-1147
HPV-16 (human papillomavirus type 16) is a small dsDNA (double-stranded DNA) virus which infects mucosal epithelial tissue of the cervix. Epithelial tissue is composed of a basal layer of cells, capable of division, and a number of suprabasal layers,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83d9d1ce951e1f463678715cfc11071a
https://doi.org/10.1042/bst0341145
https://doi.org/10.1042/bst0341145
For many papillomaviruses, the viral protein E2 tethers the viral genome to the host mitotic chromosomes to ensure persistent, long-term maintenance of the genome during cell division. Our previous studies of E2 proteins from different genera of papi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd824758bc0e26b1da835b72d941af54
https://europepmc.org/articles/PMC2612381/
https://europepmc.org/articles/PMC2612381/
Publikováno v:
Cell cycle (Georgetown, Tex.). 5(14)
Papillomavirus infections are long-lived and persistent. The circular DNA of the viral genome is maintained in dividing epithelial cells as an extrachromosomal element. The E2 protein of the virus binds to the viral genome and tethers it to mitotic c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da6880964bd8156247e3d31310316136
https://pubmed.ncbi.nlm.nih.gov/16861919
https://pubmed.ncbi.nlm.nih.gov/16861919
The bovine papillomavirus E2 protein maintains and segregates the viral extrachromosomal genomes by tethering them to cellular mitotic chromosomes. E2 interacts with a cellular bromodomain protein, Brd4, to mediate the segregation of viral genomes in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b613b215c16cb01bb008f9b7af96c8c6
https://europepmc.org/articles/PMC1168793/
https://europepmc.org/articles/PMC1168793/
Publikováno v:
Journal of virology. 79(8)
The papillomavirus transcriptional activator, E2, is involved in key functions of the viral life cycle. These include transcriptional regulation, viral DNA replication, and viral genome segregation. The transactivation domain of E2 is required for ea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b46da549613b156e6cd9698918ed897a
https://pubmed.ncbi.nlm.nih.gov/15795266
https://pubmed.ncbi.nlm.nih.gov/15795266
Publikováno v:
Trends in microbiology. 12(12)
Papillomaviruses segregate their genomes in dividing cells by tethering them to mitotic chromosomes via the viral E2 protein. A recent report has shown that this interaction is mediated by the cellular bromodomain protein Brd4. This discovery provide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca6b3b124904664a6ebc40e2bdda9a3d
https://pubmed.ncbi.nlm.nih.gov/15539109
https://pubmed.ncbi.nlm.nih.gov/15539109