Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Maria G. Beconi"'
Autor:
Daniel Elbaum, Maria G Beconi, Edith Monteagudo, Annalise Di Marco, Maria S Quinton, Kathryn A Lyons, Andrew Vaino, Steven Harper
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0192028 (2018)
In cells, phosphorylation of pantothenic acid to generate phosphopantothenic acid by the pantothenate kinase enzymes is the first step in coenzyme A synthesis. Pantothenate kinase 2, the isoform localized in neuronal cell mitochondria, is dysfunction
Externí odkaz:
https://doaj.org/article/c07328031f9c40e7ac21d7d5ae98a063
Autor:
Daniel Elbaum, Daniel O. Cicero, Paola Fezzardi, Annalise Di Marco, Steven J. Harper, Savina Malancona, Elena Bracacel, Andrea Vecchi, Ilaria Rossetti, Edith Monteagudo, Alina Ciammaichella, Giulio Auciello, Odalys Gonzalez Paz, Maria G. Beconi
Publikováno v:
Journal of Medicinal Chemistry. 63:15785-15801
Mutations in the human PANK2 gene are implicated in neurodegenerative diseases such as pantothenate kinase-associated neurodegeneration (PKAN) and result in low levels of coenzyme-A (CoA) in the CNS due to impaired production of phosphopantothenic ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c53c5a490a956c7c2db428b0dc609e43
https://doi.org/10.1021/acs.jmedchem.0c01531
https://doi.org/10.1021/acs.jmedchem.0c01531
Autor:
Daniel Elbaum, Maria Lucia de Leonibus, Camilla Montesano, Laura Orsatti, Fabio Bonelli, Maria G. Beconi, Roberto Speziale, Edith Monteagudo, Paola Fezzardi
Publikováno v:
Journal of Chromatography B. 1083:57-62
Acetyl coenzyme A is involved in several key metabolic pathways. Its concentration can vary considerably in response to physiological or pathological conditions making it a potentially valuable biomarker. However, little information about the measure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d54c9f1c055ecb654eea743e3e2556b
https://doi.org/10.1016/j.jchromb.2018.02.039
https://doi.org/10.1016/j.jchromb.2018.02.039
Autor:
Maria G. Beconi, Ravi Krishna Babu, Sophia Nguyen, Venkateshwar Rao, Vu P. Hong, Brian MacDonald, William J. Savage, Srikanth Venkatraman, Cecile Blaustein
Publikováno v:
Blood. 136:41-42
Hepcidin is known as the master regulator of systemic iron homeostasis with reduction in synthesis leading to the development of iron overload. Hepcidin gene expression is negatively modulated by matriptase-2 (MT-2), a liver-specific type II transmem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e092e0ba728551433688c50dec161a3c
https://doi.org/10.1182/blood-2020-138509
https://doi.org/10.1182/blood-2020-138509
Autor:
Cecile Blaustein, Sophia Nguyen, Mark Hixon, Maria G. Beconi, Christopher R. King, William J. Savage
Publikováno v:
Blood. 136:14-15
DISC-0974 is a humanized monoclonal anti-HJV antibody with high binding affinity for human, rat and cynomolgus monkey HJV (100 pM, 240 pM and 110 pM Kd, respectively) [Kovac 2016]. DISC-0974 inhibits the interaction between HJV and the key hepcidin r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::351ef233f642262e77aa568fef102eb2
https://doi.org/10.1182/blood-2020-138547
https://doi.org/10.1182/blood-2020-138547
Autor:
Cecile Blaustein, William J. Savage, Vu P. Hong, Srikanth Venkatraman, Brian MacDonald, Sophia Nguyen, Maria G. Beconi, Christopher R. King
Publikováno v:
Blood. 136:2-2
In diseases characterized by chronic inflammation, hepcidin levels are often elevated causing reduced transferrin-bound iron, reduced erythroid iron availability, diminished erythropoiesis and anemia despite the presence of adequate iron stores. Hemo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6501140da11b1286856936219e3b03f
https://doi.org/10.1182/blood-2020-138720
https://doi.org/10.1182/blood-2020-138720
Autor:
Laura Orsatti, Roberto Speziale, Kathryn A. Lyons, Fulvia Caretti, Maria Vittoria Orsale, Edith Monteagudo, Maria G. Beconi, Fabio Bonelli, Maria Veneziano, Todd Herbst, Ignacio Munoz-Sanjuan, Celia Dominguez, Matteo Zini, Kelvin Chan, Leticia Toledo-Sherman
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 107:426-431
Neuroactive metabolites in the kynurenine pathway of tryptophan catabolism are associated with neurodegenerative disorders. Tryptophan is transported across the blood–brain barrier and converted via the kynurenine pathway to N-formyl- l -kynurenine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4572036f528eeda5c4833d5434d89f0d
https://doi.org/10.1016/j.jpba.2015.01.030
https://doi.org/10.1016/j.jpba.2015.01.030
Autor:
Donald F. Hora, Suzanne L. Ciccotto, James R. Reed, Stella H. Vincent, Christopher J. Kochansky, David Q. Liu, Shiyao Xu, Ralph A. Stearns, Maria G. Beconi, Charles S. Elmore, Yohannes Teffera, Yuan-Qing Xia
Publikováno v:
Drug Metabolism and Disposition. 35:525-532
The pharmacokinetics, metabolism, and excretion of sitagliptin [MK-0431; (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine], a potent dipeptidyl peptidase 4 inhibitor, were eva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::294ab689fa7f08ad97b8496dc34b69f8
https://doi.org/10.1124/dmd.106.013110
https://doi.org/10.1124/dmd.106.013110
Autor:
Hyun O. Ok, Tesfaye Biftu, Ann E. Weber, Scott D. Edmondson, William P. Feeney, Joseph K. Wu, Kelly Ann Pryor, George R. Lankas, Reshma A. Patel, Aleksandr Petrov, Xiaoping Zhang, Xiaoxia Qian, Nancy A. Thornberry, Dooseop Kim, Andrea Woods, Ranabir Sinha Roy, George J. Eiermann, Chi-Chung Chan, Dawn E. Ippolito, Maria G. Beconi, Lan Zhu, Leah Bitalac Reigle, Huaibing He, Dennis M. Zaller, Barbara Leiting, Kathryn A. Lyons
Publikováno v:
Diabetes. 54:2988-2994
Dipeptidyl peptidase (DPP)-IV inhibitors are a new approach to the treatment of type 2 diabetes. DPP-IV is a member of a family of serine peptidases that includes quiescent cell proline dipeptidase (QPP), DPP8, and DPP9; DPP-IV is a key regulator of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04d32fb4e0599d1cdc316ba006f027e4
https://doi.org/10.2337/diabetes.54.10.2988
https://doi.org/10.2337/diabetes.54.10.2988
Autor:
S. Edmonson, George A. Doss, Yohannes Teffera, J. Shang, Maria G. Beconi, Shiyao Xu, Ralph A. Stearns
Publikováno v:
Xenobiotica. 35:697-713
The aim was to investigate the metabolic activation potential of a pentafluorophenylethylamine derivative (compound I) in vitro in the rat and to identify the cytochrome P450 (CYP) enzymes that catalyse these metabolic activation processes. Reduced g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f77adc1aa18554a01fa05184a1d93e86
https://doi.org/10.1080/00498250500230479
https://doi.org/10.1080/00498250500230479