Zobrazeno 1 - 10
of 199
pro vyhledávání: '"Maria G Masucci"'
Autor:
Jinlin Li, Noemi Nagy, Jiangnan Liu, Soham Gupta, Teresa Frisan, Thomas Hennig, Donald P Cameron, Laura Baranello, Maria G Masucci
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009954 (2021)
Topoisomerases are essential for the replication of herpesviruses but the mechanisms by which the viruses hijack the cellular enzymes are largely unknown. We found that topoisomerase-II (TOP2) is a substrate of the Epstein-Barr virus (EBV) ubiquitin
Externí odkaz:
https://doaj.org/article/19987ba58b534c27bc4d47f405f3f9d1
Autor:
Soham Gupta, Päivi Ylä-Anttila, Tatyana Sandalova, Renhua Sun, Adnane Achour, Maria G Masucci
Publikováno v:
PLoS Pathogens, Vol 15, Iss 11, p e1008146 (2019)
The 14-3-3 molecular scaffolds promote type I interferon (IFN) responses by stabilizing the interaction of RIG-I with the TRIM25 ligase. Viruses have evolved unique strategies to halt this cellular response to support their replication and spread. He
Externí odkaz:
https://doaj.org/article/85ced8dfa3074c97863a92fe748c0c4e
Autor:
Soham Gupta, Päivi Ylä-Anttila, Simone Callegari, Ming-Han Tsai, Henri-Jacques Delecluse, Maria G Masucci
Publikováno v:
PLoS Pathogens, Vol 14, Iss 1, p e1006852 (2018)
The N-terminal domains of the herpesvirus large tegument proteins encode a conserved cysteine protease with ubiquitin- and NEDD8-specific deconjugase activity. The proteins are expressed during the productive virus cycle and are incorporated into inf
Externí odkaz:
https://doaj.org/article/44068917e38649e192a65f6e7a6fdcf8
Publikováno v:
PLoS Pathogens, Vol 13, Iss 4, p e1006338 (2017)
Post-translational modification by the Small Ubiquitin-like Modifier (SUMO) regulates a variety of cellular functions, and is hijacked by viruses to remodel the host cell during latent and productive infection. Here we have monitored the activity of
Externí odkaz:
https://doaj.org/article/27231e4088f041158b00ae359316c413
Publikováno v:
PLoS Pathogens, Vol 9, Iss 10, p e1003664 (2013)
The large tegument proteins of herpesviruses contain N-terminal cysteine proteases with potent ubiquitin and NEDD8-specific deconjugase activities, but the function of the enzymes during virus replication remains largely unknown. Using as model BPLF1
Externí odkaz:
https://doaj.org/article/55d18d0a347146babdef97ee65cd53de
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e62783 (2013)
The capacity of gamma-herpesviruses to establish lifelong infections is dependent on the expression of genome maintenance proteins (GMPs) that tether the viral episomes to cellular chromatin and allow their persistence in latently infected proliferat
Externí odkaz:
https://doaj.org/article/96285ff024c34565ba97f20c1608a929
Autor:
Jiangnan Liu, Noemi Nagy, Carlos Ayala-Torres, Francisco Aguilar-Alonso, Francisco Morais-Esteves, Shanshan Xu, Maria G. Masucci
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The strategies adopted by viruses to reprogram the translation and protein quality control machinery and promote infection are poorly understood. Here, we report that the viral ubiquitin deconjugase (vDUB)—encoded in the large tegument pro
Externí odkaz:
https://doaj.org/article/4cf2909b00384b029e5c0b1e22fa8b58
Autor:
Ximena Cortes-Bratti, Eugénie Bassères, Fabiola Herrera-Rodriguez, Silvia Botero-Kleiven, Giuseppe Coppotelli, Jens B Andersen, Maria G Masucci, Arne Holmgren, Esteban Chaves-Olarte, Teresa Frisan, Javier Avila-Cariño
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e16960 (2011)
BackgroundThioredoxin 80 (Trx80) is an 80 amino acid natural cleavage product of Trx, produced primarily by monocytes. Trx80 induces differentiation of human monocytes into a novel cell type, named Trx80-activated-monocytes (TAMs).Principal findingsI
Externí odkaz:
https://doaj.org/article/a3a2c7311ab8442e9881fec7e662edd7
Autor:
Julien Moretti, Patricia Chastagner, Stefano Gastaldello, Sara F Heuss, Annette M Dirac, René Bernards, Maria G Masucci, Alain Israël, Christel Brou
Publikováno v:
PLoS Biology, Vol 8, Iss 11, p e1000545 (2010)
Activation of the mammalian Notch receptor after ligand binding relies on a succession of events including metalloprotease-cleavage, endocytosis, monoubiquitination, and eventually processing by the gamma-secretase, giving rise to a soluble, transcri
Externí odkaz:
https://doaj.org/article/6aa96086ccfc4d12b2531f28cfae9c01
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12052 (2010)
The Epstein-Barr virus (EBV) encoded nuclear antigen (EBNA)-1 regulates virus replication and transcription, and participates in the remodeling of the cellular environment that accompanies EBV induced B-cell immortalization and malignant transformati
Externí odkaz:
https://doaj.org/article/631d0782f91d45b9937421ff60856bbe