Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Maria G Ledesma-Colunga"'
Autor:
Maria G. Ledesma-Colunga, Vanessa Passin, Maja Vujic Spasic, Lorenz C. Hofbauer, Ulrike Baschant, Martina Rauner
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Iron is an essential nutrient for all living organisms. Both iron deficiency and excess can be harmful. Bone, a highly metabolic active organ, is particularly sensitive to fluctuations in iron levels. In this study, we investigated the effec
Externí odkaz:
https://doaj.org/article/b2489d71ce5a4ab2901d9eeeb41f5e37
Autor:
Maria G. Ledesma-Colunga, Ulrike Baschant, Heike Weidner, Tiago C. Alves, Peter Mirtschink, Lorenz C. Hofbauer, Martina Rauner
Publikováno v:
Redox Biology, Vol 60, Iss , Pp 102616- (2023)
Objective: Rheumatoid arthritis is an inflammatory joint disease in which synovial iron deposition has been described. Transferrin receptor 2 (Tfr2) represents a critical regulator of systemic iron levels. Loss of Tfr2 function in humans and mice res
Externí odkaz:
https://doaj.org/article/b6dfec1e6fe644efb74ea14a924671ec
Publikováno v:
Bone Reports, Vol 14, Iss , Pp 100778- (2021)
Externí odkaz:
https://doaj.org/article/b0ae6baa6b5f4cd5a31e2786b17c65a2
Autor:
Maria G. Ledesma-Colunga, Norma Adán, Georgina Ortiz, Mariana Solís-Gutiérrez, Fernando López-Barrera, Gonzalo Martínez de la Escalera, Carmen Clapp
Publikováno v:
Arthritis Research & Therapy, Vol 19, Iss 1, Pp 1-16 (2017)
Abstract Background Prolactin (PRL) reduces joint inflammation, pannus formation, and bone destruction in rats with polyarticular adjuvant-induced arthritis (AIA). Here, we investigate the mechanism of PRL protection against bone loss in AIA and in m
Externí odkaz:
https://doaj.org/article/23930d7dcc264a84a87a18dbfefdbc8a
Autor:
Martina Rauner, Lorenz C. Hofbauer, Ulrike Baschant, Heike Weidner, Maria G. Ledesma-Colunga, Maja Vujic Spasic
Publikováno v:
Seminars in Hematology. 58:188-200
Well-controlled iron levels are indispensable for health. Iron deficiency is the most common cause of anemia, whereas iron overload, either hereditary or secondary due to disorders of ineffective erythropoiesis, causes widespread organ failure. Bone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3867148fb9ffcc7f5b09bdc37fdd448b
https://doi.org/10.1053/j.seminhematol.2021.06.002
https://doi.org/10.1053/j.seminhematol.2021.06.002
Autor:
Maria G. Ledesma-Colunga, Norma Adán, Carmen Clapp, Jose F García-Rodrigo, Zhijian Wu, Gonzalo Martínez de la Escalera, Georgina Ortiz
Publikováno v:
Laboratory Investigation. 100:1068-1079
Increased permeability and growth (angiogenesis) of blood vessels play a key role in joint swelling and pannus formation in inflammatory arthritis, a family of diseases influenced by reproductive hormones. The hormone prolactin (PRL) protects against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afbe0658b52a9fa411c5a3a201701a10
https://doi.org/10.1038/s41374-020-0432-5
https://doi.org/10.1038/s41374-020-0432-5
Autor:
Georgina Ortiz, Maria G Ledesma-Colunga, Zhijian Wu, Jose F García-Rodrigo, Norma Adan, Oscar F Martinez-Diaz, Ericka A De Los Ríos, Fernando López-Barrera, Gonzalo Martínez de la Escalera, Carmen Clapp
Publikováno v:
Endocrinology
Inflammatory arthritis defines a family of diseases influenced by reproductive hormones. Vasoinhibin, a fragment of the hormone prolactin (PRL), has antiangiogenic and proinflammatory properties. We recently showed that vasoinhibin reduces joint infl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::387b3a89e976c66c55a8b5a88092406a
https://pubmed.ncbi.nlm.nih.gov/35305012
https://pubmed.ncbi.nlm.nih.gov/35305012
Autor:
Ximena Castillo, Bibiana Moreno-Carranza, Carmen Clapp, Maria G. Ledesma-Colunga, Xarubet Ruiz-Herrera, Gonzalo Martínez de la Escalera, Edith Arnold, Zesergio Melo, Fernando López-Casillas
Publikováno v:
Neuroendocrinology. 109:152-164
Background: Vasoinhibin, a protein derived from prolactin, regulates various vascular functions including endothelial cell survival. Of note, vasoinhibin is present in the central nervous system, where it triggers neuroendocrine and behavioral respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d0a8b41413858dc5ccdb941d6c9b7af
https://doi.org/10.1159/000499507
https://doi.org/10.1159/000499507
Autor:
Andy Göbel, Sophie Pählig, Ben Wielockx, Xianyi Meng, Tilman D. Rachner, Andrew Wang, Aline Bozec, Timon E. Adolph, Maria G. Ledesma-Colunga, Anupam Sinha, Lorenz C. Hofbauer, Martina Rauner, Michal Grzybek, Julian Schwaerzler, Herbert Tilg, Sylvia Thiele, Nikolai Jaschke, Bettina Groetsch, Marc Gentzel
Publikováno v:
SSRN Electronic Journal.
Inflammation and cellular stress mutually regulate each other and are hallmarks of various diseases. The mechanistic basis of this interaction remains incompletely understood. Here, we report that proteostatic stress triggers the transcription and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::481896087d38c5a77bc87a89caca6c94
https://doi.org/10.2139/ssrn.3962446
https://doi.org/10.2139/ssrn.3962446
Autor:
Heike Weidner, Ulrike Baschant, Maria G. Ledesma-Colunga, Ina Kramer, Lorenz C. Hofbauer, Uwe Platzbecker, Martina Rauner
Publikováno v:
Bone Reports. 16:101382
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35f8ccd8e6a08557fe70891667ba0409
https://doi.org/10.1016/j.bonr.2022.101382
https://doi.org/10.1016/j.bonr.2022.101382