Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Maria G Buse"'
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e108963 (2014)
Chronic hyperglycemia induces insulin resistance by mechanisms that are incompletely understood. One model of hyperglycemia-induced insulin resistance involves chronic preincubation of adipocytes in the presence of high glucose and low insulin concen
Externí odkaz:
https://doaj.org/article/3d83709382a64172a8bdd5ff2bb96124
Publikováno v:
Molecular & Cellular Proteomics. 8:2733-2745
Insulin receptor substrate-1 (IRS-1) is a highly phosphorylated adaptor protein critical to insulin and IGF-1 receptor signaling. Ser/Thr kinases impact the metabolic and mitogenic effects elicited by insulin and IGF-1 through feedback and feed forwa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::177b60a06eb879e64e9fdd61648c418b
https://doi.org/10.1074/mcp.m900207-mcp200
https://doi.org/10.1074/mcp.m900207-mcp200
Publikováno v:
The FASEB Journal. 29
Posttranslational modifications of IRS1 mediate and modulate the pleiotropic effects elicited by insulin. O-GlcNAc modification of IRS1 correlates with attenuated insulin signaling. We identified O...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ef8099ea60e5b0409b60d19456ce7a3
https://doi.org/10.1096/fasebj.29.1_supplement.728.47
https://doi.org/10.1096/fasebj.29.1_supplement.728.47
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 291:E1274-E1280
Tribbles 3 (TRB3) is a recently recognized atypical inactive kinase that negatively regulates Akt activity in hepatocytes, resulting in insulin resistance. Recent reports link TRB3 to nutrient sensing and regulation of cell survival under stressful c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::949dd5221c362a308932bb25368bed2a
https://doi.org/10.1152/ajpendo.00117.2006
https://doi.org/10.1152/ajpendo.00117.2006
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 284:E424-E434
Increased flux through the hexosamine biosynthesis pathway has been implicated in the development of glucose-induced insulin resistance and may promote the modification of certain proteins with O-linked N-acetylglucosamine ( O-GlcNAc). L6 myotubes (a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f138afcfe1d9e2650911d958d6d1a1d
https://doi.org/10.1152/ajpendo.00382.2002
https://doi.org/10.1152/ajpendo.00382.2002
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 283:E241-E250
O-linked glycosylation on Ser/Thr with single N-acetylglucosamine ( O-GlcNAcylation) is a reversible modification of many cytosolic/nuclear proteins, regulated in part by UDP-GlcNAc levels. Transgenic (T) mice that overexpress GLUT1 in muscle show in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8db12c98a4a2f0b649346521c0ad3bbc
https://doi.org/10.1152/ajpendo.00060.2002
https://doi.org/10.1152/ajpendo.00060.2002
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 282:E497-E506
3T3-L1 adipocytes develop insulin-resistant glucose transport upon preincubation with high glucose or glucosamine, provided insulin (0.6 nM) is present during preincubation. Insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol (PI) 3-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72c79e1aeea76b27667b71734183e2e1
https://doi.org/10.1152/ajpendo.00438.2001
https://doi.org/10.1152/ajpendo.00438.2001
Publikováno v:
Journal of Biological Chemistry. 277:3809-3812
Preincubation of 3T3-L1 adipocytes in high glucose or glucosamine decreases acute insulin (100 nm)-stimulated glucose transport provided that insulin (0.6 nm) is included during preincubation. GLUT4 expression is unchanged (Nelson, B. A., Robinson, K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5774e8e77f076a391f7778cf4e2d206
https://doi.org/10.1074/jbc.c100645200
https://doi.org/10.1074/jbc.c100645200
Publikováno v:
Diabetes. 50:2419-2424
Glutamine:fructose-6-phosphate amidotransferase(GFAT) is the rate-limiting enzyme of the hexosamine synthesis pathway. Products of this pathway have been implicated in insulin resistance and glucose toxicity. GFAT1 is ubiquitous, whereas GFAT2 is exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35a44edf4b274e52d79f3a2b10d4ac09
https://doi.org/10.2337/diabetes.50.11.2419
https://doi.org/10.2337/diabetes.50.11.2419
Publikováno v:
Metabolism. 50:1063-1069
Oxidative stress has been implicated in glucose toxicity. We tested the hypothesis that certain antioxidants may prevent insulin-resistant glucose transport that develops in adipocytes after sustained exposure to high glucose, provided insulin is pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef105a7f1ba6c29a397d29ad6b05464
https://doi.org/10.1053/meta.2001.25601
https://doi.org/10.1053/meta.2001.25601