Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Maria Faelth-Savitski"'
Autor:
Pu Qin, Pelin Arabacilar, Roberta E. Bernard, Weike Bao, Alan R. Olzinski, Yuanjun Guo, Hind Lal, Stephen H. Eisennagel, Michael C. Platchek, Wensheng Xie, Julius del Rosario, Mohamad Nayal, Quinn Lu, Theresa Roethke, Christine G. Schnackenberg, Fe Wright, Michael P. Quaile, Wendy S. Halsey, Ashley M. Hughes, Ganesh M. Sathe, George P. Livi, Robert B. Kirkpatrick, Xiaoyan A. Qu, Deepak K. Rajpal, Maria Faelth Savitski, Marcus Bantscheff, Gerard Joberty, Giovanna Bergamini, Thomas L. Force, Gregory J. Gatto, Erding Hu, Robert N. Willette
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 5 (2017)
BackgroundThe amino acid response (AAR) is an evolutionarily conserved protective mechanism activated by amino acid deficiency through a key kinase, general control nonderepressible 2. In addition to mobilizing amino acids, the AAR broadly affects ge
Externí odkaz:
https://doaj.org/article/1c805dc589c7489c9f517443145877c9
Autor:
Nils Kurzawa, Marcus Bantscheff, Mikhail M. Savitski, Eugenia Stonehouse, Maria Faelth-Savitski, Holger Franken, Bianca Heller, Christina Rau, Jessica Perrin, Anna Rutkowska, H. Christian Eberl, Johanna Vappiani, Daniel C. Sévin, Isabelle Becher, Katrin Strohmer, Jana Krause, Thilo Werner, Douglas W. Thomson, Wolfgang Huber, Daniel Poeckel, Giovanna Bergamini, Mathias Kalxdorf, Dorothee Childs
Publikováno v:
Nature Biotechnology. 38:303-308
Monitoring drug-target interactions with methods such as the cellular thermal-shift assay (CETSA) is well established for simple cell systems but remains challenging in vivo. Here we introduce tissue thermal proteome profiling (tissue-TPP), which mea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bfbb2905022996925879a27350cf5f8
https://doi.org/10.1038/s41587-019-0388-4
https://doi.org/10.1038/s41587-019-0388-4
Autor:
Johanna Vappiani, Mikhail M. Savitski, Maria Faelth-Savitski, H. Christian Eberl, Dorothee Childs, Bianca Heller, Wolfgang Huber, Holger Franken, Jessica Perrin, Nils Kurzawa, Christina Rau, Daniel C. Sévin, Jana Krause, Marcus Bantscheff, Eugenia Stonehouse, Douglas W. Thomson, Daniel Poeckel, Anna Rutkowska, Giovanna Bergamini, Katrin Strohmer, Mathias Kalxdorf, Thilo Werner
Studying biological processes at a molecular level and monitoring drug-target interactions is established for simple cell systems but challenging in vivo. We introduce and apply a methodology for proteome-wide thermal stability measurements to charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af7eb2478837b12c2632cb21c39351a
https://doi.org/10.1101/500306
https://doi.org/10.1101/500306
Autor:
Natasha Routly, Giovanna Bergamini, Jeffrey L. Gustafson, Ko Eunhwa, Kristoffer Famm, Paola Grandi, John J. Flanagan, Daniel P. Bondeson, Maria Faelth-Savitski, Afjal Hussain Miah, Nico Zinn, Deborah A. Gordon, Craig M. Crews, Laurens Kruidenier, Paul S. Carter, Ian Edward David Smith, Marcus Bantscheff, Alina Mares, Dennis L. Buckley, John D. Harling, Linda N. Casillas, Sebastien Andre Campos, Ryan R. Willard, Bartholomew J. Votta, Willem den Besten, Satoko Shimamura, Carly S. Cox, Ian Churcher, Katie E Mulholland
Publikováno v:
Nature Chemical Biology. 11:611-617
The current predominant therapeutic paradigm is based on maximizing drug-receptor occupancy to achieve clinical benefit. This strategy, however, generally requires excessive drug concentrations to ensure sufficient occupancy, often leading to adverse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91cded625a4a254a72d85709b447840b
https://doi.org/10.1038/nchembio.1858
https://doi.org/10.1038/nchembio.1858
Autor:
Deepak K. Rajpal, Pelin Arabacilar, Julius del Rosario, Ganesh M. Sathe, Erding Hu, Yuanjun Guo, Stephen H. Eisennagel, Quinn Lu, Maria Faelth Savitski, Gatto Gregory J, Roberta E. Bernard, Ashley M. Hughes, Mohamad Nayal, Wensheng Xie, Robert N. Willette, Pu Qin, Theresa J. Roethke, George P. Livi, Xiaoyan Qu, Michael P. Quaile, Gerard Joberty, Weike Bao, Robert B. Kirkpatrick, Alan R. Olzinski, Marcus Bantscheff, Christine G. Schnackenberg, Wendy S. Halsey, Thomas Force, Hind Lal, Fe Wright, Michael Platchek, Giovanna Bergamini
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The amino acid response ( AAR ) is an evolutionarily conserved protective mechanism activated by amino acid deficiency through a key kinase, general control nonderepressible 2. In addition to mobilizing amino acids, the AAR broadly affects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c4f7d6e43b4dca4ee10ebc8ec0a651
https://pubmed.ncbi.nlm.nih.gov/28487390
https://pubmed.ncbi.nlm.nih.gov/28487390
Autor:
Ilse Dewachter, Jean-Noël Octave, Bruno Barbosa de Vasconcelos, Pascal Kienlen-Campard, Marcus Bantscheff, Nathalie Pierrot, Alexandre Vanoosthuyse, Ilie-Cosmin Stancu, Gerard Drewes, Diederik Moechars, Gerard Joberty, Maria Faelth-Savitski, Arjan Buist, Peng Wang
Publikováno v:
Acta Neuropathologica
Dysregulated proteostasis is a key feature of a variety of neurodegenerative disorders. In Alzheimer's disease (AD), progression of symptoms closely correlates with spatiotemporal progression of Tau aggregation, with "early" oligomeric Tau forms rath
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6ce83a112578fad77432f9727b22b7e
http://hdl.handle.net/1942/23691
http://hdl.handle.net/1942/23691
Autor:
Chad Quinn, Angela Smallwood, Beth Pietrak, Huizhen Zhao, Luis A. Carvajal, Pat Brady, Hideki Makishima, Alexander Joseph Reif, Jaroslaw P. Maciejewski, Maximilian Christopeit, Chaya Duraiswami, Nicholas D. Adams, Enoch Gao, Swathi-Rao Narayanagari, Cynthia M. Rominger, Yun-Ruei Kao, Boris Bartholdy, Ken Wiggall, Nestor O. Concha, Laura Barreyro, Ulrich Steidl, Maria Faelth-Savitski, Heng Rui Wang, Benjamin Schwartz, Hongwei Qi, Kelly Mitchell, Jessy Cartier, Britta Will, Gerard Joberty, Alan R. Rendina, Marcus Bantscheff, Gerard Drewes, Ujunwa C. Okoye-Okafor, Stan Schmidt, Amit Verma, Iléana Antony-Debré, Michael T. McCabe, Elisabeth Paietta
Publikováno v:
Blood. 126:787-787
Mutations in the isocitrate dehydrogenase 1 (IDH1) gene are known driver mutations in acute myeloid leukemia (AML) and other cancer types. Patient outcomes in AML have remained poor, especially for patients above 60 years of age who typically do not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::291d49315ec8b848650a5e7a96a7ec61
https://doi.org/10.1182/blood.v126.23.787.787
https://doi.org/10.1182/blood.v126.23.787.787
Autor:
Amit Verma, Marcus Bantscheff, Beth Pietrak, Maria Faelth-Savitski, Ujunwa C. Okoye-Okafor, Nestor O. Concha, Laura Barreyro, Elisabeth Paietta, Enoch Gao, Huizhen Zhao, Stan Schmidt, Angela Smallwood, Pat Brady, Chad Quinn, Alan R. Rendina, Nicholas D. Adams, Luis A. Carvajal, Britta Will, Heng Rui Wang, Gerard Drewes, Alexander Joseph Reif, Gerard Joberty, Maximilian Christopeit, Jessy Cartier, J. Maciejewski, Ulrich Steidl, Chaya Duraiswami, Swathi-Rao Narayanagari, Cynthia M. Rominger, Kelly Mitchell, Yun-Ruei Kao, Iléana Antony-Debré, Michael T. McCabe, Hongwei Qi, Benjamin Schwartz, Boris Bartholdy, Ken Wiggall
Publikováno v:
Molecular Cancer Therapeutics. 14:C38-C38
Mutations in the isocitrate dehydrogenase 1 (IDH1) gene are known driver mutations in acute myeloid leukemia (AML) and other cancer types. AML is hallmarked by a differentiation block and patient outcomes remain poor, especially for patients above 60
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8df21879f86b9d4f1409309659e95a9f
https://doi.org/10.1158/1535-7163.targ-15-c38
https://doi.org/10.1158/1535-7163.targ-15-c38