Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Maria F. Pino"'
Autor:
Jake W. Willows, Gilian Gunsch, Emma Paradie, Magdalena Blaszkiewicz, Jeffrey R. Tonniges, Maria F. Pino, Steven R. Smith, Lauren M. Sparks, Kristy L. Townsend
Publikováno v:
iScience, Vol 26, Iss 3, Pp 106189- (2023)
Summary: Peripheral neuropathy, which can include axonal degeneration and/or demyelination, impacts adipose tissues with obesity, diabetes, and aging. However, the presence of demyelinating neuropathy had not yet been explored in adipose. Both demyel
Externí odkaz:
https://doaj.org/article/0a17f561f6304c6aa76f43e79b802080
Autor:
Katie L. Whytock, Adeline Divoux, Yifei Sun, Meghan Hopf, Reichelle X. Yeo, Maria F. Pino, GongXin Yu, Steven R. Smith, Martin J. Walsh, Lauren M. Sparks
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 102054- (2023)
Summary: Automated single-cell dispensing is incompatible with white adipose tissue (WAT) due to lipid-laden adipocytes. Single-nuclei RNA-Seq permits transcriptional profiling of all cells from WAT. Human WAT faces unique technical challenges in iso
Externí odkaz:
https://doaj.org/article/6f05c012201949db8ce2f85ec5f3f189
Autor:
Rick B. Vega, Bram Brouwers, Stephanie A. Parsons, Natalie A. Stephens, Maria F. Pino, Andrew Hodges, Fanchao Yi, Gongxin Yu, Richard E. Pratley, Steven R. Smith, Lauren M. Sparks
Publikováno v:
Physiological Reports, Vol 8, Iss 12, Pp n/a-n/a (2020)
Abstract Exercise training and physical activity are known to be associated with high mitochondrial content and oxidative capacity in skeletal muscle. Metabolic diseases including obesity and insulin resistance are associated with low mitochondrial c
Externí odkaz:
https://doaj.org/article/d278b58f8ce84e6e841daaf6879936d6
Autor:
Jake W. Willows, Gilian Gunsch, Emma Paradie, Magdalena Blaszkiewicz, Jeffrey R. Tonniges, Maria F. Pino, Steven R. Smith, Lauren M. Sparks, Kristy L. Townsend
Peripheral neuropathy is a pathophysiological state of nerve degeneration and loss of tissue innervation. The most prominent cause of small fiber neuropathy is diabetes which can be demyelinating in nature, but this has not yet been explored in adipo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1bfbd5aa49b53f700c8ce9f1d16b507
https://doi.org/10.1101/2022.08.25.505298
https://doi.org/10.1101/2022.08.25.505298
Autor:
Reichelle X. Yeo, Pieter J. Dijkstra, Flavia G. De Carvalho, Fanchao Yi, Maria F. Pino, Steven R. Smith, Lauren M. Sparks
Publikováno v:
American journal of physiology. Cell physiology. 323(2)
The impact of aerobic training on human skeletal muscle cell (HSkMC) mitochondrial metabolism is a significant research gap, critical to understanding the mechanisms by which exercise augments skeletal muscle metabolism. We therefore assessed mitocho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82249b48537e1c4e4e1ef49d5780eecf
https://pubmed.ncbi.nlm.nih.gov/35785986
https://pubmed.ncbi.nlm.nih.gov/35785986
Autor:
Gongxin Yu, Rick B. Vega, Richard E. Pratley, Lauren M. Sparks, Bram Brouwers, Steven R. Smith, Maria F. Pino, Natalie A. Stephens, Andrew Hodges, Stephanie A. Parsons, Fanchao Yi
Publikováno v:
Physiological Reports
Physiological Reports, Vol 8, Iss 12, Pp n/a-n/a (2020)
Physiological Reports, Vol 8, Iss 12, Pp n/a-n/a (2020)
Exercise training and physical activity are known to be associated with high mitochondrial content and oxidative capacity in skeletal muscle. Metabolic diseases including obesity and insulin resistance are associated with low mitochondrial capacity i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59705183a4075800ed65eccb6e6ffd20
http://europepmc.org/articles/PMC7305239
http://europepmc.org/articles/PMC7305239
Publikováno v:
International Journal of Obesity. 41:1646-1653
Despite successful preclinical testing, 85% of early clinical trials for novel drugs fail. Most futilities originate from molecular mechanisms of the drug(s) tested. It is critically important to develop validated human cell-based model systems in wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41284114c2f3bb5a29a90172c5b638be
https://doi.org/10.1038/ijo.2017.155
https://doi.org/10.1038/ijo.2017.155
Publikováno v:
Obesity. 24:2467-2470
Objective Exercise training (training) effects on white adipose tissue (WAT) thermogenic and oxidative capacities in humans are inconclusive. This study aimed to investigate whether an active lifestyle is characterized by thermogenic and/or oxidative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41152fdce58b21d04c14cf01da0c0872
https://doi.org/10.1002/oby.21669
https://doi.org/10.1002/oby.21669
Autor:
Timothy A. McKinsey, Maria A. Cavasin, Pilar Londono, Sheila Collins, Dianxin Liu, Tianjing Hu, Maria F. Pino, Steven R. Smith, Rushita A. Bagchi, Edward Seto, Lei Sun, Kunhua Song, Matthew S. Stratton, Lauren M. Sparks, Ying-Hsi Lin, Philipp E. Scherer, Bradley S. Ferguson
Publikováno v:
JCI Insight. 3
Little is known about the biological function of histone deacetylase 11 (HDAC11), which is the lone class IV HDAC. Here, we demonstrate that deletion of HDAC11 in mice stimulates brown adipose tissue (BAT) formation and beiging of white adipose tissu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f67a30ae84a4b2190ab96f9e4695aaf
https://doi.org/10.1172/jci.insight.120159
https://doi.org/10.1172/jci.insight.120159
Autor:
Lauren M. Sparks, Fanchao Yi, Natalie A. Stephens, Andrew Hodges, Bret H. Goodpaster, Steven R. Smith, Richard E. Pratley, Maria F. Pino
Publikováno v:
Diabetes. 67
The effects of exercise training on the skeletal muscle (SKM) lipidome and mitochondrial function have not been thoroughly explored in individuals with type 2 diabetes (T2D). We investigated the effects of exercise training on molecular signatures wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5dac42357e91b2008183d7b0fa2396c1
https://doi.org/10.2337/db18-70-or
https://doi.org/10.2337/db18-70-or