Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Maria F. Newhardt"'
1
Akademický článek
Insulin signaling alters antioxidant capacity in the diabetic heart
Autor: Satoshi Matsuzaki, Craig Eyster, Maria F. Newhardt, Jennifer R. Giorgione, Caroline Kinter, Zachary T. Young, Michael Kinter, Kenneth M. Humphries
Publikováno v: Redox Biology, Vol 47, Iss , Pp 102140- (2021)
Diabetic cardiomyopathy is associated with an increase in oxidative stress. However, antioxidant therapy has shown a limited capacity to mitigate disease pathology. The molecular mechanisms responsible for the modulation of reactive oxygen species (R
Externí odkaz: https://doaj.org/article/2213bc327ff1448cbd122f6bbf80ee4e
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2
Akademický článek
Cardiac Insulin Signaling Regulates Glycolysis Through Phosphofructokinase 2 Content and Activity
Autor: Lee B. Bockus, Satoshi Matsuzaki, Shraddha S. Vadvalkar, Zachary T. Young, Jennifer R. Giorgione, Maria F. Newhardt, Michael Kinter, Kenneth M. Humphries
Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 12 (2017)
BackgroundThe healthy heart has a dynamic capacity to respond and adapt to changes in nutrient availability. Diabetes mellitus disrupts this metabolic flexibility and promotes cardiomyopathy through mechanisms that are not completely understood. Phos
Externí odkaz: https://doaj.org/article/16b32246753649a0b935f2759f21a632
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3
The loss of cardiac SIRT3 decreases metabolic flexibility and proteostasis in an age-dependent manner
Autor: Ping Li, Maria F. Newhardt, Satoshi Matsuzaki, Craig Eyster, Atul Pranay, Frederick F. Peelor, Albert Batushansky, Caroline Kinter, Kumar Subramani, Sandeep Subrahmanian, Jasimuddin Ahamed, Pengchun Yu, Michael Kinter, Benjamin F. Miller, Kenneth M. Humphries
Publikováno v: GeroScience. 45:983-999
SIRT3 is a longevity factor that acts as the primary deacetylase in mitochondria. Although ubiquitously expressed, previous global SIRT3 knockout studies have shown primarily a cardiac-specific phenotype. Here, we sought to determine how specifically
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::028d8a219d1235fa84aa9a88388f57cd
https://doi.org/10.1007/s11357-022-00695-0
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5
Enhancing cardiac glycolysis causes an increase in PDK4 content in response to short-term high-fat diet
Autor: Zachary T. Young, Luke I. Szweda, Satoshi Matsuzaki, Maria F. Newhardt, Albert Batushansky, Kenneth M. Humphries, Ngun Cer Chin, Michael Kinter, Melinda West
Publikováno v: J Biol Chem
The healthy heart has a dynamic capacity to respond and adapt to changes in nutrient availability. Metabolic inflexibility, such as occurs with diabetes, increases cardiac reliance on fatty acids to meet energetic demands, and this results in deleter
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c76dfd9c38f6fbc4b3c1fe7ad5c40a9
https://doi.org/10.1074/jbc.ra119.010371
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7
Insulin signaling alters antioxidant capacity in the diabetic heart
Autor: Michael Kinter, Craig Eyster, Jennifer R. Giorgione, Satoshi Matsuzaki, Kenneth M. Humphries, Zachary T. Young, Caroline S. Kinter, Maria F. Newhardt
Publikováno v: Redox Biology, Vol 47, Iss, Pp 102140-(2021)
Redox Biology
Diabetic cardiomyopathy is associated with an increase in oxidative stress. However, antioxidant therapy has shown a limited capacity to mitigate disease pathology. The molecular mechanisms responsible for the modulation of reactive oxygen species (R
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7854ebe1b376ca712f9264fee0a12d78
https://doi.org/10.1016/j.redox.2021.102140
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8
GC-MS metabolic profiling reveals Fructose-2,6-bisphosphate regulates branched chain amino acid metabolism in the heart during fasting
Autor: Melinda West, Timothy M. Griffin, Maria F. Newhardt, Albert Batushansky, Kenneth M. Humphries, Satoshi Matsuzaki
INTRODUCTION: As an insulin sensitive tissue, the heart decreases glucose usage during fasting. This response is mediated, in part, by decreasing phosphofructokinase-2 (PFK-2) activity and levels of its product fructose-2,6-bisphosphate. However, the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba0f12957d20e34e8737a575b87ace7
https://europepmc.org/articles/PMC6478396/
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10
Effect of Long-Term Green Tea Polyphenol Supplementation on Bone Architecture, Turnover, and Mechanical Properties in Middle-Aged Ovariectomized Rats
Autor: Brenda J. Smith, Michael D. Tomison, Xiao Song, Jia-Sheng Wang, Lili Tang, Jay J. Cao, Chwan-Li Shen, Kylie A. Corry, Maria F. Newhardt, Ming-Chien Chyu, Jiliang Li
Publikováno v: Calcified tissue international. 104(3)
We investigated the effects of 6-month green tea polyphenols (GTP) supplementation on bone architecture, turnover, and mechanical properties in middle-aged ovariectomized (OVX) rats. Female rats were sham-operated (n = 39, 13/group) or OVX (n = 143,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6d380a488ffe9aad09901fe34130330
https://pubmed.ncbi.nlm.nih.gov/30413854
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