Výsledky vyhledávání - "Maria F. Dutreil"

A novel tissue culture model for evaluating the effect of aging on stem cell fate in adult microvascular networks

Autor: Maria F. Dutreil, Ryan L. Fishel, Bruce A. Bunnell, Nicholas A. Hodges, Walter L. Murfee, Mohammad S. Azimi, Adam J. Katz, Jessica M. Motherwell, Matthew Nice

Publikováno v: GeroScience

In vitro models of angiogenesis are valuable tools for understanding the underlying mechanisms of pathological conditions and for the preclinical evaluation of therapies. Our laboratory developed the rat mesentery culture model as a new tool for inve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d009ca9c51e85c4ccc4fdf20020253f
https://doi.org/10.1007/s11357-020-00178-0

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Human Adipose Stromal/Stem Cells from Obese Donors Show Reduced Efficacy in Halting Disease Progression in the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis

Autor: Bruce A. Bunnell, Annie C. Bowles, Jeffrey M. Gimble, Joseph P. Morand, Amy L. Strong, Maria F. Dutreil, Rachel M. Wise

Publikováno v: Stem Cells. 34:614-626

Multiple sclerosis is an autoimmune disease that affects the white matter of the central nervous system and involves inflammation and demyelination. The recent advances in our understanding of adipose-derived stromal/stem cells (ASCs) and the utiliza

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccd59eb36eac719a0958354866e2b440
https://doi.org/10.1002/stem.2272

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Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury

Autor: Kristina Go, Luis A. Ortiz, Cheryl L. Fattman, Amitabh C Pandey, Maria F. Dutreil, Donald G. Phinney, German Torres

Publikováno v: Proceedings of the National Academy of Sciences. 104:11002-11007

Mesenchymal stem cells (MSCs) have been exploited as cellular vectors to treat a wide array of diseases but the mechanisms responsible for their therapeutic effect remain indeterminate. Previously, we reported that MSCs inhibit bleomycin (BLM)-induce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae57aa61ecd6dac47a9955047ab9416c
https://doi.org/10.1073/pnas.0704421104

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Leptin produced by obese adipose stromal/stem cells enhances proliferation and metastasis of estrogen receptor positive breast cancers

Autor: Bruce A. Bunnell, Maria F. Dutreil, Dorothy T. Pei, Brandi A. Biagas, Jason F. Ohlstein, Matthew E. Burow, H. Alan Tucker, Amy L. Strong, Jeffrey M. Gimble, Annie C. Bowles, Claire B. Llamas, Shijia Zhang, Lyndsay V. Rhodes

Publikováno v: Breast Cancer Research : BCR

Introduction The steady increase in the incidence of obesity among adults has been paralleled with higher levels of obesity-associated breast cancer. While recent studies have suggested that adipose stromal/stem cells (ASCs) isolated from obese women

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed1a66d5bc3e8762f8ed12f25ded18cd
http://europepmc.org/articles/PMC4541745

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Age- and dose-related effects on MSC engraftment levels and anatomical distribution in the central nervous systems of nonhuman primates: identification of novel MSC subpopulations that respond to guidance cues in brain

Autor: Iryna A. Isakova, Donald G. Phinney, Jason Dufour, Kate C. Baker, Dina Gaupp, Maria F. Dutreil

Publikováno v: Stem cells (Dayton, Ohio). 25(12)

Mesenchymal stem cells (MSCs) have demonstrated efficacy as therapeutic vectors in rodent models of neurological diseases, but few studies have evaluated their safety and efficacy in a relevant large animal model. Previously, we reported that MSCs tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9484712ffdd2ce8abefffdf134c020be
https://pubmed.ncbi.nlm.nih.gov/17932418

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Murine mesenchymal stem cells transplanted to the central nervous system of neonatal versus adult mice exhibit distinct engraftment kinetics and express receptors that guide neuronal cell migration

Autor: Donald G. Phinney, Wen Tzu Lai, Dina Gaupp, Iryna A. Isakova, Melody Baddoo, Maria F. Dutreil

Publikováno v: Stem cells and development. 15(3)

Mesenchymal stem cells (MSCs) have demonstrated efficacy as cellular vectors for treating a variety of nervous system disorders. Nevertheless, few studies have quantified MSC engraftment levels or explored the mechanisms that promote their survival a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dbde5387a1c8f60bbd94c2394f37f5f
https://pubmed.ncbi.nlm.nih.gov/16846379

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Biological activities encoded by the murine mesenchymal stem cell transcriptome provide a basis for their developmental potential and broad therapeutic efficacy

Autor: Robin Wilkinson, Charles Michelson, Donald G. Phinney, Maria F. Dutreil, Erica Bayly, Catherine Hughes, Sally Humphries, Katy Hill, Melody Baddoo

Publikováno v: Stem cells (Dayton, Ohio). 24(1)

We used serial analysis of gene expression to catalog the transcriptome of murine mesenchymal stem cells (MSCs) enriched from bone marrow by immunodepletion. Interrogation of this database, results of which are delineated in the appended databases, r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dbb80c43b93f9edd64fbe7599b74c34
https://pubmed.ncbi.nlm.nih.gov/16100003

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