Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Maria Esperanza Rodriguez-Ruiz"'
Endoscopical and pathological dissociation in severe colitis induced by immune-checkpoint inhibitors
Autor:
Carlos Eduardo de Andrea, Jose Luis Perez-Gracia, Eduardo Castanon, Mariano Ponz-Sarvise, Jose I. Echeveste, Ignacio Melero, Miguel F. Sanmamed, Maria Esperanza Rodriguez-Ruiz
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
Checkpoint inhibitors have improved the survival of patients with advanced tumors and show a manageable toxicity profile. However, auto-immune colitis remains a relevant side effect, and combinations of anti-PD1/PDL1 and anti-CTLA-4 increase its inci
Externí odkaz:
https://doaj.org/article/08bc054ae8b442af9a259734225c3883
Autor:
Maria Esperanza Rodriguez-Ruiz, Aitziber Buqué, Michal Hensler, Jonathan Chen, Norma Bloy, Giulia Petroni, Ai Sato, Takahiro Yamazaki, Jitka Fucikova, Lorenzo Galluzzi
Publikováno v:
OncoImmunology, Vol 8, Iss 11 (2019)
Caspase 3 (CASP3) has a key role in the execution of apoptosis, and many cancer cells are believed to disable CASP3 as a mechanism of resistance to cytotoxic therapeutics. Alongside, CASP3 regulates stress-responsive immunomodulatory pathways, includ
Externí odkaz:
https://doaj.org/article/d5d155fc51d74b22b14d6a824e4ff118
Publikováno v:
OncoImmunology, Vol 8, Iss 11 (2019)
Caspases are known for their ability to precipitate apoptosis. Our findings indicate that accelerating the terminal inactivation of cells dying in response to radiation therapy limit their immunogenicity as a consequence of reduced type I interferon
Externí odkaz:
https://doaj.org/article/2d71e7a5474046659e407ad88d85df7a
Autor:
Tamara Tanos, Kevin Smart, Valentina Gambardella, Kristoffer Rohrberg, Michael Ong, Maria Esperanza Rodriguez Ruiz, Jean-Pascal Machiels, Miguel Fernández Sanmamed, Josep Tabernero, Anna Spreafico, Daniel Renouf, Stephen Luen, Rachel Galot, Bernard Doger, Emiliano Calvo, Aung Naing, Samira Curdt, Nicolas Staedler, Mike Flores, Enrique Gómez Alcaide, Chiahuey Ooi, Michael Hettich, Sebastian Dziadek, Yuying Xie, Gabriel Schnetzler, Theresa Kolben, Linxinyu Xu, Vaios Karanikas, Christophe Boetsch
Publikováno v:
Cancer Research. 83:CT176-CT176
INTRODUCTION: Activated Tregs in the tumor micro-environment are correlated with poor outcomes, and are considered as key players in tumor immune-escape. So far, Treg depletion has not been successful in patients, either because adequate Treg depleti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::217a7c59c9c441d0bb31a8fa513d8cd9
https://doi.org/10.1158/1538-7445.am2023-ct176
https://doi.org/10.1158/1538-7445.am2023-ct176
Autor:
Maria Esperanza, Rodriguez-Ruiz, Takahiro, Yamazaki, Aitziber, Buqué, Norma, Bloy, Viviane A O, Silva, Lena, Stafford, Ai, Sato, Lorenzo, Galluzzi
Publikováno v:
Methods in enzymology. 635
Focal radiation therapy has the potential to generate systemic tumor-targeting immune responses so potent as to eradicate anatomically distant, non-irradiated malignant lesions, a phenomenon commonly referred to as "the abscopal response." In cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::78d7325982a079fb143af5bfa49ac16b
https://pubmed.ncbi.nlm.nih.gov/32122540
https://pubmed.ncbi.nlm.nih.gov/32122540
Autor:
Maria Esperanza, Rodriguez-Ruiz, Ilio, Vitale, Kevin J, Harrington, Ignacio, Melero, Lorenzo, Galluzzi
Publikováno v:
Nature immunology. 21(2)
Therapeutic irradiation of the tumor microenvironment causes differential activation of pro-survival and pro-death pathways in malignant, stromal, endothelial and immune cells, hence causing a profound cellular and biological reconfiguration via mult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3999bff62606bf4261e8b58a8aa18713
https://pubmed.ncbi.nlm.nih.gov/31873291
https://pubmed.ncbi.nlm.nih.gov/31873291