Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Maria Erecińska"'
Publikováno v:
Journal of Neurochemistry. 66:2136-2145
The metabolism of branched-chain amino acids (BCAAs) was studied in cortical synaptosomes. With [15N]leucine (1 mM) as precursor, the cumulative appearance of 15N in [15N]glutamate and [15N]aspartate was 0.2 nmol/min/mg of protein without supplementa
Autor:
David Nelson, Maria Erecińska
Publikováno v:
Journal of Neurochemistry. 63:1033-1041
3-Nitropropionic acid (3-NPA) inhibited synaptosomal respiration in a dose-dependent manner; the degree of inhibition by the same concentration of the compound was greater, however, when respiration was stimulated by concomitant increase in ATP usage
Publikováno v:
Journal of Neurochemistry. 65:2765-2772
The effect of [H+] on the rate of glycolysis was investigated in glioma C6 and fibroblast BHK-21 cells and in synaptosomes from rat brain. The rates of lactate production at an extracellular pH (pHe) of 6.2, 7.4, and 7.8 were correlated with intracel
Publikováno v:
Journal of Neurochemistry. 63:751-757
Magnesium and the polyamines putrescine, spermidine, and spermine inhibited the activity of glutamate dehydrogenase in permeabilized rat brain mitochondria in a concentration-dependent manner. The inhibitory effect was observed on both the reductive
Publikováno v:
Journal of Neurochemistry. 65:2699-2705
The effects of nitroprusside and S-nitrosocysteine, compounds that generate nitric oxide (NO), on synaptosomal energy-producing pathways and energy level were investigated. The decrease in respiration was much faster and more pronounced with S-nitros
Publikováno v:
Journal of Neurochemistry. 67:2325-2334
Stable isotopes were used to measure both the rate of GABA formation by glutamic acid decarboxylase (GAD) and the rate of utilization by GABA-transaminase (GABA-T). The initial rate of GABA accumulation, determined with either [2-15N]glutamine or [2H
Publikováno v:
Neuroscience. 86:279-290
Several inhibitors of mitochondrial complex II cause neuronal death in vivo and in vitro. The goal of the present work was to characterize in vitro the effects of malonate (a competitive blocker of the complex) which induces neuronal death in a patte
Autor:
Ian A. Silver, Maria Erecińska
Publikováno v:
Journal of Neurophysiology. 79:1733-1745
Silver, Ian A. and Maria Erecińska. Glucose-induced intracellular ion changes in sugar-sensitive hypothalamic neurons. J. Neurophysiol. 79: 1733–1745, 1998. In the lateral hypothalamic area (LHA) of rat brain, ∼30% of cells showed sensitivity to
Autor:
Ian A. Silver, Maria Erecińska
Publikováno v:
Glia. 21:35-45
Cultured astrocytes and cell lines derived therefrom maintain a high energy level ([ATP]/[ADP]) through operation of oxidative phosphorylation and glycolysis. The contribution from the latter to total ATP production is 25–32%. A powerful Na+/K+ pum
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1277(1-2):13-34
R e v i e w Metabolic and energetic properties of isolated nerve ending particles (synaptosomes) Maria Erecifiska a, David Nelson b, Ian A. Si lver b,, Department of Pharmacology, UniL'ersity of Pennsyh,ania, School of Medicine, Philadelphia, PA 1910