Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Maria Elisa Lopes Pires"'
Autor:
Leandro Augusto Rosseto, Maria Elisa Lopes Pires, Aylime Castanho Bolognesi Melchior, Priscila Longhin Bosquesi, Aline Renata Pavan, Sisi Marcondes, Man Chin Chung, Jean Leandro dos Santos
Publikováno v:
Molecules, Vol 20, Iss 10, Pp 18185-18200 (2015)
Thrombosis is the main outcome of many cardiovascular diseases. Current treatments to prevent thrombotic events involve the long-term use of antiplatelet drugs. However, this therapy has several limitations, thereby justifying the development of new
Externí odkaz:
https://doaj.org/article/a2db657dc6bb4d2f83d64b2875ca34d9
Autor:
Thais Regina Ferreira de Melo, Rafael Consolin Chelucci, Maria Elisa Lopes Pires, Luiz Antonio Dutra, Karina Pereira Barbieri, Priscila Longhin Bosquesi, Gustavo Henrique Goulart Trossini, Man Chin Chung, Jean Leandro dos Santos
Publikováno v:
International Journal of Molecular Sciences, Vol 15, Iss 4, Pp 5821-5837 (2014)
A series of anti-inflammatory derivatives containing an N-acyl hydrazone subunit (4a–e) were synthesized and characterized. Docking studies were performed that suggest that compounds 4a–e bind to cyclooxygenase (COX)-1 and COX-2 isoforms, but wit
Externí odkaz:
https://doaj.org/article/d58cefcfc6fe415badc1ca4d8f450886
Autor:
Rafael Consolin Chelucci, Luiz Antônio Dutra, Maria Elisa Lopes Pires, Thais Regina Ferreira de Melo, Priscila Longhin Bosquesi, Man Chin Chung, Jean Leandro dos Santos
Publikováno v:
Molecules, Vol 19, Iss 2, Pp 2089-2099 (2014)
Nonsteroidal anti-inflammatory drugs (NSAIDs) 1–5 containing an N-acyl hydrazone subunit were prepared and their antiplatelet and antithrombotic activities assessed in vitro and in vivo. Compounds 1–5 inhibited the platelet aggregation induced by
Externí odkaz:
https://doaj.org/article/e94f9980cf8b4224ad5a42ffb4507e84
Autor:
Ana C. Antunes Naime, Pedro H. L. Bonfitto, Carolina Solon, Maria Elisa Lopes-Pires, Gabriel F. Anhê, Edson Antunes, Sisi Marcondes
Publikováno v:
Platelets, Vol 30, Iss 8, Pp 1047-1052 (2019)
Increased reactive oxygen species (ROS) production leads to tissue damage observed in sepsis and lipopolysaccharide (LPS)-exposed animals. LPS stimulates cytokines releasing, including tumor necrosis factor alpha (TNF-α), that is important to ROS pr
Externí odkaz:
https://doaj.org/article/65f934e5a45e4e67bdff7c9946b4b6cb
Autor:
Jane A. Mitchell, Maria Vinokurova, Maria Elisa Lopes-Pires, Fisnik Shala, Paul C. Armstrong, Blerina Ahmetaj-Shala, Youssef Elghazouli, Bin Liu, Yingbi Zhou, Chuan-ming Hao, Harvey R. Herschman, Nicholas S. Kirkby
Prostacyclin is one of the bodies fundamental signalling pathways. It has long been considered principally anti-thrombotic hormone derived from the vascular endothelium. The role of non-vascular sources in prostacyclin synthesis has not been systemat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddb6179cc0bf5e2e0fe4df7ebe73f8f2
https://doi.org/10.1101/2022.01.11.475814
https://doi.org/10.1101/2022.01.11.475814
Autor:
Isabela Junqueira Oliveira, Sisi Marcondes, Karina Pereira Barbieri, Iracilda Zeppone Carlos, Diego Eidy Chiba, ManChin Chung, Rafael Consolin Chelucci, Jean Leandro dos Santos, Maria Elisa Lopes-Pires, Marisa Campos Polesi
Publikováno v:
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Made available in DSpace on 2019-10-06T15:44:48Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-08-01 Sickle Cell Anemia (SCA) is one of the most prevalent hereditary hematological diseases worldwide. The disease is characterized by chronic in
Autor:
Andrew Ravendren, Joshua Benson, Rachel Y. Loy, Jane A. Mitchell, Anna Nicolaou, Maria Elisa Lopes Pires, Paula Urquhart, Nicholas S. Kirkby, Harvey R. Herschman, Fisnik Shala
Publikováno v:
Mitchell, J A, Shala, F, Pires, M E L, Loy, R Y, Ravendren, A, Benson, J, Urquhart, P, Nicolaou, A, Herschman, H R & Kirkby, N S 2021, ' Endothelial cyclooxygenase-1 paradoxically drives local vasoconstriction and atherogenesis despite underpinning prostacyclin generation ', Science Advances, vol. 7, no. 12, pp. eabf6054 . https://doi.org/10.1126/sciadv.abf6054
Science Advances
Science Advances
A paradoxical role for vascular COX-1 products in vasoconstriction and atherogenesis highlights it as a novel therapeutic target.
Endothelial cyclooxygenase-1–derived prostanoids, including prostacyclin, have clear cardioprotective roles assoc
Endothelial cyclooxygenase-1–derived prostanoids, including prostacyclin, have clear cardioprotective roles assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71146ff94e38589fc8e2b137fbd1913e
https://doi.org/10.1126/sciadv.abf6054
https://doi.org/10.1126/sciadv.abf6054
Publikováno v:
Antioxidants
Antioxidants, Vol 11, Iss 88, p 88 (2022)
Antioxidants, Vol 11, Iss 88, p 88 (2022)
Sepsis is regarded as one of the main causes of death among the critically ill. Pathogen infection results in a host-mediated pro-inflammatory response to fight infection; as part of this response, significant endogenous reactive oxygen (ROS) and nit
Autor:
Ricky Vaja, Plinio Ferreira, Timothy D. Warner, Paul C Armstrong, Nicholas S. Kirkby, Marilena Crescente, Maria Elisa Lopes Pires, Jane A. Mitchell, Blerina Ahmetaj-Shala
Publikováno v:
Pharmacology & Therapeutics. 217:107624
Cyclooxygenase (COX)-1 and COX-2 are centrally important enzymes within the cardiovascular system with a range of diverse, sometimes opposing, functions. Through the production of thromboxane, COX in platelets is a pro-thrombotic enzyme. By contrast,
Autor:
Konstantin Chegaev, Fernando Ferreira Costa, Chutima Kumkhaek, Ticiana Sidorenko de Oliveira Capote, Jean Leandro dos Santos, Roberta Fruttero, Thais Regina Ferreira de Melo, Man Chin Chung, Rafael Consolin Chelucci, Carolina Lanaro, Karina Pereira Barbieri, Iracilda Zeppone Carlos, Griffin P. Rodgers, Guilherme Felipe dos Santos Fernandes, Fernanda Coelho, Sisi Marcondes, Maria Elisa Lopes Pires, Stefano Guglielmo
Publikováno v:
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Made available in DSpace on 2018-12-11T17:37:51Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-06-25 N-oxide derivatives 5(a-b), 8(a-b), and 11(a-c) were designed, synthesized and evaluated in vitro and in vivo as potential drugs that are abl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa67192e62d6598f778912b5ba9c54e5