Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Maria Elida Scassa"'
Autor:
Victorio Martin Pozo Devoto, Nicolas Dimopoulos, Matías Alloatti, María Belén Pardi, Trinidad M. Saez, María Gabriela Otero, Lucas Eneas Cromberg, Antonia Marín-Burgin, Maria Elida Scassa, Gorazd B. Stokin, Alejandro F. Schinder, Gustavo Sevlever, Tomás Luis Falzone
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract The etiology of Parkinson’s disease (PD) converges on a common pathogenic pathway of mitochondrial defects in which α-Synuclein (αSyn) is thought to play a role. However, the mechanisms by which αSyn and its disease-associated allelic v
Externí odkaz:
https://doaj.org/article/ed7ab461035b478bbf2b97dcb519d281
Autor:
Leonardo Romorini, Diego Ariel Riva, Carolina Blüguermann, Guillermo Agustin Videla Richardson, Maria Elida Scassa, Gustavo Emilio Sevlever, Santiago Gabriel Miriuka
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e70267 (2013)
Human embryonic stem cells (hESCs) are self-renewing pluripotent cells that can differentiate into specialized cells and hold great promise as models for human development and disease studies, cell-replacement therapies, drug discovery and in vitro c
Externí odkaz:
https://doaj.org/article/5f09bfd164cd4ef5ab6a0ead1a83e637
Autor:
Sofía Mucci, Luciana Isaja, María Soledad Rodríguez-Varela, Sofía Luján Ferriol-Laffouillere, Mariela Marazita, Guillermo Agustín Videla-Richardson, Gustavo Emilio Sevlever, María Elida Scassa, Leonardo Romorini
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Human embryonic and induced pluripotent stem cells are self-renewing pluripotent stem cells (hPSCs) that can differentiate into a wide range of specialized cells. Although moderate hypoxia (5% O2) improves hPSC self-renewal, pluripotency, an
Externí odkaz:
https://doaj.org/article/75b0c55544d349ddb85d7eff7a9c2077
Autor:
Mariana Belén Vera, Olivia Morris-Hanon, Germán Ignacio Nogueiras, Luisina Belén Ripari, Myrian Inés Esquivel, Carolina Perez-Castro, Leonardo Romorini, Gustavo Emilio Sevlever, María Elida Scassa, Guillermo Agustín Videla-Richardson
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract The recurrence of Glioblastoma is partly attributed to the highly resistant subpopulation of glioma stem cells. A novel therapeutic approach focuses on restoring apoptotic programs in these cancer stem cells, as they are often deregulated. B
Externí odkaz:
https://doaj.org/article/b56cda3846f84834a6885829998d43e4
Autor:
Sofía Mucci, María Soledad Rodriguez-Varela, Luciana Isaja, Sofía Luján Ferriol-Laffouillere, Gustavo Emilio Sevlever, María Elida Scassa, Leonardo Romorini.
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101487- (2022)
Summary: The analysis of morphological features of neurons derived from human pluripotent stem cells (hPSCs) is important to describe neuronal phenotypes and changes observed throughout development. Using free and easily accessible tools, we describe
Externí odkaz:
https://doaj.org/article/76dc47c5474942cc8684d07ed8f3e3b0
Autor:
Luciana Isaja, María Soledad Rodríguez-Varela, Mariela Marazita, Sofía Mucci, Tatiana Itzcovich, Patricio Chrem-Méndez, Matías Niikado, Sofía Luján Ferriol-Laffouillere, Ricardo Allegri, Horacio Martinetto, Gustavo Emilio Sevlever, María Elida Scassa, Ezequiel Ignacio Surace, Leonardo Romorini
Publikováno v:
Stem Cell Research, Vol 53, Iss , Pp 102325- (2021)
Human induced pluripotent stem cells (hiPSC) line FLENIi001-A was reprogrammed from dermal fibroblasts using the lentiviral-hSTEMCCA-loxP vector. Fibroblasts were obtained from a skin biopsy of a 72-year-old Caucasian male familial Alzheimer's diseas
Externí odkaz:
https://doaj.org/article/7dd576c3b93e43cea246340cc5feb843
Autor:
Olivia Morris-Hanon, Verónica Alejandra Furmento, María Soledad Rodríguez-Varela, Sofía Mucci, Damián Darío Fernandez-Espinosa, Leonardo Romorini, Gustavo Emilio Sevlever, María Elida Scassa, Guillermo Agustín Videla-Richardson
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 19, Iss 7, Pp 519-529 (2017)
High-grade gliomas are the most prevalent and lethal primary brain tumors. They display a hierarchical arrangement with a population of self-renewing and highly tumorigenic cells called cancer stem cells. These cells are thought to be responsible for
Externí odkaz:
https://doaj.org/article/db28de4aee3b4039a69ec8627172e4b7
Autor:
María Questa, Leonardo Romorini, Carolina Blüguermann, Claudia María Solari, Gabriel Neiman, Carlos Luzzani, María Élida Scassa, Gustavo Emilio Sevlever, Alejandra Sonia Guberman, Santiago Gabriel Miriuka
Publikováno v:
Stem Cell Research, Vol 16, Iss 2, Pp 300-303 (2016)
Human foreskin fibroblasts were used to generate the iPSC line iPSC-FH2.1 using the EF1a-hSTEMCCA-loxP vector expressing OCT4, SOX2, c-MYC and KLF4, in 5% O2 culture conditions. Stemness was confirmed, as was pluripotency both in vivo and in vitro, i
Externí odkaz:
https://doaj.org/article/30607d771dbc4c7099d923c5f9fedae8
Topoisomerase I inhibitor, camptothecin, induces apoptogenic signaling in human embryonic stem cells
Autor:
Carolina Paola García, Guillermo Agustín Videla Richardson, Leonardo Romorini, Santiago Gabriel Miriuka, Gustavo Emilio Sevlever, María Elida Scassa
Publikováno v:
Stem Cell Research, Vol 12, Iss 2, Pp 400-414 (2014)
Embryonic stem cells (ESCs) need to maintain their genomic integrity in response to DNA damage to safeguard the integrity of the organism. DNA double strand breaks (DSBs) are one of the most lethal forms of DNA damage and, if not repaired correctly,
Externí odkaz:
https://doaj.org/article/8ffc0d1bb9724fe9b34607b07966dee2
Autor:
Carolina Paola García, Guillermo Agustín Videla Richardson, Nicolás Alexis Dimopoulos, Damián Darío Fernandez Espinosa, Santiago Gabriel Miriuka, Gustavo Emilio Sevlever, Leonardo Romorini, María Elida Scassa
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0152607 (2016)
Human embryonic stem cells (hESCs) are hypersensitive to genotoxic stress and display lower survival ability relative to their differentiated progeny. Herein, we attempted to investigate the source of this difference by comparing the DNA damage respo
Externí odkaz:
https://doaj.org/article/0ba60848e2e24758a8096beabbf0f353