Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Maria Ejlersen"'
1
Modification of oligodeoxynucleotides by on-column Suzuki cross-coupling reactions
Autor: Yogesh S. Sanghvi, Maria Ejlersen, Chenguang Lou, Yitzhak Tor, Jesper Wengel
Publikováno v: Ejlersen, M, Lou, C, Sanghvi, Y S, Tor, Y & Wengel, J 2018, ' Modification of oligodeoxynucleotides by on-column Suzuki cross-coupling reactions ', Chemical Communications, vol. 54, no. 57, pp. 8003-8006 . https://doi.org/10.1039/c8cc01360h
The on-column functionalization of oligodeoxynucleotides via base-free Suzuki cross-coupling reactions is reported herein. These cross-coupling reactions were carried out with various boronic acids and either full-length modified oligonucleotides con
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd34cf39df5473c88ede221c3b95bc68
https://doi.org/10.1039/c8cc01360h
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2
3′-Pyrene-modified unlocked nucleic acids: synthesis, fluorescence properties and a surprising stabilization effect on duplexes and triplexes
Autor: Maria Ejlersen, Niels Langkjær, Jesper Wengel
Publikováno v: Ejlersen, M, Langkjær, N & Wengel, J 2017, ' 3'-Pyrene-modified unlocked nucleic acids : synthesis, fluorescence properties and a surprising stabilization effect on duplexes and triplexes ', Organic & Biomolecular Chemistry, vol. 15, no. 9, pp. 2073-2085 . https://doi.org/10.1039/c6ob02773c
Efficient synthesis of a new 3'-O-amino-UNA monomer was developed as a scaffold for further functionalization and incorporation into oligonucleotides (ONs). Pyrene-functionalized 3'-O-amino-UNA was incorporated one, two or three times into 21-mer DNA
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfdc8060a6e476e5f030dcee4c815943
https://doi.org/10.1039/c6ob02773c
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3
Synergy of Two Highly Specific Biomolecular Recognition Events:Aligning an AT-Hook Peptide in DNA Minor Grooves via Covalent Conjugation to 2'-Amino-LNA
Autor: Chenguang Lou, Knud J. Jensen, Niels Johan Christensen, Jesper Wengel, Kasper K. Sørensen, Maria Ejlersen
Publikováno v: Ejlersen, M, Christensen, N J, Sørensen, K K, Jensen, K J, Wengel, J & Lou, C 2018, ' Synergy of Two Highly Specific Biomolecular Recognition Events : Aligning an AT-Hook Peptide in DNA Minor Grooves via Covalent Conjugation to 2'-Amino-LNA ', Bioconjugate Chemistry, vol. 29, no. 4, pp. 1025–1029 . https://doi.org/10.1021/acs.bioconjchem.8b00101
Two highly specific biomolecular recognition events, nucleic acid duplex hybridization and DNA-peptide recognition in the minor groove, were coalesced in a miniature ensemble for the first time by covalently attaching a natural AT-hook peptide motif
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5abf1193ad810de17897f41cd5ff4db
https://findresearcher.sdu.dk:8443/ws/files/137708443/Synergy_of_two_highly_specific_biomolecular_recognition_events_aligning_an_AT_hook_peptide_in_DNA_minor_grooves_via_covalent_conjugation_to_2_amino_LNA.pdf
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4
Folding Topology of a Short Coiled-Coil Peptide Structure Templated by an Oligonucleotide Triplex
Autor: Chenguang Lou, Knud J. Jensen, Niels Johan Christensen, Peter W. Thulstrup, Jesper Wengel, Søren Roi Midtgaard, Kasper K. Sørensen, Manuel C. Martos-Maldonado, Maria Ejlersen
Publikováno v: Lou, C, Christensen, N J, Martos-Maldonado, M C, Midtgaard, S R, Ejlersen, M, Thulstrup, P W, Sørensen, K K, Jensen, K J & Wengel, J 2017, ' Folding Topology of a Short Coiled-Coil Peptide Structure Templated by an Oligonucleotide Triplex ', Chemistry: A European Journal, vol. 23, no. 39, pp. 9297–9305 . https://doi.org/10.1002/chem.201700971
The rational design of a well-defined protein-like tertiary structure formed by small peptide building blocks is still a formidable challenge. By using peptide-oligonucleotide conjugates (POC) as building blocks, we present the self-assembly of minia
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0926feacd7f52c63ebb8351c12a336a0
https://findresearcher.sdu.dk:8443/ws/files/128491831/Accepted_manuscript_of_Folding_Topology_of_a_Short_Coiled_Coil_Peptide_Structure.pdf
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6
Bis-pyrene-modified unlocked nucleic acids: synthesis, hybridization studies, and fluorescent properties
Autor: Niels Langkjær, Jesper Wengel, Pavla Perlíková, Maria Ejlersen
Publikováno v: Perlíková, P, Ejlersen, M, Langkjaer, N & Wengel, J 2014, ' Bis-pyrene-modified unlocked nucleic acids: synthesis, hybridization studies, and fluorescent properties ', ChemMedChem, vol. 9, no. 9, pp. 2120-2127 . https://doi.org/10.1002/cmdc.201402185
Efficient synthesis of a building block for the incorporation of a bis-pyrene-modified unlocked nucleic acid (UNA) into oligonucleotides (DNA*) was developed. The presence of bis-pyrene-modified UNA within a duplex leads to duplex destabilization tha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e9144e51ea076a8054ed9218bbc7e90
https://portal.findresearcher.sdu.dk/da/publications/81b210f3-6487-4c12-8fd0-33316fcc10c3
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