Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Maria E. Trujillo"'
Autor:
Sebastian Frechen, Ibrahim Ince, André Dallmann, Michael Gerisch, Natalia A. Jungmann, Corina Becker, Maximilian Lobmeyer, Maria E. Trujillo, Shiyao Xu, Rolf Burghaus, Michaela Meyer
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 1, Pp 79-92 (2024)
Abstract Vericiguat (Verquvo; US: Merck, other countries: Bayer) is a novel drug for the treatment of chronic heart failure. Preclinical studies have demonstrated that the primary route of metabolism for vericiguat is glucuronidation, mainly catalyze
Externí odkaz:
https://doaj.org/article/c66c5343a35c4c0781974a7a44021a40
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 12, Pp 2458-2466 (2023)
Abstract Vericiguat, a novel soluble guanylate cyclase (sGC) stimulator, is approved for the treatment of heart failure (HF) with reduced ejection fraction (HFrEF). Decreased nitric oxide (NO) availability, sGC desensitization to NO, sGC deficiency,
Externí odkaz:
https://doaj.org/article/42cd961c15134974a140a250703dd13e
Autor:
Alexis Jose-Abrego, Maria E. Trujillo-Trujillo, Saul Laguna-Meraz, Sonia Roman, Arturo Panduro
Publikováno v:
Pathogens, Vol 13, Iss 5, p 360 (2024)
The complex epidemiology of hepatitis C virus (HCV) infection among human immunodeficiency virus (HIV) patients in West Mexico remains poorly understood. Thus, this study aimed to investigate the HCV prevalence, HCV-associated risk factors, and HCV g
Externí odkaz:
https://doaj.org/article/f2bd25a4388549958e2a0e38851deac3
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 6, Pp 356-358 (2019)
Externí odkaz:
https://doaj.org/article/cd476d32487948f99dd78f2111a33827
Autor:
Linda E. Muñoz-Espinosa, Maria E. Trujillo-Trujillo, Roberto F. Martínez-Macías, Arturo Panduro, Ana M. Rivas-Estilla, Nora A. Fierro, Ana L. Silvera-Linares, Rafael Torres-Valadez, Paula Cordero-Pérez, Karina González-Aldaco, Carlos Y. Chen-López, Alexis José-Abrego, Jaime R. Zuñiga-Noriega, Maria C. Gutiérrez-Ruiz, Sonia Roman, Ph.D.
Publikováno v:
Annals of Hepatology, Vol 14, Iss 5, Pp 642-651 (2015)
Background. The evolving pattern of HCV genotypes (GTs) and risk factors (RFs) in HCV-infected patients in Mexico is poorly understood. This study aimed to access the temporal trend of HCV GTs and RFs in HCV patients from two care centers.Material an
Externí odkaz:
https://doaj.org/article/daa5f95b24f24115989856f8717f501a
Autor:
Maria E. Trujillo, Leticia Arrington, Yogesh Patel, Julie Passarell, Larissa Wenning, Robert O. Blaustein, Paul W. Armstrong, Michaela Meyer, Corina Becker, Ferdous Gheyas
Publikováno v:
Clinical pharmacology and therapeutics. 112(5)
Vericiguat, a novel stimulator of soluble guanylate cyclase (sGC), is indicated for the treatment of patients following a hospitalization for heart failure or need for outpatient intravenous diuretics, with symptomatic chronic heart failure and eject
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba0a128a8d3c49fa41995bf0e94a261b
https://pubmed.ncbi.nlm.nih.gov/35841202
https://pubmed.ncbi.nlm.nih.gov/35841202
Autor:
Barbara Pio, Ravi P. Nargund, Yan Guo, Daniel Kosinski, Josien Hubert B, Michael Wright, Michele Pachanski, Harry R. Chobanian, Xiaoping Zhang, Richard Tschirret-Guth, Melissa Kirkland, Andrew D. Howard, Sarah Souza, Eric R. Ashley, Robert K. Orr, Steven L. Colletti, Joel Mane, Jerry Di Salvo, Michael W. Miller, Boonlert Cheewatrakoolpong, Koppara Samuel, William K. Hagmann, James Lamca, Juliann Ehrhart, Maria E. Trujillo, Jackie Shang, Qing Chen, Adam B. Weinglass, Randal M. Bugianesi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:1842-1848
GPR40 (FFAR1 or FFA1) is a G protein-coupled receptor, primarily expressed in pancreatic islet β-cells and intestinal enteroendocrine cells. When activated by fatty acids, GPR40 elicits increased insulin secretion from islet β-cells only in the pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67130fd906c302e54806df711af08d1b
https://doi.org/10.1016/j.bmcl.2019.04.050
https://doi.org/10.1016/j.bmcl.2019.04.050
Autor:
F. Anthony Romero, Robert W. Myers, Hong-Ping Guan, Anantha Gollapudi, Gaochao Zhou, Ku Lu, James F. Dropinski, Marc M. Kurtz, Xiaodong Yang, Cai Li, Iyassu K. Sebhat, Tesfaye Biftu, Danqing Feng, Ahmet Kekec, Ann E. Weber, Qing Shao, Daniel M. Kemp, Andrew Kassick, Shiyao Xu, Maria E. Trujillo
Publikováno v:
ACS Medicinal Chemistry Letters. 9:39-44
5'-Adenosine monophosphate-activated protein kinase (AMPK) is a key regulator of mammalian energy homeostasis and has been implicated in mediating many of the beneficial effects of exercise and weight loss including lipid and glucose trafficking. As
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::523ed2d42da00835ac297ba9e01c4ffe
https://doi.org/10.1021/acsmedchemlett.7b00417
https://doi.org/10.1021/acsmedchemlett.7b00417
Autor:
Judith N. Gorski, Maria E. Trujillo, Brande Thomas-Fowlkes, Adam B. Weinglass, Jerry Di Salvo, Aimie M. Ogawa, Sarah Souza, Christopher W. Plummer, Joel Mane, Michele Pachanski, Boonlert Cheewatrakoolpong, Andrew D. Howard, Steven L. Colletti
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 313:E37-E47
G protein-coupled receptor 40 (GPR40) partial agonists lower glucose through the potentiation of glucose-stimulated insulin secretion, which is believed to provide significant glucose lowering without the weight gain or hypoglycemic risk associated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc4daac847ef7e96602196782cbdb63
https://doi.org/10.1152/ajpendo.00435.2016
https://doi.org/10.1152/ajpendo.00435.2016
Autor:
Bei Zhang, Jiayi Xu, Robert W. Myers, Roman Kats-Kagan, Qinghong Fu, Sunita Malkani, Hsuan-shen Chen, Rui Zhang, Maria E. Trujillo, Michael Kavana, Daniel R. McMasters, Brian T. Campbell, George H. Addona, George J. Eiermann, Zhesheng Chen, Michele Pachanski, Fengqi Zhang, Brian T. Farrer, Kaushik Mitra, Libo Xu, Nadine Elowe, Joel P. Berger, Emma R. Parmee, Songnian Lin, Wen Feng, Xinchun Tong
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:2069-2073
Glucokinase (GK, hexokinase IV) is a unique hexokinase that plays a central role in mammalian glucose homeostasis. Glucose phosphorylation by GK in the pancreatic β-cell is the rate-limiting step that controls glucose-stimulated insulin secretion. S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f297c94aef86ac210547893541fab565
https://doi.org/10.1016/j.bmcl.2016.10.085
https://doi.org/10.1016/j.bmcl.2016.10.085