Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Maria E. Baca-Estrada"'
Publikováno v:
Canadian Journal of Gastroenterology, Vol 10, Iss 2, Pp 110-114 (1996)
The diversity of the T cell receptor repertoire is generated through rearrangement of the variable, junctional and constant region genes. Selection processes in the thymus and periphery serve to eliminate self-reacting T cells, thereby preventing aut
Externí odkaz:
https://doaj.org/article/21cf3f7ea24341c0bfae9ae3060e02df
Autor:
Rolf Hecker, Praveen Kumar, Maria E. Baca-Estrada, V L Alcón, M. A. Vega-Lopez, Lorne A. Babiuk, Marianna Foldvari, Philip Willson
Publikováno v:
The AAPS Journal. 7:E566-E571
The ineffectiveness of simple delivery of soluble antigens to mucosal membranes for immunization has stimulated extensive studies of strategies for appropriate delivery systems and adjuvants. Biphasic lipid vesicles are formulations suitable for the
Autor:
Lorne A. Babiuk, M. A. Vega-Lopez, V L Alcón, Philip Willson, Praveen Kumar, Maria E. Baca-Estrada, Marianna Foldvari
Publikováno v:
Journal of Pharmacy and Pharmacology. 57:955-961
The nasal mucosa is an important arm of the mucosal system since it is often the first point of contact for inhaled antigens. The ineffectiveness of the simple delivery of soluble antigens to mucosal membranes for immunization has stimulated extensiv
Autor:
Lorne A. Babiuk, Georg Widera, Shawn Babiuk, Dorothy M. Middleton, Maria E. Baca-Estrada, Deitmar Rabussay, Marianna Foldvari
Publikováno v:
Journal of Biotechnology. 110:1-10
One potential reason for the enhancement of immune responses to DNA vaccines following electroporation is increased gene expression. However, the inflammatory response and accompanying cellular infiltration stimulated by electroporation may also be e
Autor:
Dorothy M. Middleton, Lorne A. Babiuk, Rolf Hecker, Maria E. Baca-Estrada, Shawn Babiuk, Marianna Foldvari
Publikováno v:
Current Drug Delivery. 1:9-15
CpG oligonucleotides (ODNs) are potent mucosal and systemic adjuvants. For practical applications however, improvements in delivery need to be developed. A mouse model was used to determine if the biological activity of CpG ODNs could be enhanced usi
Autor:
Georg Widera, Marianna Foldvari, Lawrence Baizer, Maria E. Baca-Estrada, Michael Storms, Dietmar Rabussay, Richard Stout, Shawn Babiuk, Lorne A. Babiuk
Publikováno v:
Molecular Therapy. 8:992-998
Electroporation has been shown to increase the potency of DNA vaccines that have demonstrated significant potential in mice. However, there is a need to develop noninvasive or minimally invasive vaccination methods. In pigs, in vivo gene expression w
Autor:
Maria E. Baca-Estrada, Catherine Ewen
Publikováno v:
Journal of Interferon & Cytokine Research. 21:39-43
The ability to accurately measure cytokine secretion by immune cells is critical to the evaluation of immune mechanisms in the context of Th1 and Th2 responses. In this study, we demonstrated that in vitro consumption of interleukin-4 (IL-4) by stimu
Publikováno v:
Vaccine. 18:1847-1854
The development of non-invasive methods for the delivery of proteins through the permeability barriers, such as the intact skin, will greatly facilitate the administration of human and veterinary vaccines. In the present study we used recombinant Pas
Autor:
John R. Gordon, Zsuzsanna Papp, Dorothy M. Middleton, Maria E. Baca-Estrada, Marianna Foldvari, Christine M. Rontved
Publikováno v:
Journal of Interferon & Cytokine Research. 20:191-196
Although the roles of interleukin-12 (IL-12) in the immunomodulation of antigen-specific responses are well characterized, the effects of IL-12 on the respiratory tract following mucosal administration are not well defined. Therefore, we investigated
Autor:
Jeff Lewis, Maria E. Baca-Estrada, Lorne A Babiuk, Shawn Babiuk, Marianna Foldvari, Sanipa Suradhat
Publikováno v:
Journal of Biotechnology. 73:131-140
Polynucleotide immunization has been described as the Third Revolution in Vaccinology. Early studies suggest the potential benefits of this form of immunization including: long-lived immunity, a broad-spectrum of immune responses (both cell mediated