Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Maria E Falzone"'
Autor:
Maria E. Falzone, Zhang Feng, Omar E. Alvarenga, Yangang Pan, ByoungCheol Lee, Xiaolu Cheng, Eva Fortea, Simon Scheuring, Alessio Accardi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Lipid scrambling is required for many cellular processes but the lipid-protein interactions that occur during transport are unknown. Using cryoEM and biochemical assays the authors show that membrane thinning is critical for lipid flipping.
Externí odkaz:
https://doaj.org/article/eb89ec895ead4ea1bd22a27cf17cce5f
Autor:
George Khelashvili, Maria E. Falzone, Xiaolu Cheng, Byoung-Cheol Lee, Alessio Accardi, Harel Weinstein
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
A membrane-exposed groove in Ca2+-gated TMEM16 scramblases forms the translocation pathway for ions and lipids. Here authors combine molecular dynamics with cryo-EM and functional assays to uncover the conformational transitions of the groove leading
Externí odkaz:
https://doaj.org/article/217f3e9521bd47ab84603e12a70c94d1
Autor:
Simon R. Bushell, Ashley C. W. Pike, Maria E. Falzone, Nils J. G. Rorsman, Chau M. Ta, Robin A. Corey, Thomas D. Newport, John C. Christianson, Lara F. Scofano, Chitra A. Shintre, Annamaria Tessitore, Amy Chu, Qinrui Wang, Leela Shrestha, Shubhashish M. M. Mukhopadhyay, James D. Love, Nicola A. Burgess-Brown, Rebecca Sitsapesan, Phillip J. Stansfeld, Juha T. Huiskonen, Paolo Tammaro, Alessio Accardi, Elisabeth P. Carpenter
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
TMEM16K is a member of the TMEM16 family of integral membrane proteins that are either lipid scramblases or chloride channels. Here the authors combine cell biology, electrophysiology measurements, X-ray crystallography, cryo-EM and MD simulations to
Externí odkaz:
https://doaj.org/article/602dd2cc133c49529d8807b7b0d875ca
Autor:
Maria E Falzone, Jan Rheinberger, Byoung-Cheol Lee, Thasin Peyear, Linda Sasset, Ashleigh M Raczkowski, Edward T Eng, Annarita Di Lorenzo, Olaf S Andersen, Crina M Nimigean, Alessio Accardi
Publikováno v:
eLife, Vol 8 (2019)
The lipid distribution of plasma membranes of eukaryotic cells is asymmetric and phospholipid scramblases disrupt this asymmetry by mediating the rapid, nonselective transport of lipids down their concentration gradients. As a result, phosphatidylser
Externí odkaz:
https://doaj.org/article/d8de76d559d7421aaf3e8ebaa4d6e9a6
Autor:
Maria E. Falzone, Roderick MacKinnon
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Phospholipase C-βs (PLCβs) catalyze the hydrolysis of phosphatidylinositol 4, 5–bisphosphate ( P I P 2 ) into inositoltriphosphate ( IP3 ) and diacylglycerol ( DAG ) . P I P 2 regulates the activity of many membrane proteins, while IP3 and DAG le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40a1ee106471c8d9cba31acf2f4ba83e
https://doi.org/10.1073/pnas.2301121120
https://doi.org/10.1073/pnas.2301121120
Autor:
Maria E. Falzone, Roderick MacKinnon
SummaryPLCβscatalyze the hydrolysis ofPIP2 into IP3 and DAG.PIP2 regulates the activity of many membrane proteins, while IP3 and DAG lead to increased intracellular Ca2+levels and activate PKC, respectively.PLCβsare regulated by GPCRs through direc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e168c198a5731262d77c1c40a85240b
https://doi.org/10.1101/2022.12.20.521270
https://doi.org/10.1101/2022.12.20.521270
Autor:
Elizabeth D. Kim, Maria E. Falzone, Gareth R. Tibbs, Matthew Ferrer, Peter A. Goldstein, Crina M. Nimigean
Publikováno v:
Biophysical Journal. 122:519a-520a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d699c428de8c5cb8cc8fe49d753eca53
https://doi.org/10.1016/j.bpj.2022.11.2761
https://doi.org/10.1016/j.bpj.2022.11.2761
Autor:
Maria E, Falzone, Jan, Rheinberger, Byoung-Cheol, Lee, Thasin, Peyear, Linda, Sasset, Ashleigh M, Raczkowski, Edward T, Eng, Annarita, Di Lorenzo, Olaf S, Andersen, Crina M, Nimigean, Alessio, Accardi
Publikováno v:
eLife
The lipid distribution of plasma membranes of eukaryotic cells is asymmetric and phospholipid scramblases disrupt this asymmetry by mediating the rapid, nonselective transport of lipids down their concentration gradients. As a result, phosphatidylser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ce980ba41e969c754a125175e14447c6
https://pubmed.ncbi.nlm.nih.gov/30648972
https://pubmed.ncbi.nlm.nih.gov/30648972
Autor:
Falzone, Maria E., Feng, Zhang, Alvarenga, Omar E., Pan, Yangang, Lee, ByoungCheol, Cheng, Xiaolu, Fortea, Eva, Scheuring, Simon, Accardi, Alessio
Publikováno v:
Nature Communications; 5/11/2022, Vol. 13 Issue 1, p1-14, 14p
Publikováno v:
Genomics & Genetics Weekly; 2024, p1808-1808, 1p