SCN5A mutations in Brugada syndrome are associated with increased cardiac dimensions and reduced contractility.

Autor: Frans van Hoorn, Maria E Campian, Anje Spijkerboer, Marieke T Blom, R Nils Planken, Albert C van Rossum, Jacques M T de Bakker, Arthur A M Wilde, Maarten Groenink, Hanno L Tan

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e42037 (2012)

BACKGROUND: The cardiac sodium channel (Na(v)1.5) controls cardiac excitability. Accordingly, SCN5A mutations that result in loss-of-function of Na(v)1.5 are associated with various inherited arrhythmia syndromes that revolve around reduced cardiac e

Externí odkaz: https://doaj.org/article/95a4fc16eb9a4957804670757c04603b

Right Ventricular Failure Following Chronic Pressure Overload Is Associated With Reduction in Left Ventricular Mass

Autor: Berto J. Bouma, Paul Bresser, Maxim Hardziyenka, Maarten Groenink, Christine A. Klemens, Hanno L. Tan, Maria E. Campian, Sulaiman Surie, Leander Beekman, Herre J. Reesink, Carol Ann Remme

Publikováno v: Journal of the American College of Cardiology. 57:921-928

Objectives We sought to study whether patients with right ventricular failure (RVF) secondary to chronic thromboembolic pulmonary hypertension (CTEPH) have reduced left ventricular (LV) mass, and whether LV mass reduction is caused by atrophy. Backgr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c4a413e885b2ca03abe605cab8aa0b
https://doi.org/10.1016/j.jacc.2010.08.648

Assessment of inflammation in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia

Autor: Maria E. Campian, Hein J. Verberne, Hanno L. Tan, Astrid F. van Moerkerken, Maxim Hardziyenka, Berthe L. F. van Eck-Smit, Elisabeth A. A. de Groot

Publikováno v: European Journal of Nuclear Medicine and Molecular Imaging
European journal of nuclear medicine and molecular imaging, 37(11), 2079-2085. Springer Verlag
European Journal of Nuclear Medicine and Molecular Imaging, 37(11), 2079-2085. Springer Verlag

Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is a myocardial disease that predominantly affects the right ventricle (RV). Its hallmark feature is fibro-fatty replacement of RV myocardium. However, patchy inflammatory infiltrates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::104f1eeb780450069ff0a35ebf37b881
https://doi.org/10.1007/s00259-010-1525-y

Nodoventricular Accessory Pathways in PRKAG2 -Dependent Familial Preexcitation Syndrome Reveal a Disorder in Cardiac Development

Autor: Henk J. Oskam, Anton E. Becker, Hanno L. Tan, Bram ten Hove Jansen, Dirk-Jan van Doorn, Arthur A.M. Wilde, Maria E. Campian, Hittjo H. Kruyswijk, Allard C. van der Wal

Publikováno v: Circulation. Arrhythmia and electrophysiology, 1(4), 276-281. Lippincott Williams and Wilkins

Background— Familial preexcitation syndrome is linked to mutations in PRKAG2 . Previous studies on the R302Q mutation have provided evidence for a remarkably high proportion of otherwise rare accessory pathways with atrioventricular (AV) node-like

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd62bfc5df18100fd1c1b1830e609837
https://doi.org/10.1161/circep.108.782862

SCN5A Mutations in Brugada Syndrome Are Associated with Increased Cardiac Dimensions and Reduced Contractility

Autor: Hanno L. Tan, Albert C. van Rossum, Frans van Hoorn, Anje M. Spijkerboer, Jacques M.T. de Bakker, Maarten Groenink, Marieke T. Blom, Arthur A.M. Wilde, R. Nils Planken, Maria E. Campian

Publikováno v: PLoS ONE, 7(8). Public Library of Science
PLoS ONE, 7(8):e42037. Public Library of Science
PLoS ONE, Vol 7, Iss 8, p e42037 (2012)
PLoS ONE
van Hoorn, F, Campian, M E, Spijkerboer, A, Blom, M T, Planken, R N, van Rossum, A C, de Bakker, J M T, Wilde, A A M, Groenink, M & Tan, H L 2012, ' Scn5a mutations in brugada syndrome are associated with increased cardiac dimensions and reduced contractility ', PLoS ONE, vol. 7, no. 8, e42037 . https://doi.org/10.1371/journal.pone.0042037

Background: The cardiac sodium channel (Nav1.5) controls cardiac excitability. Accordingly, SCN5A mutations that result in loss-of-function of Nav1.5 are associated with various inherited arrhythmia syndromes that revolve around reduced cardiac excit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5362661365d11cfac3bcb7faca70a029
https://pure.amc.nl/en/publications/scn5a-mutations-in-brugada-syndrome-are-associated-with-increased-cardiac-dimensions-and-reduced-contractility(c7492013-5b64-4099-a555-38afb080f394).html