Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Maria De Jesus Perry"'
Autor:
Joana Gonçalves, Joana D. Amaral, Rita Capela, Maria de Jesus Perry, Cláudia Braga, Maria Manuela Gaspar, Fátima M. Piedade, Lubertus Bijlsma, Antoni Roig, Sandra N. Pinto, Rui Moreira, Pedro Florindo, Cecília M. P. Rodrigues
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract Inducing necroptosis in cancer cells has emerged as an effective strategy to overcome drug resistance. However, while organic small molecules have been extensively studied for this purpose, metal-based compounds have received relatively litt
Externí odkaz:
https://doaj.org/article/cfb9a99efa384c4998ddab96fc03402d
Autor:
Katarzyna Błaszczak-Świątkiewicz, Diogo Correia Almeida, Maria De Jesus Perry, Elżbieta Mikiciuk-Olasik
Publikováno v:
Molecules, Vol 19, Iss 1, Pp 400-413 (2013)
In this work, a sensitive analytical method to study the stability of two new series of synthesized heterocyclic compounds, the benzimidazole-4,7-diones 5 and N-oxide benzimidazole-4,7-dione derivatives 6 was established and validated. These derivati
Externí odkaz:
https://doaj.org/article/77cb9cd851e643fc8563ed36726fdfb2
Autor:
Maria Manuela Gaspar, Jacinta O. Pinho, Eduarda Mendes, Ana Paula Francisco, Sofia G. Serra, Catarina Teixeira António, Maria João Penetra, Maria de Jesus Perry, Margarida Granada
Publikováno v:
ACS Med Chem Lett
[Image: see text] Malignant melanoma is the major cause of death from skin cancer. Treatment of metastatic melanoma remains an enormous challenge. In this study we developed hybrid compounds and studied their potential use in malignant melanoma chemo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca5f6ef435edac152dd5ba4eba7f9bb1
https://doi.org/10.1021/acsmedchemlett.1c00252
https://doi.org/10.1021/acsmedchemlett.1c00252
Publikováno v:
Current Pharmaceutical Design. 25:1623-1642
Triazenes are a very useful and diverse class of compounds that have been studied for their potential in the treatment of many tumors including brain tumor, leukemia and melanoma. Novel compounds of this class continue to be developed as either antic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92c392a4d559d320d39b42a609220f98
https://doi.org/10.2174/1381612825666190617155749
https://doi.org/10.2174/1381612825666190617155749
Autor:
Mónica S. Estevão, Rita G. Pereira, Maria B. T. Ferreira, Maria Manuela Gaspar, Catarina A. B. Rodrigues, Maria de Jesus Perry, Sara R. Oliveira, Joana D. Amaral, Rui Moreira, Pedro A. Dionísio, Carlos A. M. Afonso, Cecília M. P. Rodrigues
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 10
International Journal of Molecular Sciences, Vol 22, Iss 5289, p 5289 (2021)
Volume 22
Issue 10
International Journal of Molecular Sciences, Vol 22, Iss 5289, p 5289 (2021)
Parkinson’s disease (PD) is the second most common neurodegenerative disorder, mainly characterized by motor deficits correlated with progressive dopaminergic neuronal loss in the substantia nigra pars compacta (SN). Necroptosis is a caspase-indepe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b8650cca35531dd952ba169693839b8
https://pubmed.ncbi.nlm.nih.gov/34069782
https://pubmed.ncbi.nlm.nih.gov/34069782
Autor:
Maria Rosário Bronze, Sara Henriques, Pedro Florindo, Gustavo da Silva, Rui Moreira, Cristina de Mello-Sampayo, Joana Carrola, Catarina Correia, Noélia Duarte, Maria de Jesus Perry, Lubertus Bijlsma, Alvaro Lopes
Publikováno v:
Repositori Universitat Jaume I
Universitat Jaume I
Universitat Jaume I
N-ethylhexedrone (NEH) and buphedrone (BUPH) are synthetic drugs structurally related to natural cathinone. These synthetic cathinones (SC) are members of the heterogenous family of new psychoactive substances (NPS), which have caused major concern i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b795de3b29c704ca4804403348d296c6
Autor:
Daniela Miranda, Francisca Lopes, Inês S. Albuquerque, Rui Moreira, Margarida Sanches-Vaz, Marta Machado, Moni Sharma, Maria de Jesus Perry, Joana Magalhães, Miguel Prudêncio, Philip J. Rosenthal, Rita Capela, Raquel F. M. Frade, Jiri Gut
Publikováno v:
European Journal of Medicinal Chemistry
Hybrid compounds may play a critical role in the context of the malaria eradication agenda, which will benefit from therapeutic tools active against the symptomatic erythrocytic stage of Plasmodium infection, and also capable of eliminating liver sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18917fd79c320b8c1859cb9d56371cde
https://doi.org/10.1016/j.ejmech.2018.02.048
https://doi.org/10.1016/j.ejmech.2018.02.048
Autor:
M. Conceição Oliveira, M. Matilde Marques, Maria de Jesus Perry, Rui Moreira, Dora Brites, Cláudia Braga, Ana Rita Vaz
Publikováno v:
European journal of medicinal chemistry. 172
Herein we report novel hybrid compounds based on valproic acid and DNA-alkylating triazene moieties, 1, with therapeutic potential for glioblastoma multiforme chemotherapy. We identified hybrid compounds 1d and 1e to be remarkably more potent against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b532c962c109fb152f940a50fa2784b
https://pubmed.ncbi.nlm.nih.gov/30939350
https://pubmed.ncbi.nlm.nih.gov/30939350
Autor:
Maria de Jesus Perry, Ana E. Sousa, Fábio A Abade Dos Santos, João D. Pereira, Eduarda Mendes, Ana Paula Francisco, Susana Calado, Maria Manuela Gaspar
Publikováno v:
Bioorganicmedicinal chemistry. 25(15)
Metastatic melanoma still remains one the most difficult cancers to overcome. The aim of our research was the design of anti-tumour triazene compounds 3 for application to a melanoma-specific therapy. The strategy exploits the unique enzyme pathway o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47a0fd67dee1c7b47dd32c223f6aa5b8
https://pubmed.ncbi.nlm.nih.gov/28602669
https://pubmed.ncbi.nlm.nih.gov/28602669
Publikováno v:
Comprehensive Organic Chemistry Experiments for the Laboratory Classroom ISBN: 9781849739634
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bfe74b036e3fb9566655c0d014dac6d
https://doi.org/10.1039/9781849739634-00754
https://doi.org/10.1039/9781849739634-00754