N-palmitoyl-vanillamide (palvanil) is a non-pungent analogue of capsaicin with stronger desensitizing capability against the TRPV1 receptor and anti-hyperalgesic activity

Autor: Francesca Guida, Vincenzo Di Marzo, Aniello Schiano Moriello, Luciano De Petrocellis, Fabiana Piscitelli, Maria De Chiaro, Sabatino Maione, Vito de Novellis

Publikováno v: Pharmacological research
63 (2011): 294–299. doi:10.1016/j.phrs.2010.12.019
info:cnr-pdr/source/autori:De Petrocellis L., Guida F., Schiano Moriello A., De Chiaro M., Piscitelli F., de Novellis V., Maione S., and Di Marzo V./titolo:N-palmitoyl-vanillamide (palvanil) is a non-pungent analogue of capsaicin with stronger desensitizing capability against the TRPV1 receptor and potential anti-hyperalgesic activity/doi:10.1016%2Fj.phrs.2010.12.019/rivista:Pharmacological research (Print)/anno:2011/pagina_da:294/pagina_a:299/intervallo_pagine:294–299/volume:63

N-acyl-vanillamide (NAVAM) analogues of the natural pungent principle of capsicum, capsaicin, were developed several years ago as potential non-pungent analgesic compounds. N-oleoyl-vanillamide (olvanil) and N-arachidonoy-vanillamide (arvanil), in pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bddab61131294b61d32ec2fbbb6ce105
https://doi.org/10.1016/j.phrs.2010.12.019

Dorsal striatum metabotropic glutamate receptor 8 affects nocifensive responses and rostral ventromedial medulla cell activity in neuropathic pain conditions

Autor: Vito de Novellis, Francesca Guida, Ida Marabese, Catia Giordano, Maria De Chiaro, Enza Palazzo, Sabatino Maione, Danilo De Gregorio, Livio Luongo, Francesca Rossi, Serena Boccella

The present study investigated the role of metabotropic glutamate receptor subtype 8 (mGluR8) in the dorsal striatum (DS) in modulating thermonociception and rostral ventromedial medulla (RVM) ON and OFF cell activities in conditions of neuropathic p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e29c0e1862aea6fc78071fcc56c68c0e

Salvinorin A reduces mechanical allodynia and spinal neuronal hyperexcitability induced by peripheral formalin injection

Autor: Livio Luongo, Serena Boccella, Raffaele Capasso, Vito de Novellis, Enza Palazzo, Francesca Guida, Gabriella Aviello, Ida Marabese, Sabatino Maione, Angelo A. Izzo, Maria De Chiaro, Jordan K. Zjawiony, Luisa Gatta

Publikováno v: Molecular Pain
Molecular Pain, Vol 8, Iss 1, p 60 (2012)

Background: Salvinorin A (SA), the main active component of Salvia Divinorum, is a non-nitrogenous kappa opioid receptor (KOR) agonist. It has been shown to reduce acute pain and to exert potent antinflammatory effects. This study assesses the effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb205f8ed44134eca207cb96018cdd0a
http://hdl.handle.net/11591/198170

Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 4. Identification of New Potent and Selective Ligands for the Cannabinoid Type 2 Receptor with Diverse Substitution Patterns and Antihyperalgesic Effects in Mice

Autor: Alessia Ligresti, Livio Luongo, Maria De Chiaro, Serena Pasquini, Federico Corelli, Francesca Guida, Maria Frosini, Valentina Pedani, Vincenzo Di Marzo, Claudia Mugnaini, Sabatino Maione, Stefania Dragoni, Maria Cristina De Rosa

Publikováno v: Journal of medicinal chemistry 54 (2011): 5444–5453.
info:cnr-pdr/source/autori:Pasquini S, De Rosa M, Pedani V, Mugnaini C, Guida F, Luongo L, De Chiaro M, Maione S, Dragoni S, Frosini M, Ligresti A, Di Marzo V, Corelli F./titolo:Investigations on the 4-quinolone-3-carboxylic acid motif. 4. Identification of new potent and selective ligands for the cannabinoid type 2 receptor with diverse substitution patterns and antihyperalgesic effects in mice./doi:/rivista:Journal of medicinal chemistry/anno:2011/pagina_da:5444/pagina_a:5453/intervallo_pagine:5444–5453/volume:54

Experimental evidence suggests that selective CB2 receptor modulators may provide access to antihyperalgesic agents devoid of psychotropic effects. Taking advantage of previous findings on structure-activity/selectivity relationships for a class of 4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ca1f9329884d62325332cd8ad048a7
http://hdl.handle.net/11365/4091

Investigations on the 4-quinolone-3-carboxylic acid motif. 3. Synthesis, structure-affinity relationships, and pharmacological characterization of 6-substituted 4-quinolone-3-carboxamides as highly selective cannabinoid-2 receptor ligands

Autor: Francesca Guida, Lavinia Cicione, Federico Corelli, Claudia Mugnaini, Roger G. Pertwee, Teresa Semeraro, Maria De Chiaro, Serena Pasquini, Livio Luongo, Vincenzo Di Marzo, Daniele Bolognini, Maria Grazia Cascio, Sabatino Maione, Pietro Marini, Maria Cristina De Rosa, Alessia Ligresti

Publikováno v: Journal of medicinal chemistry 53 (2010): 5915–5928.
info:cnr-pdr/source/autori:Pasquini S, Ligresti A, Mugnaini C, Semeraro T, Cicione L, De Rosa M, Guida F, Luongo L, De Chiaro M, Cascio MG, Bolognini D, Marini P, Pertwee R, Maione S, Di Marzo V, Corelli F./titolo:Investigations on the 4-quinolone-3-carboxylic acid motif. 3. Synthesis, structure-affinity relationships, and pharmacological characterization of 6-substituted 4-quinolone-3-carboxamides as highly selective cannabinoid-2 receptor ligands./doi:/rivista:Journal of medicinal chemistry/anno:2010/pagina_da:5915/pagina_a:5928/intervallo_pagine:5915–5928/volume:53

A set of quinolone-3-carboxamides 2 bearing diverse substituents at position 1, 3, and 6 of the bicyclic nucleus was prepared. Except for six compounds exhibiting Ki > 100 nM, all the quinolone-3-carboxamides 2 proved to be high affinity CB2 ligands,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f731f5ff70ab14c9c6058d123b03fb17
https://pubmed.ncbi.nlm.nih.gov/20718492