Výsledky vyhledávání - "Maria D. Odero"

Akademický článek

The Role of MYC and PP2A in the Initiation and Progression of Myeloid Leukemias

Publikováno v: Cells, Vol 9, Iss 3, p 544 (2020)

The MYC transcription factor is one of the best characterized PP2A substrates. Deregulation of the MYC oncogene, along with inactivation of PP2A, are two frequent events in cancer. Both proteins are essential regulators of cell proliferation, apoptos

Externí odkaz: https://doaj.org/article/d23f955b5c02497a9b41b732a7d5ce3c

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Akademický článek

Correction: 3′UTR-Mediated Gene Silencing of the Mixed Lineage Leukemia (MLL) Gene.

Autor: Maria Gomez-Benito, Fabricio Loayza-Puch, Joachim A. F. Oude Vrielink, Maria D. Odero, Reuven Agami

Publikováno v: PLoS ONE, Vol 6, Iss 11 (2011)

Externí odkaz: https://doaj.org/article/8b5d93c1b6fe4d268c41dd643b32dd47

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Akademický článek

In vitro validation of γ-secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia

Autor: Kim De Keersmaecker, Idoya Lahortiga, Nicole Mentens, Cedric Folens, Leander Van Neste, Sofie Bekaert, Peter Vandenberghe, Maria D. Odero, Peter Marynen, Jan Cools

Publikováno v: Haematologica, Vol 93, Iss 4 (2008)

Background Activating NOTCH1 mutations are common in T-cell acute lymphoblastic leukemia. Inhibition of NOTCH1 signaling with γ-secretase inhibitors causes cell cycle block, but only after treatment for several days. We further documented the effect

Externí odkaz: https://doaj.org/article/39823d40c1414292b05a844cedcf4544

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Activation of the PP2A-B56α heterocomplex synergizes with venetoclax therapies in AML through BCL2 and MCL1 modulation

Autor: Irene Peris, Silvia Romero-Murillo, Elena Martínez-Balsalobre, Caroline C. Farrington, Elena Arriazu, Nerea Marcotegui, Marta Jiménez-Muñoz, Cristina Alburquerque-Prieto, Andrea Torres-López, Vicente Fresquet, Jose A. Martínez-Climent, Maria C. Mateos, Maria L. Cayuela, Goutham Narla, Maria D. Odero, Carmen Vicente

Publikováno v: Blood. 141:1047-1059

Venetoclax combination therapies are becoming the standard of care in acute myeloid leukemia (AML). However, the therapeutic benefit of these drugs in older/unfit patients is limited to only a few months, highlighting the need for more effective ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42bad8f40671cd9ecfae213074da16a6
https://doi.org/10.1182/blood.2022016466

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Data from Endogenous Retroelement Activation by Epigenetic Therapy Reverses the Warburg Effect and Elicits Mitochondrial-Mediated Cancer Cell Death

For millions of years, endogenous retroelements have remained transcriptionally silent within mammalian genomes by epigenetic mechanisms. Modern anticancer therapies targeting the epigenetic machinery awaken retroelement expression, inducing antivira

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd38133a1d3d0fc69bfac72ef54132a
https://doi.org/10.1158/2159-8290.c.6549353.v1

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Supplementary Figures S1-S7 from Endogenous Retroelement Activation by Epigenetic Therapy Reverses the Warburg Effect and Elicits Mitochondrial-Mediated Cancer Cell Death

Supplementary Figures S1-S7 with legends

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04cd1ba7e34a4f91806bf9b7dfe5c665
https://doi.org/10.1158/2159-8290.22540328.v1

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Supplementary Data from Endogenous Retroelement Activation by Epigenetic Therapy Reverses the Warburg Effect and Elicits Mitochondrial-Mediated Cancer Cell Death

Resources Table and Suppl. Tables. S1-S3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45c062deac21564ce858ab3b68ff8059
https://doi.org/10.1158/2159-8290.22540331

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A novel t(7;13)(p12;q33 approximately q34) in AML-M2

Autor: Elvira, Gerbino, Cinzia, Tapinassi, Omar, Malazzi, Carla, Micucci, Maria J, Calasanz, Jose' M, Beltran-Heredia, Patrizia, Gasparini, Maria D, Odero, Pier Giuseppe, Pelicci, Elena, Belloni

Publikováno v: Cancer genetics and cytogenetics. 195(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e3c5af8791e272cb9dc5709d4b2dfa50
https://pubmed.ncbi.nlm.nih.gov/19963127

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De novo erythroleukemia chromosome features include multiple rearrangements, with special involvement of chromosomes 11 and 19

Autor: Juan C, Cigudosa, Maria D, Odero, M José, Calasanz, Francesc, Solé, Marta, Salido, Eva, Arranz, Angel, Martínez-Ramirez, Miguel, Urioste, Sara, Alvarez, Jose V, Cervera, Donald, MacGrogan, Miguel A, Sanz, Stephen D, Nimer, Javier, Benitez

Publikováno v: Genes, chromosomescancer. 36(4)

Erythroid leukemia (ERL or AML-M6) is an uncommon subtype of acute myeloid leukemia, the clinical, morphological, and genetic behavior of which needs further characterization. We analyzed a homogeneous group of 23 de novo AML-M6 patients whose bone m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::78c307c1ff5ed010b8acd28bbfdc604a
https://pubmed.ncbi.nlm.nih.gov/12619165

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NUP98 is fused to adducin 3 in a patient with T-cell acute lymphoblastic leukemia and myeloid markers, with a new translocation t(10;11)(q25;p15)

Autor: Lahortiga, I., Vizmanos, Jl, Agirre, X., Vazquez, I., Cigudosa, Jc, Larrayoz, Mj, Sala, F., Gorosquieta, A., Perez-Equiza, K., Calasanz, Mj, Maria D. Odero

Publikováno v: Dadun. Depósito Académico Digital de la Universidad de Navarra
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The nucleoporin 98 gene (NUP98) has been reported to be fused to 13 partner genes in hematological malignancies with 11p15 translocations. Twelve of them have been identified in patients with myeloid neoplasias and only 1, RAP1GDS1 (4q21), is fused w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::3705ac8a88950c2652e3464aae392b1f
https://hdl.handle.net/10171/19621

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