New Therapeutic Strategies for Osteoarthritis by Targeting Sialic Acid Receptors

Autor: Paula Carpintero-Fernandez, Marta Varela-Eirin, Alessandra Lacetera, Raquel Gago-Fuentes, Eduardo Fonseca, Sonsoles Martin-Santamaria, Maria D. Mayan

Publikováno v: Biomolecules, Vol 10, Iss 4, p 637 (2020)

Osteoarthritis (OA) is the most common degenerative joint disease characterized by articular cartilage degradation and joint degeneration. The articular cartilage is mainly formed by chondrocytes and a collagen-proteoglycan extracellular matrix that

Externí odkaz: https://doaj.org/article/2089dedd62ab4db8802943d48e5a297a

Connexin 43 regulates intercellular mitochondrial transfer from human mesenchymal stromal cells to chondrocytes

Autor: Rebecca M. Irwin, Matthew A. Thomas, Megan J. Fahey, María D. Mayán, James W. Smyth, Michelle L. Delco

Publikováno v: Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-13 (2024)

Abstract Background The phenomenon of intercellular mitochondrial transfer from mesenchymal stromal cells (MSCs) has shown promise for improving tissue healing after injury and has potential for treating degenerative diseases like osteoarthritis (OA)

Externí odkaz: https://doaj.org/article/0214e04d07ef423cb968386f6fd5e480

The coagulation factor IX (F9) loss of function prevents the cell cycle arrest induced by CDK4/6 inhibitors treatment

Autor: Michela Borghesan, Ana O'Loghlen, O Eleftheriadou, T Mitchell, Juan Fafián-Labora, Thomas D. Nightingale, Paula Carpintero-Fernández, Maria D. Mayan

SUMMARYDuring this last decade the development of pro-senescence therapies has become an attractive strategy as cellular senescence acts as a barrier against tumour progression. In this context, CDK4/6 inhibitors induce senescence and have showed eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c2b10ba6b9c00bf020f6e1db0bd764d
https://doi.org/10.1101/2021.11.30.470520

Intercellular communication via gap junction channels between chondrocytes and bone cells

Autor: Virginijus Valiunas, Peter R. Brink, Maria D. Mayan, Eduardo Fonseca, Raquel Gago-Fuentes, Hong Z. Wang, José R. Caeiro, Paula Carpintero-Fernández

Publikováno v: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1860:2499-2505

Cell-to-cell communication between bone, cartilage and the synovial membrane is not fully understood and it is only attributed to the diffusion of substances through the extracellular space or synovial fluid. In this study, we found for the first tim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53da4b8cd7792a406ac440d7c18e00cf
https://doi.org/10.1016/j.bbamem.2018.09.009

Senolytic Activity of Small Molecular Polyphenols from Olive Restores Chondrocyte Redifferentiation and Promotes a Pro-Regenerative Environment in Osteoarthritis

Autor: Alfonso Blanco, Antonio Casado-Díaz, Paula Carpintero-Fernández, Agustín Sánchez-Temprano, Mustapha Kandouz, M. Varela-Eirin, Maria D. Mayan, Adrian Varela-Vazquez, Alfonso Calañas Continente, Eduardo Fonseca, José R. Caeiro, Carlos L. Paíno, Virginia Mato

Publikováno v: RUC. Repositorio da Universidade da Coruña
instname
RUC: Repositorio da Universidade da Coruña
Universidade da Coruña (UDC)
Aging (Albany NY)

[Abstract] Articular cartilage and synovial tissue from patients with osteoarthritis (OA) show an overactivity of connexin43 (Cx43) and accumulation of senescent cells associated with disrupted tissue regeneration and disease progression. The aim of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c694dce7fb94080b515bb644f4a791ab
https://hdl.handle.net/2183/26271