Synthesis and Biological Evaluation of Novel 3-Alkylpyridine Marine Alkaloid Analogs with Promising Anticancer Activity

Autor: Alessandra Mirtes Marques Neves Gonçalves, Aline Brito de Lima, Maria Cristina da Silva Barbosa, Luiz Fernando de Camargos, Júlia Teixeira de Oliveira, Camila de Souza Barbosa, José Augusto Ferreira Perez Villar, André Carvalho Costa, Isabella Viana Gomes da Silva, Luciana Maria Silva, Fernando de Pilla Varotti, Fabio Vieira dos Santos, Gustavo Henrique Ribeiro Viana

Publikováno v: Marine Drugs, Vol 12, Iss 8, Pp 4361-4378 (2014)

Cancer continues to be one of the most important health problems worldwide, and the identification of novel drugs and treatments to address this disease is urgent. During recent years, marine organisms have proven to be a promising source of new comp

Externí odkaz: https://doaj.org/article/66d71e056f16441ea56b1a73d6e09d5a

Annona coriacea Mart. Fractions Promote Cell Cycle Arrest and Inhibit Autophagic Flux in Human Cervical Cancer Cell Lines

Autor: Bruno G. Oliveira, Wanderson Romão, Renato José Silva-Oliveira, Rui Manuel Reis, Izabela Natalia Faria Gomes, Marcela N. Rosa, Maria Cristina Da Silva Barbosa, Fábio Vieira dos Santos, Viviane Aline Oliveira Silva, Patrik Da Silva Vital, João Gabriel M. Junqueira, Rosy Iara Maciel de Azambuja Ribeiro, Vanessa Gisele Pasqualotto Severino

Publikováno v: Molecules, Vol 24, Iss 21, p 3963 (2019)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Molecules
Volume 24
Issue 21

Plant-based compounds are an option to explore and perhaps overcome the limitations of current antitumor treatments. Annona coriacea Mart. is a plant with a broad spectrum of biological activities, but its antitumor activity is still unclear. The pur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1125a1eb7174e79b359730c9203fd7a9
https://www.mdpi.com/1420-3049/24/21/3963

Digoxin reduces the mutagenic effects of Mitomycin C in human and rodent cell lines

Autor: Maria Cristina Da Silva Barbosa, Juliana Pereira Lyon, Fernando de Pilla Varotti, Leonardo Marmo Moreira, Luciana Madeira da Silva, Isabella Viana Gomes da Silva, Luiz Fernando de Camargos, Vanessa J. S. V. Santos, Fábio Vieira dos Santos, Júlia Teixeira de Oliveira

Digoxin is a drug widely used to treat heart failure and studies have demonstrated its potential as anticancer agent. In addition, digoxin presents the potential to interact with a series of other compounds used in medicine. The aim of the present st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::283b62c8ef7eef9e14a728408f6bcb41
https://europepmc.org/articles/PMC5507848/