Promising potential of articaine-loaded poly(epsilon-caprolactone) nanocapules for intraoral topical anesthesia.

Autor: Camila Batista da Silva, Maria Cristina Volpato, Bruno Vilela Muniz, Cleiton Pita Dos Santos, Luciano Serpe, Luiz Eduardo Nunes Ferreira, Nathalie Ferreira Silva de Melo, Leonardo Fernandes Fraceto, Francisco Carlos Groppo, Michelle Franz-Montan

Publikováno v: PLoS ONE, Vol 16, Iss 2, p e0246760 (2021)

To determine whether the permeation capacity and analgesic efficacy of articaine (ATC) could be increased and cytotoxicity decreased by encapsulation in poly(ɛ-caprolactone) nanocapsules (ATCnano), aiming at local or topical anesthesia in dentistry.

Externí odkaz: https://doaj.org/article/10f57da97928452090b51bb7442062d8

Methylparaben concentration in commercial Brazilian local anesthetics solutions

Autor: Gustavo Henrique Rodriguez da Silva, Carla Beatriz Grespan Bottoli, Francisco Carlos Groppo, Maria Cristina Volpato, José Ranali, Juliana Cama Ramacciato, Rogério Heládio Lopes Motta

Publikováno v: Journal of Applied Oral Science, Vol 20, Iss 4, Pp 444-448 (2012)

OBJECTIVE: To detect the presence and concentration of methylparaben in cartridges of commercial Brazilian local anesthetics. MATERIAL AND METHODS: Twelve commercial brands (4 in glass and 8 in plastic cartridges) of local anesthetic solutions for us

Externí odkaz: https://doaj.org/article/827d756ae44d4e7daeba0c669c601b55

Analgesic choice in dentistry. Part I: The mechanism of action

Autor: Filipe Polese Branco, Marcos Luciano Pimenta Pinheiro, Maria Cristina Volpato, Eduardo Dias de Andrade

Publikováno v: Brazilian Journal of Oral Sciences, Vol 4, Iss 14 (2015)

Analgesics are frequently used in dentistry for the management of dental pain. Dental clinicians should choose the medicine based on its mechanism of action and toxicity, to promote a successful analgesic effect as well as comfort to the patient. The

Externí odkaz: https://doaj.org/article/194fb26b6405425aadf645f7f5e0d707

Resistivity Technique for the Evaluation of the Integrity of Buccal and Esophageal Epithelium Mucosa for In Vitro Permeation Studies: Swine Buccal and Esophageal Mucosa Barrier Models

Autor: Gabriela Gama Augusto Xavier, Jaiza Samara Macena de Araújo, Francisco Carlos Groppo, Claudia Cristina Maia Martinelli, Bruno Vilela Muniz, Renata Fonseca Vianna Lopez, Michelle Franz-Montan, Maria Cristina Volpato

Publikováno v: Pharmaceutics
Volume 13
Issue 5
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Pharmaceutics, Vol 13, Iss 643, p 643 (2021)

Permeation assays are important for the development of topical formulations applied on buccal mucosa. Swine buccal and esophageal epithelia are usually used as barriers for these assays, while frozen epithelia have been used to optimize the experimen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc0d0d02791974b0f48876e33f69fc55

A crossover clinical study to evaluate pain intensity from microneedle insertion in different parts of the oral cavity

Autor: Gabriela Gama Xavier Augusto, Henrique Ballassin Abdalla, Stephany Di Carla Santos, Maria Cristina Volpato, Nadia Cristina Favaro-Moreira, Francisco Carlos Groppo, Yuri Martins Costa, Michelle Franz-Montan, Harvinder S. Gill

Publikováno v: Int J Pharm

The objective of the present study was to evaluate discomfort and safety of microneedle (MN) insertion in several intraoral regions. A device was developed to standardize MN insertions. MNs were inserted in the following regions of the oral cavity: g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e001c4956b26f0a6eb9a3ef2109b40db
https://pubmed.ncbi.nlm.nih.gov/33161036