Zobrazeno 1 - 10
of 346
pro vyhledávání: '"Maria Cristina Mingari"'
Autor:
Ombretta Garbarino, Giulia Elda Valenti, Lorenzo Monteleone, Gabriella Pietra, Maria Cristina Mingari, Andrea Benzi, Santina Bruzzone, Silvia Ravera, Riccardo Leardi, Emanuele Farinini, Stefania Vernazza, Melania Grottoli, Barbara Marengo, Cinzia Domenicotti
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundMalignant melanoma is the most lethal form of skin cancer which shows BRAF mutation in 50% of patients. In this context, the identification of BRAFV600E mutation led to the development of specific inhibitors like PLX4032. Nevertheless, alth
Externí odkaz:
https://doaj.org/article/b8c698a0f07f4ca591628ff66b119098
Autor:
Claudia Cantoni, Michela Falco, Massimo Vitale, Gabriella Pietra, Enrico Munari, Daniela Pende, Maria Cristina Mingari, Simona Sivori, Lorenzo Moretta
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
The long story of NK cells started about 50 y ago with the first demonstration of a natural cytotoxic activity within an undefined subset of circulating leukocytes, has involved an ever-growing number of researchers, fascinated by the apparently easy
Externí odkaz:
https://doaj.org/article/bd0d6b7413d1468ca95bb84de00f4265
Autor:
Nicola Tumino, Francesca Besi, Stefania Martini, Anna Laura Di Pace, Enrico Munari, Linda Quatrini, Andrea Pelosi, Piera Filomena Fiore, Giulia Fiscon, Paola Paci, Francesca Scordamaglia, Maria Grazia Covesnon, Giuseppe Bogina, Maria Cristina Mingari, Lorenzo Moretta, Paola Vacca
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Tumor microenvironment (TME) includes a wide variety of cell types and soluble factors capable of suppressing immune-responses. While the role of NK cells in TME has been analyzed, limited information is available on the presence and the effect of po
Externí odkaz:
https://doaj.org/article/7fc694cfd7434346a3d032af14260c4f
Autor:
Melania Grottoli, Paolo Carrega, Lodovica Zullo, Chiara Dellepiane, Giovanni Rossi, Francesca Parisi, Giulia Barletta, Linda Zinoli, Simona Coco, Angela Alama, Silvia Marconi, Monica Parodi, Paola Orecchia, Sara Bassi, Massimo Vitale, Maria Cristina Mingari, Ulrich Pfeffer, Carlo Genova, Gabriella Pietra
Publikováno v:
Cancers, Vol 14, Iss 20, p 5046 (2022)
Immune checkpoint inhibitors (ICIs) immunotherapy has represented a breakthrough in cancer treatment. Clinical use of ICIs has shown an acceptable safety profile and promising antitumor activity. Nevertheless, some patients do not obtain clinical ben
Externí odkaz:
https://doaj.org/article/e1858f7b7b8744cdac78d7d746e58231
Cord Blood-Derived Natural Killer Cell Exploitation in Immunotherapy Protocols: More Than a Promise?
Autor:
Laura Damele, Grazia Maria Spaggiari, Monica Parodi, Maria Cristina Mingari, Massimo Vitale, Chiara Vitale
Publikováno v:
Cancers, Vol 14, Iss 18, p 4439 (2022)
In the last 20 years, Natural Killer (NK) cell-based immunotherapy has become a promising approach to target various types of cancer. Indeed, NK cells play a pivotal role in the first-line defense against tumors through major histocompatibility compl
Externí odkaz:
https://doaj.org/article/36359aaff2de43538cb88615515641ae
Autor:
Iva Filipovic, Laura Chiossone, Paola Vacca, Russell S. Hamilton, Tiziano Ingegnere, Jean-Marc Doisne, Delia A. Hawkes, Maria Cristina Mingari, Andrew M. Sharkey, Lorenzo Moretta, Francesco Colucci
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Studying the uterine lymphocyte pool is difficult due to its dynamic nature induced by various pregnancy-related factors. Here the authors provide, using transcriptome data from sorted mouse group 1 innate lymphoid cells (ILC), a molecular atlas of t
Externí odkaz:
https://doaj.org/article/94147fd056164a368caaea3b7a7234be
Inhibitory Receptors and Checkpoints in Human NK Cells, Implications for the Immunotherapy of Cancer
Autor:
Simona Sivori, Mariella Della Chiesa, Simona Carlomagno, Linda Quatrini, Enrico Munari, Paola Vacca, Nicola Tumino, Francesca Romana Mariotti, Maria Cristina Mingari, Daniela Pende, Lorenzo Moretta
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The highly destructive mechanisms by which the immune system faces microbial infections is under the control of a series of inhibitory receptors. While most of these receptors prevent unwanted/excessive responses of individual effector cells, others
Externí odkaz:
https://doaj.org/article/c1f40604c39a473b9c81825e3389f6ce
Autor:
Andrea Pelosi, Claudia Alicata, Nicola Tumino, Tiziano Ingegnere, Fabrizio Loiacono, Maria Cristina Mingari, Lorenzo Moretta, Paola Vacca
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Innate lymphoid cells (ILCs) are a heterogeneous subset of lymphocytes deeply implicated in the innate immune responses to different pathogens, in lymphoid organogenesis and in the maintenance of tissue homeostasis. Group 3 innate lymphoid cells (ILC
Externí odkaz:
https://doaj.org/article/5e53caf9e87449bb8d20417d64593882
Autor:
Selene Ottonello, Carlo Genova, Irene Cossu, Vincenzo Fontana, Erika Rijavec, Giovanni Rossi, Federica Biello, Maria Giovanna Dal Bello, Marco Tagliamento, Angela Alama, Simona Coco, Simona Boccardo, Irene Vanni, Guido Ferlazzo, Lorenzo Moretta, Francesco Grossi, Maria Cristina Mingari, Paolo Carrega, Gabriella Pietra
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Immune checkpoint blockade represents a major breakthrough in advanced non-small cell lung cancer (NSCLC) therapy. However, success is limited to a subset of patients and there is a critical need to identify robust biomarkers associated with clinical
Externí odkaz:
https://doaj.org/article/d2bc4156441047f087b7ab4cc39af254
Autor:
Paola Vacca, Gabriella Pietra, Nicola Tumino, Enrico Munari, Maria Cristina Mingari, Lorenzo Moretta
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
NK cells play an important role in the innate defenses against tumor growth and metastases. Human NK cell activation and function are regulated by an array of HLA class I-specific inhibitory receptors and activating receptors recognizing ligands expr
Externí odkaz:
https://doaj.org/article/c59929bb5dc94d338fc5ba318f43e3d7