Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Maria Consuelo Alonso Canizal"'
Autor:
Regina Messerer, Luca Agnetta, Carsten Hoffmann, Ulrike Holzgrabe, Maria Consuelo Alonso Canizal, Michael Decker, Michael Kauk
Publikováno v:
Angewandte Chemie. 129:7388-7393
Uber die Art und den zeitlichen Verlauf der Aktivierung von G-Protein-gekoppelten Rezeptoren (GPCRs), insbesondere der muskarinischen Acetylcholinrezeptoren (mACh- oder M-Rezeptoren), ist trotz der enormen therapeutischen Relevanz von M-Rezeptoren un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19f194052521672abd354863ac22c57e
https://doi.org/10.1002/ange.201701524
https://doi.org/10.1002/ange.201701524
Autor:
Ulrike Zabel, Carsten Hoffmann, Jessika Klöckner, Susanne Nuber, Michael Kauk, Regina Messerer, Maria Consuelo Alonso Canizal, Daniela Volpato, Ulrike Holzgrabe
Publikováno v:
ACS Chemical Biology. 12:833-843
Aiming to design partial agonists as well as allosteric modulators for the M1 muscarinic acetylcholine (M1AChR) receptor, two different series of bipharmacophoric ligands and their structural analogues were designed and synthesized. The hybrids were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4d2fb6fd669960d0cf18f1b3cbbc4a2
https://doi.org/10.1021/acschembio.6b00828
https://doi.org/10.1021/acschembio.6b00828
Autor:
Michael Decker, Michael Kauk, Luca Agnetta, Maria Consuelo Alonso Canizal, Ulrike Holzgrabe, Carsten Hoffmann, Regina Messerer
Publikováno v:
Angewandte Chemie (International ed. in English). 56(25)
The investigation of the mode and time course of the activation of G-protein-coupled receptors (GPCRs), in particular muscarinic acetylcholine (mACh or M) receptors, is still in its infancy despite the tremendous therapeutic relevance of M receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::222c47c73ee2f19333b0df1150eb2930
https://pubmed.ncbi.nlm.nih.gov/28510314
https://pubmed.ncbi.nlm.nih.gov/28510314
Autor:
Regina, Messerer, Michael, Kauk, Daniela, Volpato, Maria Consuelo, Alonso Canizal, Jessika, Klöckner, Ulrike, Zabel, Susanne, Nuber, Carsten, Hoffmann, Ulrike, Holzgrabe
Publikováno v:
ACS chemical biology. 12(3)
Aiming to design partial agonists as well as allosteric modulators for the M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::542ef3a06c366d7a0b6bd5560572964d
https://pubmed.ncbi.nlm.nih.gov/28117571
https://pubmed.ncbi.nlm.nih.gov/28117571
Autor:
Paweł Kozielewicz, Ainoleena Turku, Carl-Fredrik Bowin, Julian Petersen, Jana Valnohova, Maria Consuelo Alonso Cañizal, Yuki Ono, Asuka Inoue, Carsten Hoffmann, Gunnar Schulte
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
WNT-Frizzled (FZD) signaling plays a critical role in embryonic development, tissue homeostasis and human disease but no small molecule drugs targeting FZD with distinct efficacy have emerged so far. Here, authors identify the Smoothened agonist SAG1
Externí odkaz:
https://doaj.org/article/cdfb04c677084c808ef1126575dae7a6
Autor:
Jakub Harnoš, Maria Consuelo Alonso Cañizal, Miroslav Jurásek, Jitender Kumar, Cornelia Holler, Alexandra Schambony, Kateřina Hanáková, Ondřej Bernatík, Zbyněk Zdráhal, Kristína Gömöryová, Tomáš Gybeľ, Tomasz Witold Radaszkiewicz, Marek Kravec, Lukáš Trantírek, Jan Ryneš, Zankruti Dave, Ana Iris Fernández-Llamazares, Robert Vácha, Konstantinos Tripsianes, Carsten Hoffmann, Vítězslav Bryja
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Dishevelled (DVL) is the key component of Wnt signaling pathway that acts as a signaling hub. Here, authors study the conformational dynamics of DVL3 in vivo using their engineered FlAsH-based FRET biosensors and describe how Wnt activation opens DVL
Externí odkaz:
https://doaj.org/article/c656ec6d84244ea4ba47e39232d91995