Výsledky vyhledávání - "Maria Concetta Veri"

Application of dual affinity retargeting molecules to achieve optimal redirected T-cell killing of B-cell lymphoma

Autor: G. Jonah Rainey, Valentina Ciccarone, Linda Jin, Sudeepta Aggarwal, Ezio Bonvini, Yinhua Yang, Wenjun Zhang, Paul A. Moore, Steve Burke, Syd Johnson, Sunan Zhang, Leilei He, Maria Concetta Veri, Scott Koenig, Kalpana Shah, Ling Huang, Sergey Gorlatov, Tengfei Zhang, Hua Li

Publikováno v: Blood. 117:4542-4551

We describe the application of a novel, bispecific antibody platform termed dual affinity retargeting (DART) to eradicate B-cell lymphoma through coengagement of the B cell–specific antigen CD19 and the TCR/CD3 complex on effector T cells. Comparis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::592341cafb9e92c114f5f999aab74a69
https://doi.org/10.1182/blood-2010-09-306449

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CD32B, the human inhibitory Fc-γ receptor IIB, as a target for monoclonal antibody therapy of B-cell lymphoma

Autor: Ezio Bonvini, Sergey Gorlatov, Christopher Rankin, Scott Koenig, Ling Huang, Nadine Tuaillon, H. David Inzunza, Shannon Thomas, Syd Johnson, Jeffrey B. Stavenhagen, Steve Burke, Maria-Concetta Veri, Hua Li

Publikováno v: Blood. 108:2384-2391

Human CD32B (FcγRIIB), the low-affinity inhibitory receptor for IgG, is the predominant Fc receptor (FcR) present on B cells. Immunohistochemical and expression studies have identified CD32B expression in a variety of B-cell malignancies, suggesting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16b7c05f4e95fb9ebda15fcc56f7c399
https://doi.org/10.1182/blood-2006-05-020602

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Activating and inhibitory IgG Fc receptors on human DCs mediate opposing functions

Autor: Jeffrey V. Ravetch, Adam Boruchov, Glenn Heller, Maria-Concetta Veri, James W. Young, Ezio Bonvini

Publikováno v: The Journal of Clinical Investigation, 115(10), 2914-2923. AMER SOC CLINICAL INVESTIGATION INC

Human monocyte-derived DCs (moDCs) and circulating conventional DCs coexpress activating (CD32a) and inhibitory (CD32b) isoforms of IgG Fc gamma receptor (Fc gamma R)II (CD32). The balance between these divergent receptors establishes a threshold of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72c0f3c387b786f42a6b04e6df5c0d1d
https://research.rug.nl/en/publications/f2f77975-008c-4b06-b33e-97bbb672b2bf

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A dynamic constitutive and inducible binding of c-Cbl by PLCγ1 SH3 and SH2 domains (negatively) regulates antigen receptor-induced PLCγ1 activation in lymphocytes

Autor: Laurie J. Graham, Cristiana Noviello, Alexander Y. Tysgankov, Karen E. DeBell, Maria-Concetta Veri, Ezio Bonvini, Barbara L. Rellahan

Publikováno v: Experimental Cell Research. 289:184-194

We investigated the structural requirements for c-Cbl-mediated inhibition of Ag receptor-induced PLCgamma1 activation. Analysis of site-specific c-Cbl mutants indicated that tyrosine phosphorylation of c-Cbl was required for down-regulation of the PL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff3feffbcd69feb3471fb7cdb621de0
https://doi.org/10.1016/s0014-4827(03)00260-x

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70Z/3 Cbl induces PLCγ1 activation in T lymphocytes via an alternate Lat- and Slp-76-independent signaling mechanism

Autor: Barbara L. Rellahan, Maria-Concetta Veri, Karen E. DeBell, Cristiana Noviello, Laurie J. Graham, Sandy Jen, Ezio Bonvini, Rashmi Rawat

Publikováno v: Oncogene. 22:2493-2503

The oncoprotein 70Z/3 Cbl signals in an autonomous fashion or through blockade of endogenous c-Cbl, a negative regulator of signaling. The mechanism of 70Z/3 Cbl-induced signaling was investigated by comparing the molecular requirements for 70Z/3 Cbl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b552210f73a3e3d419444ee2798063a3
https://doi.org/10.1038/sj.onc.1206318

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Therapeutic control of B cell activation via recruitment of Fcgamma receptor IIb (CD32B) inhibitory function with a novel bispecific antibody scaffold

Autor: Ling Huang, Lida Ning, Scott Koenig, Tamara Minor, Syd Johnson, Maria-Concetta Veri, Linda Jin, Stephen P. Burke, Sergey Gorlatov, Ezio Bonvini, Nadine Tuaillon, Valentina Ciccarone, Kay Shah, Paul A. Moore, G. Jonah Rainey, Tengfei Zhang, Hua Li

Publikováno v: Arthritis and rheumatism. 62(7)

Objective To exploit the physiologic Fcgamma receptor IIb (CD32B) inhibitory coupling mechanism to control B cell activation by constructing a novel bispecific diabody scaffold, termed a dual-affinity retargeting (DART) molecule, for therapeutic appl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::118771df51fb57663b4d719bbf8938c0
https://pubmed.ncbi.nlm.nih.gov/20506263

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Selective blockade of the inhibitory Fcgamma receptor (FcgammaRIIB) in human dendritic cells and monocytes induces a type I interferon response program

Autor: Jeffrey V. Ravetch, Madhav V. Dhodapkar, Anjli Kukreja, Kavita M. Dhodapkar, Ralph M. Steinman, Elyana Matayeva, Devi Banerjee, Maria Concetta Veri, John E. Connolly

Publikováno v: The Journal of Experimental Medicine

The ability of dendritic cells (DCs) to activate immunity is linked to their maturation status. In prior studies, we have shown that selective antibody-mediated blockade of inhibitory FcgammaRIIB receptor on human DCs in the presence of activating im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87311dd8e68ca4aa79824e6b1961c415
https://pubmed.ncbi.nlm.nih.gov/17502666

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A new tyrosine phosphorylation site in PLC gamma 1: the role of tyrosine 775 in immune receptor signaling

Autor: Laurie Graham, Ezio Bonvini, Karen Debell, Carmen J. Serrano, Barbara L. Rellahan, Maria Concetta Veri, Ilona G. Reischl, Rashmi Rawat

Publikováno v: Scopus-Elsevier

Phospholipase Cγ (PLCγ) is a ubiquitous gatekeeper of calcium mobilization and diacylglycerol-mediated events induced by the activation of Ag and growth factor receptors. The activity of PLCγ is regulated through its controlled membrane translocat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84b7b99715b3268bac23f78e80202a88
https://pubmed.ncbi.nlm.nih.gov/15879121

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