Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Maria Colomé-Tatché"'
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-29 (2023)
Abstract Background Xenobiotics are primarily metabolized by hepatocytes in the liver, and primary human hepatocytes are the gold standard model for the assessment of drug efficacy, safety, and toxicity in the early phases of drug development. Recent
Externí odkaz:
https://doaj.org/article/6a8da7ef286c4c96aed02998d51eb792
Autor:
Akshaya Ramakrishnan, Aikaterini Symeonidi, Patrick Hanel, Katharina T. Schmid, Maria L. Richter, Michael Schubert, Maria Colomé-Tatché
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Single-cell open chromatin profiling via scATAC-seq has become a mainstream measurement of open chromatin in single-cells. Here we present epiAneufinder, an algorithm that exploits the read count information from scATAC-seq data to extract g
Externí odkaz:
https://doaj.org/article/c6f514beecf84288b337adedb6945b8f
Autor:
Anja S. Swoboda, Vanessa C. Arfelli, Anna Danese, Roland Windisch, Paul Kerbs, Enric Redondo Monte, Johannes W. Bagnoli, Linping Chen-Wichmann, Alessandra Caroleo, Monica Cusan, Stefan Krebs, Helmut Blum, Michael Sterr, Wolfgang Enard, Tobias Herold, Maria Colomé-Tatché, Christian Wichmann, Philipp A. Greif
Publikováno v:
HemaSphere, Vol 7, Iss 10, p e958 (2023)
Activating colony-stimulating factor-3 receptor gene (CSF3R) mutations are recurrent in acute myeloid leukemia (AML) with t(8;21) translocation. However, the nature of oncogenic collaboration between alterations of CSF3R and the t(8;21) associated RU
Externí odkaz:
https://doaj.org/article/94becda414dc465bba3fb42b380085d1
Autor:
Anna Danese, Maria L. Richter, Kridsadakorn Chaichoompu, David S. Fischer, Fabian J. Theis, Maria Colomé-Tatché
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
The authors present epiScanpy: a computational framework for the analysis of single-cell epigenomic data, both ATAC-seq and DNA methylation data, with examples for clustering, cell type identification, trajectory learning and atlas integration - and
Externí odkaz:
https://doaj.org/article/080e8714432f46029536734062f84ff2
Autor:
Yadollah Shahryary, Aikaterini Symeonidi, Rashmi R. Hazarika, Johanna Denkena, Talha Mubeen, Brigitte Hofmeister, Thomas van Gurp, Maria Colomé-Tatché, Koen J.F. Verhoeven, Gerald Tuskan, Robert J. Schmitz, Frank Johannes
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-22 (2020)
Abstract Stochastic changes in DNA methylation (i.e., spontaneous epimutations) contribute to methylome diversity in plants. Here, we describe AlphaBeta, a computational method for estimating the precise rate of such stochastic events using pedigree-
Externí odkaz:
https://doaj.org/article/61ed9b5876c743479bc2eb35c96c2191
Autor:
Brigitte T. Hofmeister, Johanna Denkena, Maria Colomé-Tatché, Yadollah Shahryary, Rashmi Hazarika, Jane Grimwood, Sujan Mamidi, Jerry Jenkins, Paul P. Grabowski, Avinash Sreedasyam, Shengqiang Shu, Kerrie Barry, Kathleen Lail, Catherine Adam, Anna Lipzen, Rotem Sorek, Dave Kudrna, Jayson Talag, Rod Wing, David W. Hall, Daniel Jacobsen, Gerald A. Tuskan, Jeremy Schmutz, Frank Johannes, Robert J. Schmitz
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-27 (2020)
Abstract Background Plants can transmit somatic mutations and epimutations to offspring, which in turn can affect fitness. Knowledge of the rate at which these variations arise is necessary to understand how plant development contributes to local ada
Externí odkaz:
https://doaj.org/article/d9fed2a5f73b4c1bb6b676c6bc03fbb1
Autor:
Courtney W. Hanna, Raquel Pérez-Palacios, Lenka Gahurova, Michael Schubert, Felix Krueger, Laura Biggins, Simon Andrews, Maria Colomé-Tatché, Deborah Bourc’his, Wendy Dean, Gavin Kelsey
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-17 (2019)
Abstract Background Genomic imprinting is an epigenetic phenomenon that allows a subset of genes to be expressed mono-allelically based on the parent of origin and is typically regulated by differential DNA methylation inherited from gametes. Imprint
Externí odkaz:
https://doaj.org/article/1f13e69e51574ec4ae0c64c683c949cc
Autor:
Aaron Taudt, David Roquis, Amaryllis Vidalis, René Wardenaar, Frank Johannes, Maria Colomé-Tatché
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-14 (2018)
Abstract Background Whole-genome bisulfite sequencing (WGBS) has become the standard method for interrogating plant methylomes at base resolution. However, deep WGBS measurements remain cost prohibitive for large, complex genomes and for population-l
Externí odkaz:
https://doaj.org/article/27fd02213d234fc9a07ad52687d5f37e
Publikováno v:
Blood. 140:9115-9116
Autor:
Akshaya Ramakrishnan, Aikaterini Symeonidi, Patrick Hanel, Michael Schubert, Maria Colomé-Tatché
Single-cell open chromatin profiling via the single-cell Assay for Transposase-Accessible Chromatin using sequencing (scATAC-seq) assay has become a mainstream measurement of open chromatin in single-cells. Here we present a novel algorithm, epiAneuf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f186141f20112dd6c8ed800f82928bc1
https://doi.org/10.1101/2022.04.03.485795
https://doi.org/10.1101/2022.04.03.485795