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pro vyhledávání: '"Maria Cirinnà"'
Bcl-2 expression restores the leukemogenic potential of a BCR/ABL mutant defective in transformation
Autor:
Plamen Kossev, Bruno Calabretta, Paolo Salomoni, Mariusz A. Wasik, Danilo Perrotti, Rossana Trotta, Maria Cirinnà
Publikováno v:
Blood. 96:3915-3921
Growth factor-dependent hematopoietic cell lines expressing the BCR/ABL oncoprotein of the Ph chromosome show growth factor-independent proliferation and resistance to apoptosis. Apoptosis resistance of BCR/ABL-expressing cells may depend on enhanced
Autor:
Emanuela Grassilli, Silvia Lombardini, Maria Cirinnà, Bruno Calabretta, Pier Paolo Claudio, Angela Iervolino, Vincenzo Cesi, Danilo Perrotti, Silvia Bonatti
Publikováno v:
Molecular and Cellular Biology. 20:6159-6169
The DNA binding activity of FUS (also known as TLS), a nuclear pro-oncogene involved in multiple translocations, is regulated by BCR-ABL in a protein kinase CbetaII (PKCbetaII)-dependent manner. We show here that in normal myeloid progenitor cells FU