Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Maria Chatzifrangkeskou"'
Autor:
Caroline Le Dour, Maria Chatzifrangkeskou, Coline Macquart, Maria M. Magiera, Cécile Peccate, Charlène Jouve, Laura Virtanen, Tiina Heliö, Katriina Aalto-Setälä, Silvia Crasto, Bruno Cadot, Déborah Cardoso, Nathalie Mougenot, Daniel Adesse, Elisa Di Pasquale, Jean-Sébastien Hulot, Pekka Taimen, Carsten Janke, Antoine Muchir
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Lamin A/C gene mutations cause dilated cardiomyopathy associated with cofilin-1 phosphorylation and actin destabilization. Here, the authors show that phosphorylated cofilin-1 blunts the MRTF-A/SRF axis, leading to decreased tubulin acetylation and a
Externí odkaz:
https://doaj.org/article/ef932080f9164edd9c93891a4153a646
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract The Ciliary Adhesion (CA) complex forms in close association with the basal bodies of cilia during the early stages of ciliogenesis and is responsible for mediating complex interactions with the actin networks of multiciliated cells (MCCs).
Externí odkaz:
https://doaj.org/article/bad1dc5eae284e41b3c59f0c3a97a6d2
Autor:
Nicolas Vignier, Maria Chatzifrangkeskou, Luca Pinton, Hugo Wioland, Thibaut Marais, Mégane Lemaitre, Caroline Le Dour, Cécile Peccate, Déborah Cardoso, Alain Schmitt, Wei Wu, Maria-Grazia Biferi, Naïra Naouar, Coline Macquart, Maud Beuvin, Valérie Decostre, Gisèle Bonne, Guillaume Romet-Lemonne, Howard J. Worman, Francesco Saverio Tedesco, Antoine Jégou, Antoine Muchir
Publikováno v:
Cell Reports, Vol 36, Iss 8, Pp 109601- (2021)
Summary: Cofilins are important for the regulation of the actin cytoskeleton, sarcomere organization, and force production. The role of cofilin-1, the non-muscle-specific isoform, in muscle function remains unclear. Mutations in LMNA encoding A-type
Externí odkaz:
https://doaj.org/article/c556bebb8808453e8abeba29fd9a8cdb
Autor:
Maria Chatzifrangkeskou, Eric O’Neill
Publikováno v:
Molecular & Cellular Oncology, Vol 6, Iss 5 (2019)
Nuclear actin is exported from the nucleus via the Exportin-6 (XPO6)/RAN GTPase complex. We recently identified that RASSF1A and the hippo pathway kinase Mammalian STE20-like protein kinase 2 (MST2) play a pivotal role in nucleocytoplasmic shuttling
Externí odkaz:
https://doaj.org/article/e77402b2534143ccac9566692f9c3f39
Publikováno v:
American Journal of Physiology-Cell Physiology. 324:C1223-C1235
Dilated cardiomyopathy caused by mutations in LMNA, encoding A-type lamins (i.e., LMNA cardiomyopathy), is characterized by a left ventricle enlargement and ultimately results in poor cardiac contractility associated with conduction defects. Despite
Autor:
Ioanna Antoniades, Andria Koulle, Maria Chatzifrangkeskou, Timothea Konstantinou, Paris Skourides
Motile cilia are organelles lining the surfaces of major organs of the human body and generate directional fluid flow. Ciliary dysfunction has been linked to an emerging class of multisystem disorders, collectively known as motile ciliopathies. Drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8381b38e5df255e8d05e3879383becb6
https://doi.org/10.1101/2022.07.12.499724
https://doi.org/10.1101/2022.07.12.499724
Autor:
Vassilis G. Gorgoulis, Eric O'Neill, Zoi Lygerou, Frances Willenbrock, Maria Chatzifrangkeskou, Stavroula Tsaridou, Georgia Velimezi, Andreas Panagopoulos, Dimitris Karamitros, Dafni-Eleftheria Pefani
DNA lesions occur across the genome and constitute a threat to cell viability; however, damage at specific genomic loci has a disproportionally greater impact on the overall genome stability. The ribosomal RNA gene repeats (rDNA) are emerging fragile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::459f0e6b09fc398b6b8f2e422780621c
https://doi.org/10.1101/2021.11.17.469058
https://doi.org/10.1101/2021.11.17.469058
Autor:
Caroline Le Dour, Maria Chatzifrangkeskou, Coline Macquart, Maria M. Magiera, Cécile Peccate, Charlène Jouve, Laura Virtanen, Tiina Heliö, Katriina Aalto-Setälä, Silvia Crasto, Bruno Cadot, Déborah Cardoso, Nathalie Mougenot, Daniel Adesse, Elisa Di Pasquale, Jean-Sébastien Hulot, Pekka Taimen, Carsten Janke, Antoine Muchir
Publikováno v:
Nature communications. 13(1)
Mutations in the lamin A/C gene (LMNA) cause dilated cardiomyopathy associated with increased activity of ERK1/2 in the heart. We recently showed that ERK1/2 phosphorylates cofilin-1 on threonine 25 (phospho(T25)-cofilin-1) that in turn disassembles
The nuclear lamina is a mesh-like network of intermediate filaments localized mainly at the inner surface of the inner nuclear membrane and is composed of proteins called lamins. Many inherited diseases are linked with mutations in nuclear lamins and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77be83ae191e935e03ae316210ae1d32
https://ora.ox.ac.uk/objects/uuid:b1ebfd00-9022-462e-b99e-3c1bbcbe2183
https://ora.ox.ac.uk/objects/uuid:b1ebfd00-9022-462e-b99e-3c1bbcbe2183
Autor:
Anderson J. Ryan, Cameron Brown, Yanyan Jiang, Maria Chatzifrangkeskou, Iolanda Vendrell, Eric O'Neill, Daniela Pankova, Jon N. Buzzelli
Publikováno v:
The EMBO Journal
Lung cancer remains the leading cause of cancer‐related death due to poor treatment responses and resistance arising from tumour heterogeneity. Here, we show that adverse prognosis associated with epigenetic silencing of the tumour suppressor RASSF