Donepezil: An Important Prototype to the Design of New Drug Candidates for Alzheimer’s Disease

Autor: Mariana M. Riquiel, Matheus de Freitas Silva, Flávia Pereira Dias Viegas, Patricia Mattos da Rosa, Marcella S. Moreira, Marcelo Henrique dos Santos, Marisi G. Soares, Maísa Rosa Castelli, Maria Cecília R. Simões, Claudio Viegas

Publikováno v: Mini-Reviews in Medicinal Chemistry. 14:2-19

Alzheimer's disease (AD) is a progressive and incurable neurodegenerative disorder, with a dramatic socioeconomic impact. The progress of AD is characterized by a severe loss in memory and cognition, leading to behavioral changing, depression and dea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b046003e78bc78121ed35602289cf405
https://doi.org/10.2174/1389557513666131119201353

4-{[4-(Hy­droxy­meth­yl)piperidin-1-yl]meth­yl}phenol

Autor: I. M. R. Landre, Marcella S. Moreira, Antonio C. Doriguetto, Claudio Viegas, Maria Cecília R. Simões

Publikováno v: Acta Crystallographica Section E: Structure Reports
Acta Crystallographica Section E, Vol 68, Iss 7, Pp o2275-o2276 (2012)

In the title compound, C13H19NO2, the piperidine ring has a chair conformation with the exocyclic N—C bond in an equatorial position. In the crystal, molecules are linked head-to-tail by phenol O—H...O hydrogen bonds to hydroxymethylene O-atom ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9d503e8c4c8b3af921a230f5c4b7117
http://europepmc.org/articles/PMC3394056