Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Maria Caterina Mione"'
Autor:
Lucia Longhitano, Nunzio Vicario, Daniele Tibullo, Cesarina Giallongo, Giuseppe Broggi, Rosario Caltabiano, Giuseppe Maria Vincenzo Barbagallo, Roberto Altieri, Marta Baghini, Michelino Di Rosa, Rosalba Parenti, Antonio Giordano, Maria Caterina Mione, Giovanni Li Volti
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The tumor microenvironment (TME) plays a pivotal role in establishing malignancy, and it is associated with high glycolytic metabolism and lactate release through monocarboxylate transporters (MCTs). Several lines of evidence suggest that lactate als
Externí odkaz:
https://doaj.org/article/fb35dcd54d6f419bb4ae1b4a42baf9f9
Autor:
Karla Misselbeck, Silvia Parolo, Francesca Lorenzini, Valeria Savoca, Lorena Leonardelli, Pranami Bora, Melissa J. Morine, Maria Caterina Mione, Enrico Domenici, Corrado Priami
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Metabolic syndrome is characterized by complex phenotypes that increases the risk of cardiovascular disease and type 2 diabetes. Here the authors’ integrative network analysis suggests BTK inhibitor ibrutinib to be a promising treatment through its
Externí odkaz:
https://doaj.org/article/f96705c65bfd49bc85730e82b064dab7
Autor:
Aurora Irene Idilli, Emilio Cusanelli, Francesca Pagani, Francesco Berardinelli, Manuel Bernabé, María Luisa Cayuela, Pietro Luigi Poliani, Maria Caterina Mione
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
The activation of a telomere maintenance mechanism (TMM) is an essential step in cancer progression to escape replicative senescence and apoptosis. Alternative lengthening of telomeres (ALT) is found in a subset of malignant brain tumors with poor ou
Externí odkaz:
https://doaj.org/article/6bc6d63613bf4f0d8af770922176d738
Autor:
Thomas Dickmeis, Yi Feng, Maria Caterina Mione, Nikolay Ninov, Massimo Santoro, Herman P. Spaink, Philipp Gut
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
In the past years, evidence has emerged that hallmarks of human metabolic disorders can be recapitulated in zebrafish using genetic, pharmacological or dietary interventions. An advantage of modeling metabolic diseases in zebrafish compared to other
Externí odkaz:
https://doaj.org/article/23633791d6ef4a2db7fa7d45ad797fb9
Autor:
Maria Luisa Cayuela, Kathleen B. M. Claes, Miguel Godinho Ferreira, Catarina Martins Henriques, Fredericus van Eeden, Máté Varga, Jeroen Vierstraete, Maria Caterina Mione
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 6 (2019)
Cancer is a disease of the elderly, and old age is its largest risk factor. With age, DNA damage accumulates continuously, increasing the chance of malignant transformation. The zebrafish has emerged as an important vertebrate model to study these pr
Externí odkaz:
https://doaj.org/article/7b328a883d234ebb8a28ac3b5b5abbe0
Autor:
Aurora Irene Idilli, Cecilia Pazzi, Francesca dal Pozzolo, Michela Roccuzzo, Maria Caterina Mione
Publikováno v:
Genes, Vol 11, Iss 12, p 1442 (2020)
Cohesin is a protein complex consisting of four core subunits responsible for sister chromatid cohesion in mitosis and meiosis, and for 3D genome organization and gene expression through the establishment of long distance interactions regulating tran
Externí odkaz:
https://doaj.org/article/b85dfb98e6724175a45e0d1de4250089
Autor:
Aurora Irene Idilli, Francesca Pagani, Emanuela Kerschbamer, Francesco Berardinelli, Manuel Bernabé, María Luisa Cayuela, Silvano Piazza, Pietro Luigi Poliani, Emilio Cusanelli, Maria Caterina Mione
Publikováno v:
Cancers, Vol 12, Iss 4, p 1028 (2020)
Background: The up-regulation of a telomere maintenance mechanism (TMM) is a common feature of cancer cells and a hallmark of cancer. Routine methods for detecting TMMs in tumor samples are still missing, whereas telomerase targeting treatments are b
Externí odkaz:
https://doaj.org/article/ffcf05976b0e465a9c9a2294ded46b08
Publikováno v:
Genes, Vol 8, Iss 9, p 236 (2017)
Over the past 15 years, zebrafish have emerged as a powerful tool for studying human cancers. Transgenic techniques have been employed to model different types of tumors, including leukemia, melanoma, glioblastoma and endocrine tumors. These models p
Externí odkaz:
https://doaj.org/article/ab57d08524544f5cae07c55d88c6ded4
Autor:
Corrado Priami, Melissa J. Morine, Valeria Savoca, Karla Misselbeck, Silvia Parolo, Pranami Bora, Maria Caterina Mione, Francesca Lorenzini, Enrico Domenici, Lorena Leonardelli
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
Metabolic syndrome is a pathological condition characterized by obesity, hyperglycemia, hypertension, elevated levels of triglycerides and low levels of high-density lipoprotein cholesterol that increase cardiovascular disease risk and type 2 diabete
Autor:
Lucia Longhitano, Nunzio Vicario, Stefano Forte, Cesarina Giallongo, Giuseppe Broggi, Rosario Caltabiano, Giuseppe Maria Vincenzo Barbagallo, Roberto Altieri, Giuseppina Raciti, Michelino Di Rosa, Massimo Caruso, Rosalba Parenti, Arcangelo Liso, Federica Busi, Marco Lolicato, Maria Caterina Mione, Giovanni Li Volti, Daniele Tibullo
Publikováno v:
Cancer immunology, immunotherapy : CII. 72(1)
Lactic acidosis has been reported in solid tumor microenvironment (TME) including glioblastoma (GBM). In TME, several signaling molecules, growth factors and metabolites have been identified to induce resistance to chemotherapy and to sustain immune