Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Maria Caterina De Rosa"'
Autor:
Matthew C. Pahl, Claudia A. Doege, Kenyaita M. Hodge, Sheridan H. Littleton, Michelle E. Leonard, Sumei Lu, Rick Rausch, James A. Pippin, Maria Caterina De Rosa, Alisha Basak, Jonathan P. Bradfield, Reza K. Hammond, Keith Boehm, Robert I. Berkowitz, Chiara Lasconi, Chun Su, Alessandra Chesi, Matthew E. Johnson, Andrew D. Wells, Benjamin F. Voight, Rudolph L. Leibel, Diana L. Cousminer, Struan F. A. Grant
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Understanding the genetic regulation of hypothalamic function could yield insights into disease pathogenesis, but its inaccessibility has made this challenging. Here the authors present a high-resolution chromatin atlas of a hypothalamic-like neuron
Externí odkaz:
https://doaj.org/article/87b561b18c73423d8f4af95c3968229a
Autor:
Maria Caterina De Rosa, Hannah J. Glover, George Stratigopoulos, Charles A. LeDuc, Qi Su, Yufeng Shen, Mark W. Sleeman, Wendy K. Chung, Rudolph L. Leibel, Judith Y. Altarejos, Claudia A. Doege
Publikováno v:
JCI Insight, Vol 6, Iss 16 (2021)
Energy balance is controlled by interconnected brain regions in the hypothalamus, brainstem, cortex, and limbic system. Gene expression signatures of these regions can help elucidate the pathophysiology underlying obesity. RNA sequencing was conducte
Externí odkaz:
https://doaj.org/article/ee350ea6a47341e992a1ee06fdf5670e
Autor:
Elizabeth J Millings, Maria Caterina De Rosa, Sarah Fleet, Kazuhisa Watanabe, Richard Rausch, Dieter Egli, Gen Li, Charles A Leduc, Yiying Zhang, Stuart G Fischer, Rudolph L Leibel
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197548 (2018)
We have previously reported that Ildr2 knockdown via adenovirally-delivered shRNA causes hepatic steatosis in mice. In the present study we investigated hepatic biochemical and anatomic phenotypes of Cre-mediated Ildr2 knock-out mice. Liver-specific
Externí odkaz:
https://doaj.org/article/66d806134ca748b497d61b5b6864b91d
Autor:
George Stratigopoulos, Maria Caterina De Rosa, Charles A LeDuc, Rudolph L Leibel, Claudia A Doege
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0198637 (2018)
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein-9 (Cas9) has become the tool of choice for genome editing. Despite the fact that it has evolved as a highly efficient means to edit/replace coding sequence,
Externí odkaz:
https://doaj.org/article/3a00118510ac4a0bb0b82e7385a50247
Autor:
Jonathan P. Bradfield, Benjamin F. Voight, Chun Su, Kenyaita M. Hodge, Claudia A. Doege, Rick Rausch, Robert I. Berkowitz, Struan F.A. Grant, Diana L. Cousminer, Sumei Lu, Michelle E. Leonard, Matthew E. Johnson, Alisha Basak, Maria Caterina De Rosa, Matthew C. Pahl, James A. Pippin, Sheridan H. Littleton, Rudolph L. Leibel, Keith Boehm, Andrew D. Wells, Reza K. Hammond, Chiara Lasconi, Alessandra Chesi
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The hypothalamus regulates metabolic homeostasis by influencing behavior and endocrine systems. Given its role governing key traits, such as body weight and reproductive timing, understanding the genetic regulation of hypothalamic development and fun
Autor:
Linshan Shang, Yiying Zhang, Damian J. Williams, Dieter Egli, Rudolph L. Leibel, Deyou Zheng, Liheng Wang, Lina Sui, Maria Caterina De Rosa, Sunil K Panigrahi, Robin Goland, Hannah J. Glover, Lisa Cole Burnett, George Stratigopoulos, Claudia A. Doege, Sharon L. Wardlaw, Yang Liu, Stephen H. Tsang, Charles A. LeDuc
Publikováno v:
J Clin Invest
Bardet-Biedl syndrome (BBS) is a rare autosomal recessive disorder caused by mutations in genes encoding components of the primary cilium and is characterized by hyperphagic obesity. To investigate the molecular basis of obesity in human BBS, we deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5260dbd8dd2a88ed7d4ad12b4f75a2e5
https://europepmc.org/articles/PMC8262481/
https://europepmc.org/articles/PMC8262481/
Autor:
Vidhu V Thaker, Maria Caterina De Rosa, Struan F.A. Grant, K. Liimatta, Alessandra Chesi, Sinead Christensen, Molly C McDonald, Benjamin Weaver, Hakon Hakonarson, Justin Zhou, Claudia A. Doege, Shana E. McCormack, Joel N. Hirschhorn, Michael Rosenbaum
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 104:2961-2970
CONTEXT: Mutations in melanocortin receptor (MC4R) are the most common cause of monogenic obesity in children of European ancestry, but little is known about their prevalence in children from the minority populations in the United States. OBJECTIVE:
Autor:
Amy Fleischman, Alexander Fisette, Carmelo Quarta, Cristina García-Cáceres, Yanjun Xu, Maria Caterina De Rosa, Richard Rausch, Vidhu V Thaker, Matthias H. Tschöp, Joel N. Hirschhorn, Claudia A. Doege
Publikováno v:
Journal of the Endocrine Society
Introduction: Tbx3 has been shown to play a role in the terminal specification of hypothalamic melanocortin neurons during neonatal development & in maintaining the plasticity of their peptidergic role in adulthood in animal experiments (1). The abse
Autor:
George Stratigopoulos, Ross M. Tanis, Holly L. Aaron, Nicolas F. Berbari, Richard Rausch, Dieter Egli, Manika Purohit, Claudia A. Doege, Kathryn E. Birkenbach, Jerica Tan, Xueting Li, Liheng Wang, Alain J. De Solis, Gabriela J. Martins, Jacob M. Levenson, Rui M. Costa, Jen-Yi Lee, Maria Caterina De Rosa, Yossef Goffer, Rudolph L. Leibel, Jens C. Brüning, Staci E. Engle
Publikováno v:
JCI insight, vol 4, iss 3
Intronic polymorphisms in the α-ketoglutarate-dependent dioxygenase gene (FTO) that are highly associated with increased body weight have been implicated in the transcriptional control of a nearby ciliary gene, retinitis pigmentosa GTPase regulator-
Autor:
Carmelo Quarta, Mathias Treier, Maria Caterina De Rosa, Beata Legutko, Alexandre Fisette, Gert O. Pflugfelder, Tim Gruber, Alexander Reim, Gustav Collden, Cristina García-Cáceres, Matthias Mann, Valentina Klaus, Dhiraj G. Kabra, Anne-Laure Poher, Yu-Ting Tseng, Ilona C. Grunwald Kadow, Rick Rausch, Alberto Cebrian-Serrano, Claudia A. Doege, Tim M. Strom, Michael Wierer, Vidhu V Thaker, Matthias H. Tschöp, Luigi Bellocchio, Lori M. Zeltser, Anne Moon, Stephen C. Woods, Yanjun Xu, Rubén Nogueiras, Ophélia Le Thuc, Elisabeth Graf
Publikováno v:
Nat. Metab. 1, 222-235 (2019)
Nat Metab
Nature Metabolism
Nat Metab
Nature Metabolism
Heterogeneous populations of hypothalamic neurons orchestrate energy balance via the release of specific signatures of neuropeptides. However, how specific intracellular machinery controls peptidergic identities and function of individual hypothalami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5854c513ae1f9fc58f652b965710eacd
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=55677
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=55677