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Akademický článek

Unraveling the Connection: Cholesterol, Calcium Signaling, and Neurodegeneration

Publikováno v: Neuroscience Insights, Vol 19 (2024)

Cholesterol and calcium play crucial roles as integral structural components and functional signaling entities within the central nervous system. Disruption in cholesterol homeostasis has been linked to Alzheimer’s, Parkinson’s, and Huntington’

Externí odkaz: https://doaj.org/article/a2dc2c627bc448d19b6d9cd85ffe5cab

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Akademický článek

NPC1-dependent alterations in KV2.1–CaV1.2 nanodomains drive neuronal death in models of Niemann-Pick Type C disease

Autor: Maria Casas, Karl D. Murray, Keiko Hino, Nicholas C. Vierra, Sergi Simó, James S. Trimmer, Rose E. Dixon, Eamonn J. Dickson

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)

Abstract Lysosomes communicate through cholesterol transfer at endoplasmic reticulum (ER) contact sites. At these sites, the Niemann Pick C1 cholesterol transporter (NPC1) facilitates the removal of cholesterol from lysosomes, which is then transferr

Externí odkaz: https://doaj.org/article/8e457916b01b415d80b45482e83ca4c6

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Akademický článek

α-Synuclein-dependent increases in PIP5K1γ drive inositol signaling to promote neurotoxicity

Autor: Jonathan D. Horvath, Maria Casas, Candice Kutchukian, Sara Creus Sánchez, Melissa R. Pergande, Stephanie M. Cologna, Sergi Simó, Rose E. Dixon, Eamonn J. Dickson

Publikováno v: Cell Reports, Vol 42, Iss 10, Pp 113244- (2023)

Summary: Anomalous aggregation of α-synuclein (α-Syn) is a pathological hallmark of many degenerative synucleinopathies including Lewy body dementia (LBD) and Parkinson’s disease (PD). Despite its strong link to disease, the precise molecular mec

Externí odkaz: https://doaj.org/article/ff98fe59a9e9430e909a2ae22edbc46d

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Akademický článek

Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth

Autor: Marta Palomo-Guerrero, Rut Fadó, Maria Casas, Marta Pérez-Montero, Miguel Baena, Patrick O Helmer, José Luis Domínguez, Aina Roig, Dolors Serra, Heiko Hayen, Harald Stenmark, Camilla Raiborg, Núria Casals

Publikováno v: eLife, Vol 8 (2019)

Anterograde transport of late endosomes or lysosomes (LE/Lys) is crucial for proper axon growth. However, the role of energetic nutrients has been poorly explored. Malonyl-CoA is a precursor of fatty acids, and its intracellular levels highly fluctua

Externí odkaz: https://doaj.org/article/3271027ebcbb4e948ef1a81bd8c4e174

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Akademický článek

Protocol for the Generation of a Transcription Factor Open Reading Frame Collection (TFome)

Autor: John Gray, Brett Burdo, Mary Goetting-Minesky, Bettina Wittler, Matthew Hunt, Tai Li, David Velliquette, Julie Thomas, Tina Agarwal, Kasey Key, Irene Gentzel, Michael Brito, Maria Mejía-Guerra, Layne Connolly, Dalya Qaisi, Wei Li, Maria Casas, Andrea Doseff, Erich Grotewold

Publikováno v: Bio-Protocol, Vol 5, Iss 15 (2015)

The construction of a physical collection of open reading frames (ORFeomes) for genes of any model organism is a useful tool for the exploration of gene function, gene regulation, and protein-protein interaction. Here we describe in detail a protocol

Externí odkaz: https://doaj.org/article/ad0bd748adf9430ba19d27b6a3130374

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