Výsledky vyhledávání - "Maria Carmona Iragui"

Akademický článek

Neural correlates of episodic memory in adults with Down syndrome and Alzheimer’s disease

Publikováno v: Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-10 (2022)

Abstract Background Adults with Down syndrome are at an ultra-high risk of developing early-onset Alzheimer’s disease. Episodic memory deficits are one of the earliest signs of the disease, but their association with regional brain atrophy in the p

Externí odkaz: https://doaj.org/article/bb83f1f0007549a38acaf11efccf2f77

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Akademický článek

Plasma glial fibrillary acidic protein and neurofilament light chain for the diagnostic and prognostic evaluation of frontotemporal dementia

Publikováno v: Translational Neurodegeneration, Vol 10, Iss 1, Pp 1-12 (2021)

Abstract Background Astrocytes play an essential role in neuroinflammation and are involved in the pathogenesis of neurodenegerative diseases. Studies of glial fibrillary acidic protein (GFAP), an astrocytic damage marker, may help advance our unders

Externí odkaz: https://doaj.org/article/6687482bcff54ddc98db373982187b7c

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Akademický článek

VAMP-2 is a surrogate cerebrospinal fluid marker of Alzheimer-related cognitive impairment in adults with Down syndrome

Publikováno v: Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-10 (2021)

Abstract Background There is an urgent need for objective markers of Alzheimer’s disease (AD)-related cognitive impairment in people with Down syndrome (DS) to improve diagnosis, monitor disease progression, and assess response to disease-modifying

Externí odkaz: https://doaj.org/article/847ead8ea91e4a79b59f578b40be03af

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Akademický článek

Cerebrospinal fluid profile of NPTX2 supports role of Alzheimer’s disease-related inhibitory circuit dysfunction in adults with Down syndrome

Autor: Olivia Belbin, Mei-Fang Xiao, Desheng Xu, Maria Carmona-Iragui, Jordi Pegueroles, Bessy Benejam, Laura Videla, Susana Fernández, Isabel Barroeta, Raúl Nuñez-Llaves, Victor Montal, Eduard Vilaplana, Miren Altuna, Jordi Clarimón, Daniel Alcolea, Rafael Blesa, Alberto Lleó, Paul F. Worley, Juan Fortea

Publikováno v: Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-10 (2020)

Abstract Background Alzheimer’s disease (AD) is the major cause of death in adults with Down syndrome (DS). There is an urgent need for objective markers of AD in the DS population to improve early diagnosis and monitor disease progression. NPTX2 h

Externí odkaz: https://doaj.org/article/0c1c43d3ccb644e492a07268b4f71135

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Akademický článek

DYRK1A and Activity-Dependent Neuroprotective Protein Comparative Diagnosis Interest in Cerebrospinal Fluid and Plasma in the Context of Alzheimer-Related Cognitive Impairment in Down Syndrome Patients

Autor: Manon Moreau, Maria Carmona-Iragui, Miren Altuna, Lorraine Dalzon, Isabel Barroeta, Marie Vilaire, Sophie Durand, Juan Fortea, Anne-Sophie Rebillat, Nathalie Janel

Publikováno v: Biomedicines, Vol 10, Iss 6, p 1380 (2022)

Down syndrome (DS) is a complex genetic condition due to an additional copy of human chromosome 21, which results in the deregulation of many genes. In addition to the intellectual disability associated with DS, adults with DS also have an ultrahigh

Externí odkaz: https://doaj.org/article/a1e8ccb6ce1d43aa85966d7f9b2a96f9

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Akademický článek

Medical vulnerability of individuals with Down syndrome to severe COVID-19–data from the Trisomy 21 Research Society and the UK ISARIC4C survey

Publikováno v: EClinicalMedicine, Vol 33, Iss , Pp 100769- (2021)

Background: Health conditions, immune dysfunction, and premature aging associated with trisomy 21 (Down syndrome, DS) may impact the clinical course of COVID-19. Methods: The T21RS COVID-19 Initiative launched an international survey for clinicians o

Externí odkaz: https://doaj.org/article/9c25be214b9744a8ba1cb6dcf20d9d05

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Akademický článek

Diagnosis of prodromal and Alzheimer's disease dementia in adults with Down syndrome using neuropsychological tests

Autor: Bessy Benejam, Laura Videla, Eduard Vilaplana, Isabel Barroeta, Maria Carmona‐Iragui, Miren Altuna, Silvia Valldeneu, Susana Fernandez, Sandra Giménez, Florencia Iulita, Diana Garzón, Alexandre Bejanin, David Bartrés‐Faz, Sebastià Videla, Daniel Alcolea, Rafael Blesa, Alberto Lleó, Juan Fortea

Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)

Abstract Introduction We aimed to define prodromal Alzheimer's disease (AD) and AD dementia using normative neuropsychological data in a large population‐based cohort of adults with Down syndrome (DS). Methods Cross‐sectional study. DS participan

Externí odkaz: https://doaj.org/article/0579f0c49bca4a428c6a9aedf4d7f93f

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Akademický článek

Monoaminergic impairment in Down syndrome with Alzheimer's disease compared to early‐onset Alzheimer's disease

Autor: Alain D. Dekker, Yannick Vermeiren, Maria Carmona‐Iragui, Bessy Benejam, Laura Videla, Ellen Gelpi, Tony Aerts, Debby Van Dam, Susana Fernández, Alberto Lleó, Sebastian Videla, Anne Sieben, Jean‐Jacques Martin, Netherlands Brain Bank, Rafael Blesa, Juan Fortea, Peter P. De Deyn

Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 10, Iss 1, Pp 99-111 (2018)

Abstract Introduction People with Down syndrome (DS) are at high risk for Alzheimer's disease (AD). Defects in monoamine neurotransmitter systems are implicated in DS and AD but have not been comprehensively studied in DS. Methods Noradrenaline, adre

Externí odkaz: https://doaj.org/article/d4ab168ebe3f432eb3c4e7d2baaea7d3

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