Výsledky vyhledávání - "Maria C. Larocca"

Akademický článek

Alpha lipoic acid diminishes migration and invasion in hepatocellular carcinoma cells through an AMPK-p53 axis

Autor: Florencia Hidalgo, Anabela C. Ferretti, Carla Borini Etichetti, Emilia Baffo, Alejandro P. Pariani, Tomás Rivabella Maknis, Javier Bussi, Javier E. Girardini, María C. Larocca, Cristián Favre

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)

Abstract Hepatocellular carcinoma (HCC) associated with viral or metabolic liver diseases is a growing cancer without effective therapy. AMPK is downregulated in HCC and its activation diminishes tumor growth. Alpha lipoic acid (ALA), an indirect AMP

Externí odkaz: https://doaj.org/article/1b8c4ab707244dcaae464ca499d9c340

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Angiotensin II type 2 receptor agonist, compound 21, prevents tubular epithelial cell damage caused by renal ischemia

Autor: Maria C. Larocca, Jorge Molinas, Liliana Alicia Monasterolo, Florencia Hidalgo, Sara Molinas, María Fernanda Fussi, Susana Beatriz Marquez, Alejandro Pariani, Gabriel Marcelo Buono

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

During ischemic acute kidney injury (AKI), loss of cytoskeletal integrity and disruption of intercellular junctions are rapid events in response to ATP depletion. Angiotensin II type 2 receptor (AT2R) is overexpressed in injury situations and its sti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622af5b7a85396a9f810ca6f57db4677
https://doi.org/10.1016/j.bcp.2021.114804

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Corrigendum to 'Identification of a CIP4 PKA phosphorylation site involved in the regulation of cancer cell invasiveness and metastasis' [Canc. Lett. 461 (2019) 65–77]

Autor: Evangelina Almada, Maria C. Larocca, J. Girardini, Alejandro Pariani, M. Menacho-Marquez, Carla Borini-Etichetti, Cristián Favre, James R. Goldenring, M.J. Rico, Facundo M. Tonucci, Florencia Hidalgo

Publikováno v: Cancer Letters. 473:200-201

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eca0c226643bb4b2b0c3d5bb2aa93aa8
https://doi.org/10.1016/j.canlet.2019.12.033

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Metformin and glucose starvation decrease the migratory ability of hepatocellular carcinoma cells: targeting AMPK activation to control migration

Autor: Maria C. Larocca, Anabela Ferretti, Cristián Favre, Facundo M. Tonucci, Alejandro Pariani, Florencia Hidalgo, Evangelina Almada

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports

Hepatocellular carcinoma (HCC) is a highly metastatic cancer with very poor prognosis. AMP activated kinase (AMPK) constitutes a candidate to inhibit HCC progression. First, AMPK is downregulated in HCC. Second, glucose starvation induces apoptosis i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e2894d8d02d5aa1b645e8fd0ae5e44f
http://www.nature.com/articles/s41598-019-39556-w

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Hepatic gene transfer of human aquaporin‐1 improves bile salt secretory failure in rats with estrogen‐induced cholestasis

Autor: Maria C. Larocca, Mauro Danielli, Raul Alberto Marinelli, Julieta Marrone, leandro raúl soria, Guillermo L. Lehmann

Publikováno v: Hepatology. 64:535-548

The adenoviral gene transfer of human aquaporin-1 (hAQP1) water channels to the liver of 17α-ethinylestradiol-induced cholestatic rats improves bile flow, in part by enhancing canalicular hAQP1-mediated osmotic water secretion. To gain insight into

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::811cebda8c0a779e8761bb260c8fb831
https://doi.org/10.1002/hep.28564

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Mechanisms of canalicular transporter endocytosis in the cholestatic rat liver

Autor: Maria C. Larocca, Fernando A. Crocenzi, Enrique J. Sánchez Pozzi, Raúl A. Marinelli, Marcelo G. Roma, Julieta Marrone, Gisel Sabrina Miszczuk, Andrea Carolina Boaglio, Ismael Ricardo Barosso

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Impaired canalicular secretion due to increased endocytosis and intracellular retention of canalicular transporters such as BSEP and MRP2 is a main, common pathomechanism of cholestasis. Nevertheless, the mechanisms governing this process are unknown

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f7fdd91d4ca46b81f1be95909dd87b5
https://www.sciencedirect.com/science/article/pii/S0925443918300164

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Microtubules regulate brush border formation

Autor: Facundo M. Tonucci, Florencia Hidalgo, Anabela Ferretti, Irina Kaverina, Cristián Favre, Rodrigo Vena, Maria C. Larocca, Pamela Cribb, Matthew J. Tyska, Evangelina Almada

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Most epithelial cells contain apical membrane structures associated to bundles of actin filaments, which constitute the brush border. Whereas microtubule participation in the maintenance of the brush border identity has been characterized, their cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d03853463e7822983cec0864c71deb53
Wiley Online Library

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Protein kinase C-dependent inhibition of the lysosomal degradation of endocytosed proteins in rat hepatocytes

Autor: Raúl A. Marinelli, Elena J. Ochoa, Emilio A. Rodríguez Garay, Maria C. Larocca

Publikováno v: Cellular Signalling. 14:641-647

We studied the role of protein kinase C (PKC) in the lysosomal processing of endocytosed proteins in isolated rat hepatocytes. We used [14C]sucrose-labeled horseradish peroxidase ([14C]S-HRP) to simultaneously evaluate endocytosis and lysosomal prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76528b99933b6d78fb1d9a552f504b6d
https://doi.org/10.1016/s0898-6568(02)00003-7

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Taurocholate-induced inhibition of hepatic lysosomal degradation of horseradish peroxidase

Autor: Maria C. Larocca, Emilio A. Rodríguez Garay, Raúl A. Marinelli, José M. Pellegrino

Publikováno v: Biochimica et Biophysica Acta (BBA) - General Subjects. 1428:341-347

Endocytosed proteins in hepatocytes are transported to lysosomes for degradation. Metabolites accumulating in these organelles are released into bile by exocytosis, a process that seems to be regulated by the bile salt taurocholate (TC). In this stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09db6624885b75608b83955861e3cbcf
https://doi.org/10.1016/s0304-4165(99)00077-x

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Taurolithocholate can inhibit the biliary discharge of lysosomes in the rat

Autor: Maria C. Larocca, José M. Pellegrino, Raúl A. Marinelli

Publikováno v: Biochimica et Biophysica Acta (BBA) - General Subjects. 1334:155-160

The natural bile salt taurolithocholate (TLC) impairs the biliary excretion of lipids and proteins, which are known to reach the canaliculus via vesicles. In this study we examined whether these observations could be extended to the exocytic discharg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7dc7f2d16d28803565389ad32ce0207
https://doi.org/10.1016/s0304-4165(96)00087-6

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