Výsledky vyhledávání - "Maria C. Kuppner"

Heat shock proteins, immune competence and vaccination

Autor: Maria C. Kuppner, Elfriede Noessner, Valeria Milani, Rolf-Dieter Issels, M Endres

Publikováno v: DMW - Deutsche Medizinische Wochenschrift. 129:31-35

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d68d26d0d15ed312044582b4489acdd
https://doi.org/10.1055/s-2004-812659

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Tumor-Derived Heat Shock Protein 70 Peptide Complexes Are Cross-Presented by Human Dendritic Cells

Autor: Anna Brandl, Rolf D. Issels, Elisabeth Kremmer, Robert Gastpar, Valeria Milani, Stuart K. Calderwood, Alexzander Asea, Elfriede Noessner, Peter Hutzler, Miriam Roos, Maria C. Kuppner

Publikováno v: Europe PubMed Central
Scopus-Elsevier

Our study demonstrates that tumor-derived heat shock protein (HSP)70 chaperones a tyrosinase peptide and mediates its transfer to human immature dendritic cells (DCs) by receptor-dependent uptake. Human tumor-derived HSP70 peptide complexes (HSP70-PC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4f1e9e7784432000af043a0709a0d9
https://doi.org/10.4049/jimmunol.169.10.5424

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The role of heat shock protein (hsp70) in dendritic cell maturation: Hsp70 induces the maturation of immature dendritic cells but reduces DC differentiation from monocyte precursors

Autor: Elfriede Nössner, Rolf D. Issels, Robert Gastpar, Maria C. Kuppner, Oswin Ochmann, Anabel Scharner, Svetlana Gelwer

Publikováno v: European Journal of Immunology. 31:1602-1609

Members of the heat shock protein (hsp70) family are either constitutively expressed (hsc70) or can be induced by hyperthermic stress (hsp70). Recombinant hsp70 (rhsp70) stimulates cytokine production from monocytes and enhances NK cell proliferation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::164b7fe0fd7206ade15f2cf66701a683
https://doi.org/10.1002/1521-4141(200105)31:5<1602::aid-immu1602>3.0.co

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Differential capacity of chaperone-rich lysates in cross-presenting human endogenous and exogenous melanoma differentiation antigens

Autor: Anna Brandl, Henriette Bendz, Maria C. Kuppner, Valeria Milani, Michael W. Graner, Birgit Sirch, Rolf D. Issels, Sylvia Thompson, Emmanuel Katsanis, Elke Bleifuss, Elfriede Noessner, Ingo Drexler

Publikováno v: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 24(8)

The goal of immune-based tumor therapies is the activation of immune cells reactive against a broad spectrum of tumor-expressed antigens. Vaccines based on chaperone proteins appear promising as these proteins naturally exist as complexes with variou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8de8aace430f9b00c68dde021f116b0
https://pubmed.ncbi.nlm.nih.gov/18608582

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Ifosfamide impairs the allostimulatory capacity of human dendritic cells by intracellular glutathione depletion

Autor: Oksana Heinz, Rolf D. Issels, Maria C. Kuppner, Valeria Milani, Katharina E. Tschöp, Christoph von Hesler, Anabel Scharner

Publikováno v: Blood. 102(10)

Ifosfamide, a clinically potent chemotherapeutic agent, causes the depletion of intracellular glutathione (GSH) levels in various cell types. GSH is the major intracellular reductant against oxidative stress. 4-Hydroxyifosfamide (4-OH-IF), the activa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e2ef7ed10256b72275eaac66cb9e5e7
https://pubmed.ncbi.nlm.nih.gov/12855564

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Heat shock protein 70: role in antigen presentation and immune stimulation

Autor: S Ghose, Maria C. Kuppner, Valeria Milani, R Gastpar, B Ahrens, Anabel Scharner, Elfriede Noessner, Rolf-Dieter Issels

Publikováno v: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 18(6)

Heat shock proteins (HSP) when released into the extracellular milieu can act simultaneously as a source of antigen due to their ability to chaperone peptides and as a maturation signal for dendritic cells, thereby inducing DCs to cross-present antig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78261d7e83cf5db92f733c7addb1a007
https://pubmed.ncbi.nlm.nih.gov/12537755

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Heat shock proteins and dendritic cells: effects on maturation and antigen presentation

Autor: Valeria Milani, Maria C. Kuppner, Rolf-Dieter Issels, Elfriede Noessner, Robert Gastpar, M. Roos

Publikováno v: European Journal of Cancer. 37:S31

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5648f0a3c12192e7e2033a535595c360
https://doi.org/10.1016/s0959-8049(01)80389-0

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Transforming growth factor-beta 2 down-regulates HLA-DR antigen expression on human malignant glioma cells

Autor: Nicolas de Tribolet, Maria C. Kuppner, Patrick L.F. Zuber

Publikováno v: European journal of immunology. 18(10)

Transforming growth factor-beta (TGF-beta) is known to have a potent inhibitory influence on several immune functions. It has recently been demonstrated that TGF-beta 2 is identical to the glioblastoma-derived T cell suppressor factor (G-TsF). In the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b86fedaa95e2547b342424db2a4849cf
https://pubmed.ncbi.nlm.nih.gov/3142781

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