Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Maria C. Kjellsson"'
Autor:
Gustaf J. Wellhagen, Ashraf Yassen, Dirk Garmann, Astrid Bröker, Alexander Solms, Yang Zhang, Maria C. Kjellsson, Mats O. Karlsson
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 5, Pp 812-822 (2024)
Abstract Item response theory (IRT) models are usually the best way to analyze composite or rating scale data. Standard methods to evaluate covariate or treatment effects in IRT models do not allow to identify item‐specific effects. Finding subgrou
Externí odkaz:
https://doaj.org/article/0139e12916414106b4d7f91451e70005
Autor:
Gustaf J. Wellhagen, Mats O. Karlsson, Maria C. Kjellsson, Dirk Garmann, Astrid Bröker, Yang Zhang, Mika Nokela, Gerrit Weimann, Ashraf Yassen
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 5, Pp 880-890 (2024)
Abstract Obstructive sleep apnea (OSA) is a sleep disorder which is linked to many health risks. The gold standard to evaluate OSA in clinical trials is the Apnea‐Hypopnea Index (AHI). However, it is time‐consuming, costly, and disregards aspects
Externí odkaz:
https://doaj.org/article/993b6e91571c4c6f8e3e4f8438d40464
Autor:
Jennifer Leohr, Maria C. Kjellsson
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 10, Pp 1529-1540 (2023)
Abstract The TIGG model is the first model to integrate glucose and insulin regulation, incretin effect, and triglyceride (TG) response in the lipoprotein subclasses of chylomicrons and VLDL‐V6. This model described the response following a high‐
Externí odkaz:
https://doaj.org/article/a840e8429e754b49abbd787a0d074e29
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 11, Pp 1443-1457 (2022)
Abstract Glycated hemoglobin (HbA1c) is the main biomarker of diabetes drug development. However, because of its delayed turnover, trial duration is rarely shorter than 12 weeks, and being able to predict long‐term HbA1c with precision using data f
Externí odkaz:
https://doaj.org/article/bdf2b96894ba47879840b71afe00a478
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 7, Iss 7, Pp 432-441 (2018)
In antidiabetic drug development, phase I studies usually involve short‐term glucose provocations. Multiple designs are available for these provocations (e.g., meal tolerance tests (MTTs) and graded glucose infusions (GGIs)). With a highly nonlinea
Externí odkaz:
https://doaj.org/article/7ad14f1381404b68b9cadf9c86aa3050
Autor:
Orwa, Albitar, Siti Maisharah Sheikh, Ghadzi, Sabariah Noor, Harun, Siti Nor Aizah, Ahmad, Maria C, Kjellsson
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics. 50:21-31
Clozapine has superior efficacy to other antipsychotics yet is underutilized due to its adverse effects, such as neutropenia, weight gain, and tachycardia. The current investigation aimed to introduce a pharmacometric approach to simultaneously model
Autor:
Sabiha R. Mim, Haneen Hussein, Samira Vidadi, Rory Leisegang, Sumanth Karamchand, Virendra Rambiritch, Mark F. Cotton, Poobalan Naidoo, Maria C. Kjellsson
Publikováno v:
Basic & Clinical Pharmacology & Toxicology.
Autor:
Jennifer, Leohr, Maria C, Kjellsson
Publikováno v:
Clinical Pharmacology & Therapeutics. 112:112-124
The integrated glucose-insulin model is a semimechanistic model describing glucose and insulin after a glucose challenge. Similarly, a semiphysiologic model of the postprandial triglyceride (TG) response in chylomicrons and VLDL-V6 was recently publi
Publikováno v:
Endocrine Connections. 12
This study aimed to characterize how the dysregulation of counter-regulatory hormones can contribute to insulin resistance and potentially to diabetes. Therefore, we investigated the association between insulin sensitivity and the glucose- and insuli
Publikováno v:
The Journal of Clinical Pharmacology. 61:116-124
The integrated minimal model allows assessment of clinical diagnosis indices, for example, insulin sensitivity (SI ) and glucose effectiveness (SG ), from data of the insulin-modified intravenous glucose tolerance test (IVGTT), which is laborious wit